Anti-cancer drugs in aquatic environment can cause cancer: Insight about mutagenicity in tadpoles

Araújo, Amanda Pereira da Costa; Mesak, Carlos; Montalvão, Mateus Flores; Freitas, Ítalo Nascimento; Chagas, Thales Quintão; Malafaia, Guilherme

doi:10.1016/j.scitotenv.2018.09.373

Cited by 36 publications

(14 citation statements)

References 57 publications

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“…In addition, compounds 6 and 7 affect the resumption of oocyte meiosis triggered by progesterone. It was previously reported that apoptosis occurred in progesterone-treated oocyte 48 h after the completion of maturation [39,40]. Two apoptosis markers, the cleaved caspase 3 [44,45] and the Ser14 phosphorylated histone H2B [44][45][46][47] were detected in prophase I oocytes exposed to compound 7 and in oocytes treated by progesterone and compounds 6 or 7 showing an apoptosis death.…”

Section: Discussionmentioning

confidence: 81%

“…The increasing use of pharmaceuticals results in increased discharges and aquatic contamination [35], for example in Brazil doses up to 123.5 µg/L were measured [39], but higher concentrations all over the world were also reported (see [40] for a review). Xenopus oocytes (M-Phase entry and meiotic maturation from prophase I to metaphase II) offer a unique physiological aquatic model to assess the effects of novel synthesized products on cell cycle.…”

Section: Discussionmentioning

confidence: 99%

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Effects of Ferrocenyl 4-(Imino)-1,4-Dihydro-quinolines on Xenopus laevis Prophase I - Arrested Oocytes: Survival and Hormonal-Induced M-Phase Entry

Marchand

Wambang²,

Pellegrini³

et al. 2020

IJMS

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Xenopus oocytes were used as cellular and molecular sentinels to assess the effects of a new class of organometallic compounds called ferrocenyl dihydroquinolines that have been developed as potential anti-cancer agents. One ferrocenyl dihydroquinoline compound exerted deleterious effects on oocyte survival after 48 h of incubation at 100 μM. Two ferrocenyl dihydroquinoline compounds had an inhibitory effect on the resumption of progesterone induced oocyte meiosis, compared to controls without ferrocenyl groups. In these inhibited oocytes, no MPF (Cdk1/cyclin B) activity was detected by western blot analysis as shown by the lack of phosphorylation of histone H3. The dephosphorylation of the inhibitory Y15 residue of Cdk1 occurred but cyclin B was degraded. Moreover, two apoptotic death markers, the active caspase 3 and the phosphorylated histone H2, were detected. Only 7-chloro-1-ferrocenylmethyl-4-(phenylylimino)-1,4-dihydroquinoline (8) did not show any toxicity and allowed the assembly of a histologically normal metaphase II meiotic spindle while inhibiting the proliferation of cancer cell lines with a low IC50, suggesting that this compound appears suitable as an antimitotic agent.

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Section: Discussionmentioning

confidence: 81%

Section: Discussionmentioning

confidence: 99%

Effects of Ferrocenyl 4-(Imino)-1,4-Dihydro-quinolines on Xenopus laevis Prophase I - Arrested Oocytes: Survival and Hormonal-Induced M-Phase Entry

Marchand

Wambang²,

Pellegrini³

et al. 2020

IJMS

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“…The 5-fluorouracil inhibits the growth of Synechococcus leopoliensis (cyanobacteria) and Pseudokirchneriella subcapitata (algae) at concentrations of 1.20 and 0.13 mg L −1 , respectively (Brezovšek et al 2014 ). Exposure to environmental concentrations of 5-fluorouracil and cyclophosphamide pollutants (0.2–123 μg L −1 ) for Lithobates catesbeianus (tadpoles) can generate morphological changes and mutagenic effects in the gastrointestinal tract via formation of binuclei and micronuclei as well as melanocytes development (Araújo et al 2019 ). The toxicity results for 5-fluorouracil and methotrexate to endemic Elliptio complanata (freshwater mussels) at the highest concentration (100 μg L −1 ) for 96 h indicate that methotrexate and 5-fluorouracil with a larger spectrum of effects can increase the dihydrofolate reductase and can decrease the DNA repair activity and lipid peroxidation (Kleinert et al 2021 ).…”

Section: Pharmaceuticalsmentioning

confidence: 99%

Remediation of pharmaceuticals from contaminated water by molecularly imprinted polymers: a review

Zare‬

Fallah

et al. 2022

Environ Chem Lett

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The release of pharmaceuticals into the environment induces adverse effects on the metabolism of humans and other living species, calling for advanced remediation methods. Conventional removal methods are often non-selective and cause secondary contamination. These issues may be partly solved by the use of recently-developped adsorbents such as molecularly imprinted polymers. Here we review the synthesis and application of molecularly imprinted polymers for removing pharmaceuticals in water. Molecularly imprinted polymers are synthesized via several multiple-step polymerization methods. Molecularly imprinted polymers are potent adsorbents at the laboratory scale, yet their efficiency is limited by template leakage and polymer quality. Adsorption performance of multi-templated molecularly imprinted polymers depends on the design of wastewater treatment plants, pharmaceutical consumption patterns and the population serviced by these wastewater treatment plants.

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“…Although the formation of these anomalies is not fully understood (Benvindo-Souza et al 2020), it does appear to re ect adverse reactions in the cells or control mechanisms used to eliminate cells with damaged DNA (Fijan 2002). The lobed and reniform nuclei do appear to be related to the precursors of micronuclei and binucleated cells, however (Araújo et al 2019). Lobed nuclei have been observed in response to exposure to environmental contaminants in a number of anuran studies (Pollo et al 2017).…”

Section: Discussion Theenvironmental and Biologicalresponses Of The Anuransmentioning

confidence: 99%

Habitat differences affect the nuclear morphology of the erythrocytes and the hepatic melanin in Leptodactylus fuscus (Anura) in the Brazilian Cerrado savanna

Assis

Rezende

Santos

et al. 2021

Environ Sci Pollut Res

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The sensitivity of anuran to the effects of habitat destruction and contamination has led to a preoccupying global decline in their populations. Morphological biomarkers such as micronuclei and other erythrocyte nuclear abnormalities (ENAs) and the occurrence of hepatic melanin can be used to evaluate the effects of habitat impacts. In the present study, these two procedures were combined for the in situ assessment of the effects of soybean cultivation on the grassfrog, Leptodactylus fuscus. Specimens were also collected from a protected area to provide a control (non-agricultural environment).The frequency of some nuclear abnormalities in the animals from the soybean plantation was much higher than the control, speci cally, micronuclei were 3.6 times more frequent, while lobulated nuclei were 3.4 times more frequent, and reniform nuclei, four times more common. The combined analysis of all the ENAs also revealed a frequency approximately 1.4 times higher in the animals from the soybean plantation, in comparison with the protected area. Smaller areas of hepatic melanin were observed in the specimens from the soybean plantation. These results provide further evidence of the sensitivity of anurans to habitat impacts, and indicate that animals found in soybean plantations are susceptible to systematic alterations of the cells.

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Anti-cancer drugs in aquatic environment can cause cancer: Insight about mutagenicity in tadpoles

Cited by 36 publications

References 57 publications

Effects of Ferrocenyl 4-(Imino)-1,4-Dihydro-quinolines on Xenopus laevis Prophase I - Arrested Oocytes: Survival and Hormonal-Induced M-Phase Entry

Effects of Ferrocenyl 4-(Imino)-1,4-Dihydro-quinolines on Xenopus laevis Prophase I - Arrested Oocytes: Survival and Hormonal-Induced M-Phase Entry

Remediation of pharmaceuticals from contaminated water by molecularly imprinted polymers: a review

Habitat differences affect the nuclear morphology of the erythrocytes and the hepatic melanin in Leptodactylus fuscus (Anura) in the Brazilian Cerrado savanna

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