Anti-hyperuricemic effect of &lt;i&gt;Plantago depressa&lt;/i&gt; Willd extract in rats

Xia, Ning; Li, Bao-an; Liu, Haiju; Fan, Jiubo; Shen, Wei; He, Xiu-guo

doi:10.4314/tjpr.v16i6.21

Cited by 7 publications

(4 citation statements)

References 12 publications

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“…lessen 67% risk while the other CHM showed 56%. Though no direct study of Plantago asiatica L. related to DN was done, other studies showed that it exerted an anti-hyperuricemic effect ( Xia et al, 2017 ) and helped regulate cholesterol, triglyceride, low-density lipoprotein cholesterol, and free fatty acid in obese and metabolic abnormal mice induced by high-fat diet ( Yang et al, 2017 ). The fifth cluster with core CHM of Salvia miltiorrhiza Bunge had aHR of 0.28, and the other CHM was 0.48.…”

Section: Discussionmentioning

confidence: 99%

Associations Between Using Chinese Herbal Medicine and Long-Term Outcome Among Pre-dialysis Diabetic Nephropathy Patients: A Retrospective Population-Based Cohort Study

et al. 2021

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Background: Chronic kidney disease (CKD) has become a worldwide burden due to the high co-morbidity and mortality. Diabetic nephropathy (DN) is one of the leading causes of CKD, and pre-dialysis is one of the most critical stages before the end-stage renal disease (ESRD). Although Chinese herbal medicine (CHM) use is not uncommon, the feasibility of using CHM among pre-dialysis DN patients remains unclear.Materials and methods: We analyzed a population-based cohort, retrieved from Taiwan’s National Health Insurance Research Database, to study the long-term outcome of using CHM among incident pre-dialysis DN patients from January 1, 2004, to December 31, 2007. All patients were followed up to 5 years or the occurrence of mortality. The risks of all-cause mortality and ESRD were carried out using Kaplan-Meier and competing risk estimation, respectively. Further, we demonstrated the CHM prescriptions and core CHMs using the Chinese herbal medicine network (CMN) analysis.Results: A total of 6,648 incident pre-dialysis DN patients were analyzed, including 877 CHM users and 5,771 CHM nonusers. With overlap weighing for balancing all accessible covariates between CHM users and nonusers, we found the use of CHM was associated with lower all-cause mortality (0.22 versus 0.56; log-rank test: p-value <0.001), and the risk of mortality was 0.42 (95% CI: 0.36–0.49; p-value <0.001) by adjusting all accessible covariates. Further, the use of CHM was associated with a lower risk of ESRD (cause-specific hazard ratio: 0.59, 95%CI: 0.55–0.63; p-value <0.001). Also, from the 5,901 CHM prescriptions, we found Ji-Sheng-Shen-Qi-Wan, Astragalus mongholicus Bunge or (Astragalus membranaceus (Fisch.) Bge.), Plantago asiatica L. (or Plantago depressa Willd.), Salvia miltiorrhiza Bunge, and Rheum palmatum L. (or Rheum tanguticum (Maxim. ex Regel) Balf., Rheum officinale Baill.) were used as core CHMs for different CHM indications. Use of core CHMs was associated with a lower risk of mortality than CHM users without using core CHMs.Conclusions: The use of CHM seemed feasible among pre-dialysis DN patients; however, the beneficial effects still need to be validated by well-designed clinical trials.

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Section: Discussionmentioning

confidence: 99%

Associations Between Using Chinese Herbal Medicine and Long-Term Outcome Among Pre-dialysis Diabetic Nephropathy Patients: A Retrospective Population-Based Cohort Study

et al. 2021

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“…Compound 33 showed the same molecular ions and fragment ions with those of 6-hydroxyapigenin-7-O-glucoside (27); therefore, it could be identified as 6-hydroxyapigenin-4′-O-glucoside [33]. 7, p-hydroxybenzoic acid (9), caffeic acid (11), syringic acid (12), and ferulic acid (21) have been found in the other species of Plantago genus (e.g., P. major, P. asiatica) [12], and cis-3-O-caffeoylquinic acid (6) was reported in Plantago family for the first time. [29].…”

Section: Identification Of Phenylethanoid Glycosidesmentioning

confidence: 97%

“…Fresh leaves of Cheqian Cao are used in fresh salads and soups. Modern pharmaceutical studies reveal that plantaginis has antioxidant, anti-inflammatory, antidiabetes, and anti-hyperuricemic properties [9][10][11]. And phytochemical investigations report the existence of polyphenols in plantaginis, such as flavonoids, phenylethanoid glycosides, and organic acids [12].…”

Section: Introductionmentioning

confidence: 99%

Comprehensive Polyphenolic Profile of Plantago depressa using High‐Speed Countercurrent Chromatography Off‐line with High‐Performance Liquid Chromatography–Diode Array Detector–Quadrupole Time‐of‐flight Tandem Mass Spectrometry

Xu¹,

Tong²,

Fu³

et al. 2019

eFood

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The whole plant of Plantago depressa is commonly used as traditional Chinese medicine and functional food ingredient. Total phenolic content and total flavonoid content evaluation indicated that its ethyl acetate and n-butanol fractions were rich in polyphenols. However, to date, the polyphenolic profile is limited because of the complex matrix. Here, polyphenols in ethyl acetate and n-butanol fractions of P. depressa were first separated and enriched by High-Speed Countercurrent Chromatography (HSCCC). Then, their structures were characterized or tentatively identified by High-Performance Liquid Chromatography (HPLC)-Diode Array Detector (DAD)-Quadrupole Time-of-Flight Tandem Mass Spectrometry (QTOF-MS/MS) (HSCCC × HPLC-DAD-QTOF-MS/MS). Because of the orthogonality of HSCCC and HPLC, 37 polyphenols were identified. Notably, 29 polyphenols were discovered from P. depressa for the first time. Finally, contents of two potential new compounds, 2-ethoxy plantamajoside isomers (17 and 29), were determined as 0.27 ± 0.03 and 0.04 ± 0.01 mg/g, respectively. Results indicated that P. depressa could be used as a promising source of polyphenols for health promotion, and the developed method (HSCCC × HPLC) was efficient to explore polyphenolic profile for complex natural products.

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“…In the traditional treatment, plantain has been used in the clinical treatment of gout and hyperuricemia with remarkable effect. Modern studies have also shown that plantain has the effect of reducing serum UA [ 10 , 11 ], anti-inflammatory and analgesic [ 12 , 13 ], inhibiting xanthine oxidase (XOD) activity [ 14 ], and protecting the kidney [ 15 ]. However, the mechanism of plantain to treat gout and hyperuricemia is still unclear, especially the molecular target mechanism of its effective chemical components, such as specific targets and pathways, which needs to be further explored.…”

Section: Introductionmentioning

confidence: 99%

Potential Molecular Mechanisms of Plantain in the Treatment of Gout and Hyperuricemia Based on Network Pharmacology

Liu

Shi

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Background. The incidence of gout and hyperuricemia is increasing year by year in the world. Plantain is a traditional natural medicine commonly used in the treatment of gout and hyperuricemia, but the molecular mechanism of its active compounds is still unclear. Based on network pharmacology, this article predicts the targets and pathways of effective components of plantain for gout and hyperuricemia and provides effective reference for clinical medication. Method. Traditional Chinese medicine systems pharmacology database and analysis platform (TCMSP) and SymMap databases were used to screen out the active compounds and their targets in plantain. GeneCards, Therapeutic Target Database (TTD), and Online Mendelian Inheritance in Man (OMIM) databases were used to find the targets corresponding to gout and hyperuricemia. Venn diagram was used to obtain the intersection targets of plantain and diseases. The interaction network of the plantain active compounds-targets-pathways-diseases was constructed by using Cytoscape 3.7.2 software. Finally, Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses were carried out. Result. Seven active compounds were identified by network pharmacological analysis, including dinatin, baicalein, baicalin, sitosterol, 6-OH-luteolin, stigmasterol, and luteolin. Plantain plays a role in gout and hyperuricemia diseases by regulating various biological processes, cellular components, and molecular functions. The core targets of plantain for treating gout are MAPK1, RELA, TNF, NFKBIA, and IFNG, and the key pathways are pathways in cancer, hypoxia-inducible factor-1 (HIF-1) signaling pathway, interleukin (IL)-17 signaling pathway, Chagas disease (American trypanosomiasis), and relaxin signaling pathway. The core targets of plantain for hyperuricemia are RELA, MAPK1, NFKBIA, CASP3, CASP8, and TNF, and the main pathways are pathways in cancer, apoptosis, hepatitis B, IL-17 signaling pathway, and toxoplasmosis. Conclusion. This study explored the related targets and mechanisms of plantain for the treatment of gout and hyperuricemia from the perspective of network pharmacological analysis, reflecting the characteristics of multiple components, multiple targets, and multiple pathways, and it provides a good theoretical basis for the clinical application of plantain.

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Anti-hyperuricemic effect of <i>Plantago depressa</i> Willd extract in rats

Abstract: (BUN, 9.58 ± 0.72 mmol/L, p < 0.05), but increased levels of urine uric acid (39.23 ± 8.22 mg/L, p < 0.05) and urine creatinine (32.24 ± 1.69 mmol/L, p < 0.05)

Cited by 7 publications

References 12 publications

Associations Between Using Chinese Herbal Medicine and Long-Term Outcome Among Pre-dialysis Diabetic Nephropathy Patients: A Retrospective Population-Based Cohort Study

Associations Between Using Chinese Herbal Medicine and Long-Term Outcome Among Pre-dialysis Diabetic Nephropathy Patients: A Retrospective Population-Based Cohort Study

Comprehensive Polyphenolic Profile of Plantago depressa using High‐Speed Countercurrent Chromatography Off‐line with High‐Performance Liquid Chromatography–Diode Array Detector–Quadrupole Time‐of‐flight Tandem Mass Spectrometry

Potential Molecular Mechanisms of Plantain in the Treatment of Gout and Hyperuricemia Based on Network Pharmacology

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