Anthocyanins from purple sweet potato attenuate dimethylnitrosamine-induced liver injury in rats by inducing Nrf2-mediated antioxidant enzymes and reducing COX-2 and iNOS expression

Nadroparin Sodium Activates Nrf2/HO-1 Pathway in Acetic Acid-Induced Colitis in Rats

“…COX-2 is also regulated by redox-sensitive transcription factors, which are activated with presence of oxidative stress [43] and production of COX-2 is upregulated by redox-sensitive transcription factors at inflammation sites [24]. It has been demonstrated that downregulation of COX-2 eventuates in reducing intestinal inflammation [27][28][29] and also leads to amelioration of the colitis [9,30] In the present study, expression of COX-2 in colon of the AA rats was found significantly increased and nadroparin significantly prevented and decreased the expression of COX-2 induced by AA injury in parallel to other proteins analyzed in the present work.…”

“…As HO-1 defensive system, cyclooxygenase-2 (COX-2) production has also been upregulated by redox-sensitive transcription factors at the sites of inflammation [24]. It has been demonstrated that downregulation of COX-2 eventuates in reducing intestinal inflammation [25][26][27] and also leading to amelioration of the colitis [28,29]. In the present study, we aimed to evaluate the effects of nadroparin calcium, a LMWH, treatment on HO-1 expression, and redox-sensitive transcription factors levels (AP-1, NF-κB, and Nrf2), COX-2, TNF-alpha, and IL-6 in acetic acid (AA)-induced colitis in rats.…”

Saeng-Kankunbi-Tang (生肝健脾汤) protects liver against oxidative damage through activation of ERK/Nrf2 pathway

“…(26) It has been shown that mitochondrial dysfunction interrupts intracellular oxidative phosphorylation and increases ROS production. (27) In the present study, tBHP caused hepatocyte death due to the loss of MMP and ROS production. However, pretreatment with SKT signifi cantly inhibited tBHP-induced hepatocyte death via alterations in MMP and ROS production, showing that SKT has anti-oxidant effects in vitro.…”

Cyanidin does not affect sulforaphane-mediated Nrf2 induction in cultured human keratinocytes

“…For transfection with siRNA, 0·2 £ 10 6 HaCaT cells were seeded in twenty-four-well plates and pre-cultured for 24 h. Subsequently, the cells were transfected with 7·7 nmol/l siGENOME SMARTpool for Nrf2, GAPDH and non-targeting siRNA using DharmaFECT 1 (Fisher Scientific, Schwerte, Germany), following the manufacturer's instructions, for 42 h. Transfected and untransfected cells were either treated with the vehicle or SFN (10 mmol/l) for 6 h. Subsequently, RNA was isolated as described above.…”