ANTI DIABETIC FLAVANONE COMPOUND FROM THE LEAVES OF Artocarpus communis

Lotulung, Puspa Dewi; Fajriah, Sofa; Sundowo, Andini; Filaila, Euis

doi:10.22146/ijc.21524

Cited by 6 publications

(5 citation statements)

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“…AC-31 AC-31, AC-51, AC-33, and cyclocommunol were flavonoid compounds isolated previously from A. altilis leaves [5,[17][18][19]. AC-31 showed the lowest IC 50 compared to quercetin, AC-51, AC-33 and cyclocommunol with IC 50 value 15.73.…”

Section: Resultsmentioning

confidence: 99%

“…Metabolic factors include advanced glycation, increased formation of polyols and activation of protein kinase-C. Hemodynamic factors include systemic hypertension, intraglomerular hypertension and the role of vasoactive hormones, such as anglotensin II. Clinical course progresses from microalbuminuria to overt proteinuria and then to renal failure [5].…”

Section: Introductionmentioning

confidence: 99%

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In Vitro Antidiabetic Activities of Extract and Isolated Flavonoid Compounds from <i>Artocarpus altilis</i> (Parkinson) Fosberg

Lotulung¹,

Mozef²,

Risdian³

et al. 2014

Indones. J. Chem.

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The antidiabetic activity test through a mechanism of inhibition of α-glucosidase enzyme was studied against ethanol, n-hexane, ethyl acetate and n-butanol fractions of ethanol extract of Artocarpus altilis (Parkinson) Fosberg (Moraceae) leaves and four flavonoid compounds isolated from ethyl acetate extracts of A. altilis. Ethyl acetate fraction has strongest antidiabetic activity compared to ethanol, n-hexane, and n-butanol fractions with IC50values5.98,6.79, 440.18and14.42μg/mL, respectively. Four flavonoid compounds (1-(2,4-dihydroxyphenyl)-3-[8-hydroxy-2-methyl-2-(4-methyl-3-pentenyl)-2H-1-benzopyran-5-yl]-1-propanone (AC-31), 2-geranyl-2',3,4,4'-tetrahydroxy dihydrochalcone (AC-51), 8-geranyl-4',5,7-trihydroxyflavone (AC-33) andcyclocommunol (AA-3), have been isolated from ethylacetate fraction. AC-31 was the strongest antidiabetic compound compared to AC-51, AC-33 and cyclocommunolwithIC50values are 15.73, 24.41,49.49,and72.20μg/mL. Kineticstudies of AC-31 using Lineweaver-Burk method showed that inhibition mechanism of enzymeα-glucosidase was anon-competitivetype.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

In Vitro Antidiabetic Activities of Extract and Isolated Flavonoid Compounds from <i>Artocarpus altilis</i> (Parkinson) Fosberg

Lotulung¹,

Mozef²,

Risdian³

et al. 2014

Indones. J. Chem.

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“…In one of the study, two dihydroflavonol glycosides such as engeletin (29) and astilbin (30), isolated from the leaves of Stelechocarpus cauliflorus (family: Annonaceae), exhibited inhibitory activity against a recombinant human aldose reductase 6 .…”

Section: Fig 8: Kaempferol 3-o-β-d-glucopyranoside (Astragalin) (22a) and Quercetin 3-o-β-d-glucopyranoside (Isoquercetin) (22b)mentioning

confidence: 99%

“…Isoflavones are mainly present in the Leguminosae family, being soybean sprouts a very good source of isoflavones 6 . Leguminous plants are known for their high levels of bioactive compounds, which can enhance glucose metabolism by the following:…”

Section: Isoflavonesmentioning

confidence: 99%

Untitled

2019

IJPSR

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Diabetes is a metabolic disorder, which is characterized by insulin deficiency, insulin resistance, and aberrant metabolism in glucose, protein, and lipid. The primary causes of diabetes are Genetic and environmental factors. Diabetes is a chronic progressive disease that leads to both microvascular and macrovascular complications. This disease affects around 5% of the world population now. But, recently available oral antidiabetic agents used in orthodox medicine have unmet efficacy and undesirable side effects in patients. Therefore, Research is a significant deal requirement for the development of new remedies for diabetes are in high demand. Surveys expect that complementary and alternative medicine (CAM) is used by 80% of the world population for their primary health care. Therefore, CAM represents one of the most important options for therapy for diabetes. The objective of this work is to provide a starting point for programs leading to the development of indigenous flavonoids botanical resources as inexpensive sources for standardized crude antidiabetic drugs, and the development of lead compounds for new hypoglycemic drug development. INTRODUCTION:Complementary and Alternative Medicine (CAM): Complementary and alternative medicine (CAM) refers to a wide range of clinical therapies outside of conventional medicine. The term "complementary" is defined as therapies that are used in conjunction with conventional medicine, whereas "alternative" medicine involves therapies that are used in place of conventional medicine. Some CAM providers and researchers have advocated the term "integrative" medicine as representing a combination of conventional medicine, CAM, and evidence-based medicine 21 .

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“…In our study, we used several types of plants such as breadfruit leaves, (Artocarpus communis (Sk)) as antidiabetic 1 , cinnamon leaf (Cinnamomum verum (K)) as antidiabetic 2 , Syzygium polyanthum (Sl) bay leaf which is high in antioxidants 3 , sapodilla leaf (Manilkara zapota) (Sw) as anti-diabetic. 4 Teak extracts can be considered as one of the alternatives to chemical food preservatives and for controlling food.…”

Section: Introductionmentioning

confidence: 99%

In vitro lipase enzyme inhibitory activities of green tea and other herbs

Megawati

Artanti

Mulyani

et al. 2020

JGI

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Background: Increased lipase activity can increase the amount of monoglycerides and fatty acids absorbed by the body, this is what affects obesity. If pancreatic lipase activity is inhibited, the production of fatty acids will decrease, consequently the level of fat in the blood will also decrease.Objective: To study anti obesity potential of a single herb or a mixture of green tea and other herbs (Syzygium polyanthum. Lv, Artocarpus communis.Lv, Cinnamomum verum..Lv, Manilkara zapota.Lv, Tectona grandis.Lv) by the in vitro inhibition assay of the lipase enzyme activityMethod: A single (8 herbs) or a mixture of three herbs powder (12 formulas) was put into a tea bag with a total weight of 1.5 g to be brewed in 100 mL bottled mineral water at 70⁰-90⁰C for 10 minutes. In vitro lipase enzyme inhibition assay were conducted to measure the ability of these samples as lipase inhibitor. Orlistat used as positive lipase inhibitor. Results: There was a difference results of lipase inhibition activity between the sample of a single and a mixture of herbs. Interestingly, the results shows that formula 3 (mixture of green tea, Manilkara zapota and cinnamon). has 53.942 % inhibition, formula 9 (a mixture of green tea, Syzygium polyanthum and cinnamon) has 67.322 % inhibition and formula 12 (a mixture of green tea, Tectona grandis and cinnamon) has 56.612 % inhibition which close to lipase inhibitory activity by standard Orlistat.Conclusion: The mixture of green tea and two other herbs has a lipase inhibitory activity similar to Orlistat, when compared to the single herb. The highest lipase inhibitory activity is found in formula 9.

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ANTI DIABETIC FLAVANONE COMPOUND FROM THE LEAVES OF Artocarpus communis

Cited by 6 publications

References 0 publications

In Vitro Antidiabetic Activities of Extract and Isolated Flavonoid Compounds from <i>Artocarpus altilis</i> (Parkinson) Fosberg

In Vitro Antidiabetic Activities of Extract and Isolated Flavonoid Compounds from <i>Artocarpus altilis</i> (Parkinson) Fosberg

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In vitro lipase enzyme inhibitory activities of green tea and other herbs

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