Anthracimycin, a Potent Anthrax Antibiotic from a Marine‐Derived Actinomycete

Due to the worldwide prevalence of multidrug-resistant pathogens and high incidence of diseases such as cancer, there is an urgent need for the discovery and development of new drugs. Nearly half of the FDA-approved drugs are derived from natural products that are produced by living organisms, mainly bacteria, fungi, and plants. Commercial development is often limited by the low yield of the desired compounds expressed by the native producers. In addition, recent advances in whole genome sequencing and bioinformatics have revealed an abundance of cryptic biosynthetic gene clusters within microbial genomes. Genetic manipulation of clusters in the native host is commonly used to awaken poorly expressed or silent gene clusters, however, the lack of feasible genetic manipulation systems in many strains often hinders our ability to engineer the native producers. The transfer of gene clusters into heterologous hosts for expression of partial or entire biosynthetic pathways is an approach that can be used to overcome this limitation. Heterologous expression also facilitates the chimeric fusion of different biosynthetic pathways, leading to the generation of “unnatural” natural products. The genus Streptomyces is especially known to be a prolific source of drugs/antibiotics, its members are often used as heterologous expression hosts. In this review, we summarize recent applications of Streptomyces species, S. coelicolor, S. lividans, S. albus, S. venezuelae and S. avermitilis, as heterologous expression systems.

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“…CNH365 and S. sp. T676 (Jang et al, 2013; Alt and Wilkinson, 2015). It exhibits antibacterial activity (≤0.06 μg/mL) against MRSA and VRE.…”

Section: Streptomyces Coelicolor As a Heterologous Hostmentioning

confidence: 99%

Streptomycetes: Surrogate hosts for the genetic manipulation of biosynthetic gene clusters and production of natural products

Nepal

Wang

2019

Biotechnology Advances

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“…(2013) lists 23 antibacterial compounds in preclinical pharmacological research. An interesting example is Anthracimycin, a polyketide antibiotic discovered in 2013, derived from marine actinobacteria that has shown significant activity against Bacillus anthracis , the bacteria that causes anthrax (Jang et al ., 2013).…”

Section: New Drugs In Developmentmentioning

confidence: 99%

The marine biodiscovery pipeline and ocean medicines of tomorrow

et al. 2016

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Marine organisms possess the capacity to produce a variety of unique and biologically potent natural products for treating human diseases, many of which are currently commercially available or are in advanced clinical trials. Here we provide a short review on progress in the field and discuss a case study of an EU-funded project, PharmaSea, which aims to discover novel products for the treatment of infections, inflammation and neurodegenerative diseases. Research in this sector is opening new doors for harnessing the potential of marine natural products with pharmaceutical properties.

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“…Bacterial metabolites are probably the most promising source for novel antibacterial compounds since most of the natural product-derived antibacterial drugs in the pipeline are from terrestrial actinomycetes [18]. Anthracetin [19], isolated from Streptomyces species is a potential antibiotic against Bacillus anthracis and methicillin-resistant Staphylococcus aureus (MRSA). Another potential antiobiotic against MRSA and vancomycin-resistant enterococci is thiazolyl cyclic-peptide PM181104, isolated from sponge-associated actinobacterium strain of the genus Kocuria [20].…”

Section: Marine Bacteriamentioning

confidence: 99%

Exploring Marine Resources for Bioactive Compounds

et al. 2014

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Biodiversity in the seas is only partly explored, although marine organisms are excellent sources for many industrial products. Through close co-operation between industrial and academic partners, it is possible to successfully collect, isolate and classify marine organisms, such as bacteria, fungi, micro- and macroalgae, cyanobacteria, and marine invertebrates from the oceans and seas globally. Extracts and purified compounds of these organisms can be studied for several therapeutically and industrially significant biological activities, including anticancer, anti-inflammatory, antiviral, antibacterial, and anticoagulant activities by applying a wide variety of screening tools, as well as for ion channel/receptor modulation and plant growth regulation. Chromatographic isolation of bioactive compounds will be followed by structural determination. Sustainable cultivation methods for promising organisms and biotechnological processes for selected compounds can be developed, as well as biosensors for monitoring the target compounds. The (semi)synthetic modification of marine-based bioactive compounds produces their new derivatives, structural analogs and mimetics that could serve as hit or lead compounds and be used to expand compound libraries based on marine natural products. The research innovations can be targeted for industrial product development in order to improve the growth and productivity of marine biotechnology. Marine research aims at a better understanding of environmentally conscious sourcing of marine biotechnology products and increased public awareness of marine biodiversity. Marine research is expected to offer novel marine-based lead compounds for industries and strengthen their product portfolios related to pharmaceutical, nutraceutical, cosmetic, agrochemical, food processing, material and biosensor applications.

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Anthracimycin, a Potent Anthrax Antibiotic from a Marine‐Derived Actinomycete

Cited by 18 publications

References 5 publications

Streptomycetes: Surrogate hosts for the genetic manipulation of biosynthetic gene clusters and production of natural products

Streptomycetes: Surrogate hosts for the genetic manipulation of biosynthetic gene clusters and production of natural products

The marine biodiscovery pipeline and ocean medicines of tomorrow

Exploring Marine Resources for Bioactive Compounds

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