Anti–Herpes Simplex Virus Type-1 Activity and Phenolic Content of Crude Ethanol Extract and Four Corresponding Fractions of <i>Quercus brantii</i> L Acorn

Karimi, Ali; Rafieian-Kopaei, Mahmoud; Moradi, Mohammad-Taghi; Alidadi, Somayeh

doi:10.1177/2156587216676421

Cited by 24 publications

(10 citation statements)

References 49 publications

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“…Another interesting study evaluated the anti-HSV-1 activity of the fruit chloroform extract of the flowering plant Quercus brantii Lindl. Their results verified that this extract had a high amount of condensed tannins, which exert a potent inhibitory effect (IC 50 2.9 μg/ml), they attributed that due to their ability to prevent the viral entry (Karimi et al, 2017). Arunkumar and Rajarajan (2018) performed a bioactivity-guided fractionation for the ethanolic extract of the fruit peel of Punica granatum L., where the main bioactive compound isolated was the punicalagin (PUG), which exerted a surprising result by 100% anti-HSV-2 activity at 31.25 μg/ml.…”

Section: General Antiviral Activities Of Some Medicinal Plants With a Promising Anti-covid-19 Approachmentioning

confidence: 71%

Medicinal plant-derived compounds as potential phytotherapy forCOVID-19: Future perspectives

El-Darier¹,

Rashed²,

Fayez³

et al. 2021

J. Pharmacognosy Phytother.

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Currently, the human being faces a contagious virus called SARS-CoV-2 with a high transmission ability, infection, and a relatively high mortality rate, especially for the elderly. All research interest is directed to finding a drug or vaccine to save millions of people's lives; some have succeeded and applied now in some countries. Medicinal plants represent a green treasure that renders plentiful primary and secondary metabolites characterized by potent biological activities. Interestingly, the secondary metabolites, alkaloids, flavonoids, tannins, and terpenoids, own a broad antiviral history. The plant antiviral capabilities may be due to inhibition of viral attachment to/penetration of the host cell; inhibition of the virus replication; suppressing RNA replication; downregulation of viral proteins translation; interfering with virus non-structural/structural protein; downregulation of virus-induced pro-inflammatory/inflammatory signaling pathways in the host cell, and antioxidant activity thus abating the virus-induced oxidative stress effect. Presently, as we are trapped with a surly virus, there are attempts to exploit the power of nature. Therefore, this review's main objective is to refer to some medicinal plants or their derivatives that limit the virus's virulence or alleviate the symptoms associated with this virus.

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Section: General Antiviral Activities Of Some Medicinal Plants With a Promising Anti-covid-19 Approachmentioning

confidence: 71%

Medicinal plant-derived compounds as potential phytotherapy forCOVID-19: Future perspectives

El-Darier¹,

Rashed²,

Fayez³

et al. 2021

J. Pharmacognosy Phytother.

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show abstract

“…Recently, the potential activity of Quercus brantii Lindl. fruit chloroform extract against HSV-1 was evaluated on baby hamster kidney cell line (Karimi, Rafieian-Kopaei, Moradi, & Alidadi, 2017). Results showed an IC 50 2.9 μg/ml and a selective index for HSV-1 of 53.8.…”

Section: Herpes Virusmentioning

confidence: 99%

Antiviral activity of plants and their isolated bioactive compounds: An update

Denaro

Smeriglio

Barreca

et al. 2019

Phytotherapy Research

131

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Viral infections represent one of the main causes of disease worldwide, especially today due to the increase of migration, global travel, and urbanization. The several side effects of the conventional drugs and the growing phenomenon of resistance have led researchers to turn to the plant kingdom as a source of potential new antiviral drugs. The aim of this work is to summarize the updated evidence for antiviral activity of different plants and their isolated bioactive compounds, evaluating also the potential interactions, which can occur in cotreatment with conventional antiviral drugs. The plant complexes have proved to be usually more active than their most abundant isolated compounds by hypothesizing synergistic mechanisms. In addition to cellular and molecular investigations, molecular docking studies have proved essential in highlighting the interaction mechanisms of bioactive compounds with target molecules. However, the use of nonstandardized extracts, or too high concentrations in vitro, which do not reproduce their bioavailability in vivo, are often limiting factors. Moreover, the lack of studies concerning the safety profile of plant extracts and their isolated compounds, alone or in combination with conventional antiviral drugs, is the most worrying aspect. In light of this, further studies are needed to validate their possible therapeutic use.

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“…Total phenolic and flavonoid amounts of S. aromaticum extract was 255.8±3.95 mg GAE/g and 63.9±2.35 mg RUT/g respectively. Phenolic compounds have been shown to have antibacterial and anti-viral activities [34,[37][38][39][40]. S. aromaticum is one of the richest sources of phenolic compounds such as gallic acid, eugenol and eugenol acetate [41].…”

Section: Discussionmentioning

confidence: 99%

Anti-adenovirus activity, antioxidant potential, and phenolic content of dried flower buds of Syzygium aromaticum extract in HEp2 cell line

Moradi¹,

Karimi²,

Alidadi³

et al. 2017

mpj

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The aim of this study is to evaluate in vitro anti-adenovirus property, antioxidant potential, and total phenolic content of dried flowers buds of Syzygium aromaticum crude extract. The crud extract was prepared and its anti-adenovirus activity was investigated on HEp2 cell line using MTT (3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide) assay. The 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay, Folin-Ciocalteu method and aluminum chloride colorimetric method was used to determine antioxidant activity, total phenol content, flavonoids and flavonols content of the extract, respectively. Based on results, the 50% cytotoxicity concentration (CC 50 ) and the 50% inhibitory concentration (IC 50 ) of the extract were 97.66±11.4 and 4.73±1.6 µg/ml, respectively, with the selectivity index (SI) of 20.64. The crud extract inhibited adenovirus replication in post-adsorption step (p<0.05). The extract showed remarkable scavenging activity with IC 50 values of 10.05±1.93 μg/ml. Total phenolic, flavonoid and flavonol content of the crude extract was 255.8±3.95 mg GAE/g, 63.9±2.35 mg RUT/g and 62±2.35 mg RUT/g, respectively. The results of the present study indicated that S. aromaticum crude extract exhibited anti-adenovirus activity with inhibitory effect on adenovirus replication could be considered as a potential anti-adenovirus agents.

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Anti–Herpes Simplex Virus Type-1 Activity and Phenolic Content of Crude Ethanol Extract and Four Corresponding Fractions of Quercus brantii L Acorn

Cited by 24 publications

References 49 publications

Medicinal plant-derived compounds as potential phytotherapy forCOVID-19: Future perspectives

Medicinal plant-derived compounds as potential phytotherapy forCOVID-19: Future perspectives

Antiviral activity of plants and their isolated bioactive compounds: An update

Anti-adenovirus activity, antioxidant potential, and phenolic content of dried flower buds of Syzygium aromaticum extract in HEp2 cell line

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