Anti-hyperglycemic, pathogenic and anticancer activities of Bambusa arundinacea mediated Zinc Oxide nanoparticles

Jayarambabu, N.; Rao, T. Venkatappa; Kumar, Rajeev; Akshaykranth, A.; Shanker, Kalakotla; Suresh, Velpula

doi:10.1016/j.mtcomm.2020.101688

Cited by 17 publications

(7 citation statements)

References 21 publications

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“…Even though ZnO nanoparticles are known for its biocompatible nature, previous studies have reported both biocompatibility and anticancer activities against mammalian cells. 115,116 In this study, the cytotoxicity studies of ZnO nanoparticles synthesized using B. orellana leaf, seed, and seed coat extracts were analyzed before and after calcination against HCT-116 cancer cells using trypan blue staining as represented in Figure 12. Cytotoxicity studies were performed using these biosynthesized ZnO nanoparticles at a concentration of 100 μg/mL before and after calcination in triplicates.…”

Section: Resultsmentioning

confidence: 99%

Non-antimicrobial and Non-anticancer Properties of ZnO Nanoparticles Biosynthesized Using Different Plant Parts of Bixa orellana

2022

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As traditional cancer therapy is toxic to both normal and cancer cells, there is a need for newer approaches to specifically target cancer cells. ZnO nanoparticles can be promising due their biocompatible nature. However, ZnO nanoparticles have also shown cytotoxicity against mammalian cells in some cases, because of which there is a need for newer synthesis approaches for biocompatible ZnO nanoparticles to be used as carrier molecules in drug delivery applications. Here, we report the biosynthesis of ZnO nanoparticles using different plant parts (leaf, seed, and seed coat) of Bixa orellana followed by different characterizations. The UV−visible spectra of ZnO showed absorption maxima at 341 and 353 nm, 378 and 373 nm, and 327 and 337 nm, respectively, before and after calcination corresponding to the band gap energy of 3.636 and 3.513 eV, 3.280 and 3.324 eV, and 3.792 and 3.679 eV for L-ZnO, S-ZnO, and Sc-ZnO, respectively. Xray diffraction analysis confirmed the formation of hexagonal wurtzite structures. Attenuated total reflectance infrared spectra revealed the presence of stretching vibrations of C−C, CC, CO, and NH 3 + groups along with C−H deformation involving biomolecules from extracts responsible for reduction and stabilization of nanoparticles. Field emission scanning electron microscopy and transmission electron microscopy images showed spherical and almond-like morphologies of L-ZnO and Sc-ZnO with spherical morphologies, whereas S-ZnO showed almond-like morphologies. The presence of antibacterial activity was observed in L-ZnO against Staphylococcus aureus and Bacillus subtilis, in S-ZnO nanoparticles only against Escherichia coli, and in Sc-ZnO only against Staphylococcus aureus. Uncalcinated ZnO nanoparticles showed weak antibacterial activities, whereas calcinated ZnO nanoparticles showed a non-antibacterial nature. The antifungal activity against different fungi (Penicillium sp., Aspergillus flavus, Fusarium oxysporum, and Rhizoctonia solani) and cytotoxicity against HCT-116 cancer cells were not observed before and after calcination in all three ZnO nanoparticles. The antimicrobial nature and biocompatibility of ZnO nanoparticles were influenced by different parameters of the nanoparticles along with microorganisms and the human cells. Non-antimicrobial properties of ZnO nanoparticles can be treated as a pre-requisite for its biocompatibility due to its inert nature. Thus, biosynthesized ZnO nanoparticles showed a nontoxic nature, which can be exploited as promising alternatives in biomedical applications.

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Section: Resultsmentioning

confidence: 99%

Non-antimicrobial and Non-anticancer Properties of ZnO Nanoparticles Biosynthesized Using Different Plant Parts of Bixa orellana

2022

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“…The upper section of bamboo shoots has been proven to possess unusually high levels of ACh 164 . The administration of the leaves, either by infusion or direct consumption, has exerted anti-inflammatory, antioxidant, diuretic, expectorant, and anticarcinogenic properties 165 , 166 .…”

Section: Chinese Medicinal Plantsmentioning

confidence: 99%

The neuroprotective effect of traditional Chinese medicinal plants—A critical review

Moreira

Machado

Dias-Teixeira

et al. 2023

Acta Pharmaceutica Sinica B

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“…Qurse Tabasheer contains six ingredients, namely, Tabasheer (Siliceous concretions) ( Bambosa arundinaceae Retz.) ( Jayarambabu et al, 2021 ), GuleSurkh ( Rosa damascena Mill . flower) ( Gholamhoseinian and Fallah 2009 ), Gulnar ( Punica granatum Linn.…”

Section: Methodsmentioning

confidence: 99%

Common Ayurvedic, Chinese traditional and Unani antidiabetic formulations- a review

Murudkar

Tambe²,

Chandrasekar³

et al. 2022

Front. Pharmacol.

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Diabetes mellitus is the most widely recognized endocrine disorder which is influencing a bigger populace on the planet. There are various causes of diabetes, such as physical inactivity, obesity, family history, race, and age. Diabetes mellitus is associated with some life-threatening complications, such as neuropathy, nephropathy, various eye diseases or retinopathy, and cardiovascular disorders. Many synthetic antihyperglycemic agents are available in the market for the treatment of diabetes and its complications. But, due to some serious side effects of these synthetic agents, people are opting for herbal remedies and, therefore, they are now becoming popular. Herbal remedies have lesser side effects and higher affordability and therefore can be preferably used over synthetic agents for a long-term disorder like diabetes mellitus. In the present study, scientific research and review studies on the topic were collected from Science Direct, Scopus, PubMed, Google Scholar, and other relevant sources. The references of all the articles were screened manually for any additional information on popular polyherbal formulations in traditional Ayurvedic, Chinese, and Unani medicinal systems. It is found that these polyherbal formulations are studied for anti-diabetic potential. Furthermore, some are also investigated for mechanism of action of anti-diabetic effects. This review highlights various Ayurvedic, Chinese, and Unani polyherbal formulations commonly utilized in the management of diabetes mellitus along with their pre-clinical and clinical investigations, which will enhance the existing knowledge of the researchers.

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Anti-hyperglycemic, pathogenic and anticancer activities of Bambusa arundinacea mediated Zinc Oxide nanoparticles

Cited by 17 publications

References 21 publications

Non-antimicrobial and Non-anticancer Properties of ZnO Nanoparticles Biosynthesized Using Different Plant Parts of Bixa orellana

Non-antimicrobial and Non-anticancer Properties of ZnO Nanoparticles Biosynthesized Using Different Plant Parts of Bixa orellana

The neuroprotective effect of traditional Chinese medicinal plants—A critical review

Common Ayurvedic, Chinese traditional and Unani antidiabetic formulations- a review

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