Anthraquinones and flavanols isolated from the vegetable herb Rumex abyssinicus inhibit motility of Phytophthora capsici zoospores

Tala, Michel Feussi; Ansary, Most. Waheda Rahman; Talontsi, Ferdinand Mouafo; Kowa, Théodora Kopa; Islam, Tofazzal; Tane, Pierre

doi:10.1016/j.sajb.2017.11.015

Cited by 14 publications

(13 citation statements)

References 16 publications

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“…49 For example, the (-)epicatechin, a flavonol 50 has been demonstrated to possess hepatoprotective activity. Also, previous studies reported different bioactive anthraquinones in R. abyssinicus like chrysophanic acid, chrysophanol, emodin, and physcion; 29,39,51 of which chrysophanol, 52 emodin, 53,54 and physcion 55 did show the ability to scavenge freeradicals implying that may serve as natural antioxidant compounds. In line with this notion, emodin, chrysophanol, and physcion were reported to have a potential liverprotecting activity 55 which could be due to their antioxidant activity.…”

Section: Discussionmentioning

confidence: 94%

“…47 In the present study, preliminary phytochemical screening of R. abyssinicus extract showed the possible presence of anthraquinones, alkaloids, saponins, phenols, flavonoids, tannins, and terpenoids which were also consistent with previously reported studies. 28,39,48 Especially, flavonoids possess an antioxidant property, which may be useful in the treatment of liver disease. 49 For example, the (-)epicatechin, a flavonol 50 has been demonstrated to possess hepatoprotective activity.…”

Section: Discussionmentioning

confidence: 99%

“…The preliminary phytochemical screening of R. abyssinicus crude extracts revealed the possible presence of alkaloids, anthraquinones, phenols, flavonoids, saponins, tannins, and terpenoids. Moreover, previous phytochemical studies on R. abyssinicus showed the isolation of methyl gallate (a phenolic acid), 39…”

Section: Preliminary Phytochemical Screeningmentioning

confidence: 99%

“…anthraquinones (chrysophanol, emodin, emodin-8-O-β-D-glucopyranoside, helminthosporin, physcion, and physcion-8-O-β-D-glucopyranoside), 39,40 flavanols (epicatechin, epicatechin-3-O-gallate, and epicatechin-3-O-(4′′methyl) gallate),39 betulone (a triterpenoid), and oleic acid (a fatty acid) from this plant 29. …”

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confidence: 99%

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In vivo Hepatoprotective and in vitro Radical Scavenging Activities of Extracts of Rumex abyssinicus Jacq. Rhizome

Adamu¹,

Emiru²,

Sintayehu³

et al. 2020

JEP

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Background: Liver diseases contribute a prominent global burden of mortality and morbidity. The current therapies of liver diseases have numerous limitations including severe adverse effects. This denotes that new more effective, safer, and cheaper drugs are required and medicinal plants used in traditional medicines often offer ideal opportunities. Accordingly, the present study aimed to evaluate the in vivo hepatoprotective and in vitro radical scavenging activities of dried rhizome extracts of Rumex abyssinicus (R. abyssinicus), which is traditionally claimed to provide hepatoprotection. Materials and Methods: Hepatoprotective activity of extracts was evaluated using carbon tetrachloride (CCl 4)-induced liver injury in mice. Pre-and post-treatment models were employed to test the effect of the extracts and silymarin (standard drug). Serum biochemical markers and liver histopathology were used as parameters to evaluate hepatoprotective activities whereas in vitro radical scavenging activity was tested by 2, 2-diphenyl-2-picrylhydrazyl hydrate (DPPH) assay. Results and Conclusion: Oral administration of CCl 4 (1 ml/kg) significantly (P<0.001) raised the serum levels of liver enzyme markers compared to the normal control group. Pretreatment with 125, 250, and 500 mg/kg of R. abyssinicus extract reduced the serum level of CCl 4-induced rise in liver enzyme markers with the highest reduction observed at a dose of 500 mg/kg. Likewise, in the post-treatment model, the crude extract and butanol fraction at dose 500 mg/kg reduced levels of liver enzymes. Histopathological examinations revealed lesser liver damage of extract-treated mice compared to the toxic (CCl 4-treated) controls. The in vitro radical scavenging activity of the different extracts showed concentration-dependent radical scavenging activity. Thus, the results of this study may justify the traditional use of the plant as a hepatoprotective agent. Conclusion: Results of serum biochemical markers and histopathological examinations of CCl 4-induced mice models, in the present study, show the hepatoprotective potential of extracts from the rhizome of R. abyssinicus.

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Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 99%

Section: Preliminary Phytochemical Screeningmentioning

confidence: 99%

mentioning

confidence: 99%

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In vivo Hepatoprotective and in vitro Radical Scavenging Activities of Extracts of Rumex abyssinicus Jacq. Rhizome

Adamu¹,

Emiru²,

Sintayehu³

et al. 2020

JEP

View full text Add to dashboard Cite

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“…Anthraquinones are also increasingly being explored as privileged scaffolds for pharmaceutical development due to their antimicrobial, anti-cancer and anti-thrombotic activities [ 51 , 52 , 53 ]. Various anthraquinones produced by plants have also been shown to have anti- Phytophthora activities [ 54 , 55 , 56 , 57 ]. However, this study is the first to report the anti- Phytophthora activities of 10 and 13 .…”

Section: Resultsmentioning

confidence: 99%

Screening a Natural Product-Inspired Library for Anti-Phytophthora Activities

et al. 2021

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Phytophthora is a genus of microorganisms that cause devastating dieback and root-rot diseases in thousands of plant hosts worldwide. The economic impact of Phytophthora diseases on crops and native ecosystems is estimated to be billions of dollars per annum. These invasive pathogens are extremely difficult to control using existing chemical means, and the effectiveness of the few treatments available is being jeopardized by increasing rates of resistance. There is an urgent need to identify new chemical treatments that are effective against Phytophthora diseases. Natural products have long been regarded as “Nature’s medicine chest”, providing invaluable leads for developing front-line drugs and agrochemical agents. Here, we have screened a natural product-inspired library of 328 chemicals against two key Phytophthora species: Phytophthora cinnamomi and Phytophthora agathidicida. The library was initially screened for inhibition of zoospore germination. From these screens, we identified twenty-one hits that inhibited germination of one or both species. These hits were further tested in mycelial growth inhibition studies to determine their half-maximal inhibitory concentrations (IC50s). Four compounds had IC50 values of approximately 10 µM or less, and our best hit had IC50s of approximately 3 µM against both Phytophthora species tested. Overall, these hits may serve as promising leads for the development of new anti-Phytophthora agrochemicals

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Plant anthraquinones: Classification, distribution, biosynthesis, and regulation

Wang

Jia

Hua

et al. 2023

Journal Cellular Physiology

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Anthraquinones are polycyclic compounds with an unsaturated diketone structure (quinoid moiety). As important secondary metabolites of plants, anthraquinones play an important role in the response of many biological processes and environmental factors. Anthraquinones are common in the human diet and have a variety of biological activities including anticancer, antibacterial, and antioxidant activities that reduce disease risk. The biological activity of anthraquinones depends on the substitution pattern of their hydroxyl groups on the anthraquinone ring structure. However, there is still a lack of systematic summary on the distribution, classification, and biosynthesis of plant anthraquinones. Therefore, this paper systematically reviews the research progress of the distribution, classification, biosynthesis, and regulation of plant anthraquinones. Additionally, we discuss future opportunities in anthraquinone research, including biotechnology, therapeutic products, and dietary anthraquinones.

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Anthraquinones and flavanols isolated from the vegetable herb Rumex abyssinicus inhibit motility of Phytophthora capsici zoospores

Cited by 14 publications

References 16 publications

<p>In vivo Hepatoprotective and in vitro Radical Scavenging Activities of Extracts of <em>Rumex abyssinicus</em> Jacq. Rhizome</p>

<p>In vivo Hepatoprotective and in vitro Radical Scavenging Activities of Extracts of <em>Rumex abyssinicus</em> Jacq. Rhizome</p>

Screening a Natural Product-Inspired Library for Anti-Phytophthora Activities

Plant anthraquinones: Classification, distribution, biosynthesis, and regulation

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