Anti-breast cancer potential of daidzein in rodents

Li, Xiaoping; Suzuki, N.; Laxmi, Y. R. Santosh; Okamoto, Yoshinori; Shibutani, Shinya

doi:10.1016/j.lfs.2012.08.022

Cited by 65 publications

(26 citation statements)

References 25 publications

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“…Similar activity was detected both for prostate and colon cancer, this last one being one of the most common cancers in the world, with poor response too chemotherapeutic agents [220,221]. Mammary human xenografts have also been sensitive do daidzein,with tumor inhibition and apoptosis described [222]. The preventive capacity of this compound was assessed by Constatinou et al [223] by joining it with tamoxifen and administrating it to mice with induced mammary tumors.…”

Section: Isoflavonesmentioning

confidence: 79%

The Role of Phenolic Compounds in the Fight against Cancer – A Review

Carocho¹,

Ferreira

2013

ACAMC

237

144

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Abstract:Cancer is a worldwide scourge; it's the leading cause of death in developed countries and is increasing in developing countries. Mankind has been trying with effort to find better and cheaper treatments with fewer side effects, to reduce the incidence of the disease and its consequent mortality. For many years, phenolic compounds have been intensely studied for their antitumor, proapoptotic and antiangiogenic effects. In recent years, the usage of these compounds has increased considerably.This manuscript intends to structurally characterize the different phenolic compounds (flavonoids, hydroxycinnamates, hydroxybenzoates, coumarins, xanthones, chalcones, stilbenes, lignins and lignans) and their metabolic pathways as well as review the most important results regarding these compounds and their derivatives in cancer treatment and prevention both in tumor cell lines in vitro, in murine models in vivo and finally some results regarding human trials.

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Section: Isoflavonesmentioning

confidence: 79%

The Role of Phenolic Compounds in the Fight against Cancer – A Review

Carocho¹,

Ferreira

2013

ACAMC

237

144

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“…Genistein, a potent estrogenic isoflavone, has been reported to reduce postmenopausal symptoms in women (Taylor et al, 2009). In addition, daidzein and its active metabolite equol have an ability to suppress the proliferation of human breast cancer xenografts implanted in athymic nude mice (Liu et al, 2012). These reports suggest that phytoestrogens can be used for treatment of postmenopausal symptoms accompanied by cancer chemoprevention.…”

Section: Introductionmentioning

confidence: 97%

Oral administration of Brazilian propolis exerts estrogenic effect in ovariectomized rats

et al. 2015

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-Propolis, a natural product derived from plants by honeybees, is a mixture of several hundred chemicals, including flavonoids, coumaric acids, and caffeic acids, some of which show estrogen-like activity. In this study, the estrogenic activity of crude ethanolic extract of Brazilian propolis was determined using several in vitro and in vivo assays. Propolis was found to bind to human estrogen receptors (ERs). Furthermore, propolis induced the expression of estrogen-responsive genes in ERpositive MCF-7 and Ishikawa cells. These in vitro assays suggest that propolis exerts estrogenic activity; therefore, in vivo experiments were conducted using ovariectomized rats. Oral administration of propolis (55 or 550 mg/kg/day for 3 days) significantly increased uterine wet weight and luminal epithelium thickness in comparison with the corresponding values in the corn oil-treated control group. Moreover, propolis induced ductal cell proliferation in the mammary glands. These effects were completely inhibited by full ER antagonist ICI 182,780, confirming that the effects of propolis are mediated by the ER. Our data show that oral intake of propolis induces estrogenic activity in ER-expressing organs in vivo and suggest that Brazilian propolis is a useful dietary source of phytoestrogens and a promising treatment for postmenopausal symptoms.

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“…Several animal studies have shown a reduction of tumour growth, e.g. for daidzein [18]. However, some results are controversial [19].…”

Section: Discussionmentioning

confidence: 99%

Secondary Metabolites in Flax Root Extracts at Various Stages of Maturity and Effects on Proliferation and Cytotoxicity in Oestrogen-Receptor-Positive Breast Cancer Cells

Szewczyk¹,

Strater²,

Schlichting³

et al. 2014

ABC

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Flax contains large amounts of hormone-like compounds, especially lignans. These so-called phytoestrogens are thought to inhibit the cell growth of hormone-sensitive cancers. Hence, we analysed the influence of flax root extracts at various stages of maturity on the proliferation and cytotoxicity in oestrogen-receptor-positive breast cancer cells (MCF7) in vitro. Flax root extracts were prepared by using lignan extraction. The extracted compounds were analysed by Pyrolysis-Field Ionisation Mass Spectrometry. Various extract concentrations were applied to the cells to test for proliferation (BrdU test) and cytotoxicity (LDH test). A significantly higher inhibition of cell proliferation was observed with an extract made from 9-week-old flax roots in comparison with that of 3-and 6-week-old roots. Older roots contained more lignans and other phenolic substances than younger roots. The maturity grade of plants or their various parts is thus important for the production and concentration of secondary metabolites and leads to different biological effects on breast cancer cell growth. Keywords 92

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Anti-breast cancer potential of daidzein in rodents

Cited by 65 publications

References 25 publications

The Role of Phenolic Compounds in the Fight against Cancer – A Review

The Role of Phenolic Compounds in the Fight against Cancer – A Review

Oral administration of Brazilian propolis exerts estrogenic effect in ovariectomized rats

Secondary Metabolites in Flax Root Extracts at Various Stages of Maturity and Effects on Proliferation and Cytotoxicity in Oestrogen-Receptor-Positive Breast Cancer Cells

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