Anthraquinone–steroids, evanthrasterol A and B, and a meroterpenoid, emericellic acid, from endophytic fungus, Emericella variecolor

Liangsakul, Jatupol; Srisurichan, Suphongphan; Pornpakakul, Surachai

doi:10.1016/j.steroids.2015.12.012

Cited by 17 publications

(9 citation statements)

References 25 publications

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“…The occurrence of prenylxanthone derivatives from Emericella sp. XL029 is in agreement with the previous ndings, [8][9][10][11][12][13][14] indicating that the isolation of these compounds might be a useful chemotaxonomic marker of the Emericella genus. The results of preliminary anti-agricultural pathogenic fungal and antibacterial assays suggested that these isolated prenylxanthone derivatives showed moderate activity.…”

Section: Discussionsupporting

confidence: 90%

“…[6][7][8][9][10][11][12][13][14] Furthermore, fungi of the Emericella species are the sexual states of Aspergillus species, the perfect states of Aspergillus, has been the source of various classes of bioactive compounds. 8,23,24 During our studies in searching for novel bioactive compounds from plant endophytic fungi, we have isolated the interesting pigment-producing fungal strain (XL029) associated with the leaves of Panax notoginseng, belonging to the genus Emericella. The present study was undertaken to search for novel pigments from the solid-substrate fermentation culture of Emericella sp.…”

Section: Introductionmentioning

confidence: 99%

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New prenylxanthones, polyketide hemiterpenoid pigments from the endophytic fungus Emericella sp. XL029 and their anti-agricultural pathogenic fungal and antibacterial activities

Fang

Liu

et al. 2017

RSC Adv.

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Section: Discussionsupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

New prenylxanthones, polyketide hemiterpenoid pigments from the endophytic fungus Emericella sp. XL029 and their anti-agricultural pathogenic fungal and antibacterial activities

Fang

Liu

et al. 2017

RSC Adv.

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“…Prenylxanthones are heterocyclic metabolites with a core 9 H -xanthen-9-one (dibenzo-γ-pyrone) ring system and functionalized with prenyl groups. , They are mainly discovered from a restricted number of higher plants and fungi, in particular the genera Emericella / Aspergillus . − Prenylxanthones are further subdivided into non-, mono-, di-, tri-, tetra-, penta-, and hexa-oxygenated substances, depending upon the degree of oxygenation of the xanthone core, among which the mono-oxygenated prenylxanthones are relatively rare. ,− With high structural diversity, prenylated xanthones have exhibited various bioactivities, including antibacterial, antifungal, cytotoxicity, antihypertensive, hypoglycemic, and hypolipidemic. , …”

Section: Results and Discussionmentioning

confidence: 99%

Staprexanthones, Xanthone-Type Stimulators of Pancreatic β-Cell Proliferation from a Mangrove Endophytic Fungus

Gan

Lin

et al. 2020

J. Nat. Prod.

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This project was focused on the discovery of novel compounds that promote endogenous β-cell regeneration. Screening of extracts identified the fungus Stachybotrys chartarum as a promising candidate. After fermentation and extraction of S. chartarum, we isolated five new prenylated xanthones, namely, staprexanthones A–E (1–5), with staprexanthone A (1) being the first natural xanthone bearing a rare 4,5-dimethyl-1,3-dioxolane moiety. Compounds 1, 2, and 5 significantly increased β-cell numbers in vivo in a zebrafish model. Further analysis revealed that 2 and 5 promoted β-cell mass expansion by increasing proliferation of existing β-cells though promotion of cell-cycle progression at the G1/S transition. These findings indicate that prenylated xanthones are potential new drug leads for antidiabetes therapy by stimulating β-cell regeneration.

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“…Compounds 90 and 91 were evaluated for their in vitro cytotoxicity against five human tumor cell lines. They showed no cytotoxic effects at 10 µg/mL) [65].…”

Section: Bicoumarinsmentioning

confidence: 92%

Nidulantes of Aspergillus (Formerly Emericella): A Treasure Trove of Chemical Diversity and Biological Activities

et al. 2020

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The genus Emericella (Ascomycota) includes more than thirty species with worldwide distribution across many ecosystems. It is considered a rich source of diverse metabolites. The published classes of natural compounds that are discussed here are organized according to the following biosynthetic pathways: polyketides (azaphilones, cyclopentenone pigments, dicyanides, furan derivatives, phenolic ethers, and xanthones and anthraquinones); shikimate derivatives (bicoumarins); mevalonate derivatives (meroterpenes, sesquiterpenes, sesterterpenes and steroids) and amino acids derivatives (alkaloids (indole-derivatives, isoindolones, and piperazine) and peptides (depsipeptides)). These metabolites produce the wide array of biological effects associated with Emericella, including antioxidant, antiproliferative, antimalarial, antiviral, antibacterial, antioxidant, antihypertensive, anti-inflammatory, antifungal and kinase inhibitors. Careful and extensive study of the diversity and distribution of metabolites produced by the genus Emericella (either marine or terrestrial) revealed that, no matter the source of the fungus, the composition of the culture medium effectively controls the metabolites produced. The topic of this review is the diversity of metabolites that have been identified from Emericella, along with the contextual information on either their biological or geographic sources. This review presents 236 natural compounds, which were reported from marine and terrestrial Emericella. Amongst the reported compounds, only 70.2% were biologically assayed for their effects, including antimicrobial or cytotoxicity. This implies the need for substantial investigation of alternative activities. This review includes a full discussion of compound structures and disease management, based on materials published from 1982 through December 2019.

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Anthraquinone–steroids, evanthrasterol A and B, and a meroterpenoid, emericellic acid, from endophytic fungus, Emericella variecolor

Cited by 17 publications

References 25 publications

New prenylxanthones, polyketide hemiterpenoid pigments from the endophytic fungus Emericella sp. XL029 and their anti-agricultural pathogenic fungal and antibacterial activities

New prenylxanthones, polyketide hemiterpenoid pigments from the endophytic fungus Emericella sp. XL029 and their anti-agricultural pathogenic fungal and antibacterial activities

Staprexanthones, Xanthone-Type Stimulators of Pancreatic β-Cell Proliferation from a Mangrove Endophytic Fungus

Nidulantes of Aspergillus (Formerly Emericella): A Treasure Trove of Chemical Diversity and Biological Activities

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