Anti-hyperglycemic and antigenotoxic potential of Ulva rigida ethanolic extract in the experimental diabetes mellitus

Çelikler, Serap; Taş, Sibel; Vatan, Özgür; Ziyanok-Ayvalik, Sedef; Yıldız, Gamze; Bilaloĝlu, Rahmi

doi:10.1016/j.fct.2009.04.039

Cited by 56 publications

(28 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In line with our previous report 14 we observed that blood glucose levels decreased and plasma insulin levels increased after U. rigida administration. We have also observed an increased body weight and reduced fluid and food intake in the D þ URE group, which seems to be a result of U. rigida's ability to improve carbohydrate metabolism.…”

Section: Discussionsupporting

confidence: 93%

Ulva rigida improves carbohydrate metabolism, hyperlipidemia and oxidative stress in streptozotocin‐induced diabetic rats

Taş

Çelikler

Ziyanok-Ayvalik

et al. 2011

Cell Biochemistry & Function

Self Cite

View full text Add to dashboard Cite

This study was designed to investigate the effects of Ulva rigida, one of the green algae, on the lipid profile and oxidative-antioxidative systems in streptozotocin-induced diabetic rats. Forty Wistar rats randomly divided into four groups: control (C), control + U. rigida extract (C + URE), diabetes (D) and diabetes + U. rigida extract (D + URE). U. rigida (2%) was administered in drinking water for 5 weeks after the induction of diabetes. U. rigida reduced the blood glucose, serum total cholesterol, triglyceride levels and plasma and tissue malondialdehyde (MDA) levels in the D + URE group. Insulin levels were significantly higher in the D + URE than those of the D group. Serum total cholesterol and tissue MDA levels were reduced in the C + URE group. Whole blood glutathione peroxidase and erythrocyte superoxide dismutase activities were higher in the D and C + URE groups compared with the C group. Paraoxonase and arylesterase activities were lower in the D group while U. rigida increased paraoxonase activities in C + URE and D + URE groups. This is the first study which showed U. rigida has antidiabetic and antihyperlipidemic effects and improves oxidative stress in diabetic rats. We conclude that U. rigida might have a potential use as a protective and/or therapeutic agent in diabetes mellitus.

show abstract

Section: Discussionsupporting

confidence: 93%

Ulva rigida improves carbohydrate metabolism, hyperlipidemia and oxidative stress in streptozotocin‐induced diabetic rats

Taş

Çelikler

Ziyanok-Ayvalik

et al. 2011

Cell Biochemistry & Function

Self Cite

View full text Add to dashboard Cite

show abstract

“…The cell suspension was smeared on glass slide and air dried. They were stained successively with May-Gruenwald and Giemsa stain for detecting micronucleated polychromatic erythrocytes (MNPCEs) (Salamone &Mavourin, 2005 andCelikler et al, 2009). The normochromatic erythrocytes (NCEs) were also scored and the frequency of PCE among the first 200 NCEs were counted using Leica microscope with plain objective at 100Â/1.25 oil mount magnification, to calculate the PCE/NCE ratio.…”

Section: Rodent Bone Marrow Micronucleus Testmentioning

confidence: 99%

Dose-dependent effect in the inhibition of oxidative stress and anticlastogenic potential of ginger in STZ induced diabetic rats

et al. 2012

View full text Add to dashboard Cite

“…The biological activity of fucoidan has been reported to be closely related to molecular weight [16,17]. A few report showed seaweed extracts having a potential anti-diabetes activity [18]. However, it has not been clearly investigated the effect of different molecular weight fucoidan on hyperglycemia on diabetes.…”

Section: Introductionmentioning

confidence: 98%

Fucoidan regulate blood glucose homeostasis in C57BL/KSJ m+/+db and C57BL/KSJ db/db mice

2012

View full text Add to dashboard Cite

Anti-hyperglycemic and antigenotoxic potential of Ulva rigida ethanolic extract in the experimental diabetes mellitus

Cited by 56 publications

References 21 publications

Ulva rigida improves carbohydrate metabolism, hyperlipidemia and oxidative stress in streptozotocin‐induced diabetic rats

Ulva rigida improves carbohydrate metabolism, hyperlipidemia and oxidative stress in streptozotocin‐induced diabetic rats

Dose-dependent effect in the inhibition of oxidative stress and anticlastogenic potential of ginger in STZ induced diabetic rats

Fucoidan regulate blood glucose homeostasis in C57BL/KSJ m+/+db and C57BL/KSJ db/db mice

Contact Info

Product

Resources

About