Anti-inflammatory activity of curcumin-loaded solid lipid nanoparticles in IL-1β transgenic mice subjected to the lipopolysaccharide-induced sepsis

Wang, Jiao; Wang, Haoyue; Zhu, Rongrong; Liu, Qiang; Fei, Jian; Wang, Shilong

doi:10.1016/j.biomaterials.2015.02.116

Cited by 170 publications

(87 citation statements)

References 62 publications

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“…HU-211 as a low-toxic antidepressant was used in brain diseases; its low stability in biological systems hindered its clinical use. 49 Our previous studies demonstrated that Cur/SLNs showed great potential in anti-inflammatory activity; 39,50 however, its potential to cross BBB and treat major depression is still unknown. In this study, we introduced a highly lipophilic drug HU-211 associated with Cur/SLNs to form a new dual-drug nanoparticle (Cur/SLNs-HU-211) with the hope of enhancing the ability of Cur/SLNs to cross BBB and precisely target the disease lesions.…”

Section: Discussionmentioning

confidence: 99%

Antidepressant effects of curcumin and HU-211 coencapsulated solid lipid nanoparticles against corticosterone-induced cellular and animal models of major depression

Zhu

Wang

et al. 2016

IJN

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Major depression is a complex neuropsychiatric disorder with few treatment approaches. The use of nontargeted antidepressants induced many side effects with their low efficacy. A more precise targeting strategy is to develop nanotechnology-based drug delivery systems; hence, we employed solid lipid nanoparticles (SLNs) to encapsulate HU-211 and curcumin (Cur). The antidepressant effects of the dual-drug nanoparticles (Cur/SLNs-HU-211) for major depression treatment were investigated in corticosterone-induced cellular and animal models of major depression. Cur/SLNs-HU-211 can effectively protect PC12 cells from corticosterone-induced apoptosis and can release more dopamine, which may be associated with the higher uptake of Cur/SLNs-HU-211 shown by cellular uptake behavior analysis. Additionally, Cur/SLNs-HU-211 significantly reduced the immobility time in forced swim test, enhanced fall latency in rotarod test, and improved the level of dopamine in mice blood. Cur/SLNs-HU-211 can deliver more Cur to the brain and thus produce a significant increase in neurotransmitters level in brain tissue, especially in the hippocampus and striatum. The results of Western blot and immunofluorescence revealed that Cur/SLNs-HU-211 can significantly enhance the expression of CB1, p-MEK1, and p-ERK1/2. Our study suggests that Cur/SLNs-HU-211 may have great potential for major depression treatment.

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Section: Discussionmentioning

confidence: 99%

Antidepressant effects of curcumin and HU-211 coencapsulated solid lipid nanoparticles against corticosterone-induced cellular and animal models of major depression

Zhu

Wang

et al. 2016

IJN

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“…16,30 Different aspects should be taken into account when selecting nanodelivery system, including suitable polymer fonts, support stability, chemotherapeutic drug solubility, and so on. As a biodegradable nanometer material, MPEG-PLA micelle has shown promising drug EE, high stability, and low toxicity in drug delivery in previous anticancer research.…”

Section: Discussionmentioning

confidence: 99%

Biodegradable micelles enhance the antiglioma activity of curcumin in vitro and in vivo

Zheng

Gao

Liu

et al. 2016

IJN

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Curcumin (Cur), a natural polyphenol of Curcuma longa , has been recently reported to possess antitumor activities. However, due to its poor aqueous solubility and low biological availability, the clinical application of Cur is quite limited. The encapsulation of hydrophobic drugs into nanoparticles is an effective way to improve their pharmaceutical activities. In this research, nanomicelles loaded with Cur were formulated by a self-assembly method with biodegradable monomethoxy poly(ethylene glycol)-poly(lactide) copolymers (MPEG-PLAs). After encapsulation, the cellular uptake was increased and Cur could be released from MPEG-PLA micelles in a sustained manner. The Cur-loaded MPEG-PLA micelles (Cur/MPEG-PLA micelles) exhibited an enhanced toxicity on C6 and U251 glioma cells and induced more apoptosis on C6 glioma cells compared with free Cur. Moreover, the therapy efficiency of Cur/MPEG-PLA micelles was evaluated at length on a nude mouse model bearing glioma. The Cur/MPEG-PLA micelles were more effective on suppressing tumor growth compared with free Cur, which indicated that Cur/MPEG-PLA micelles improved the antiglioma activity of Cur in vivo. The results of immunohistochemical and immunofluorescent analysis indicated that the induction of apoptosis, antiangiogenesis, and inhibition of cell proliferation may contribute to the improvement in antiglioma effects. Our data suggested that Cur/MPEG-PLA may have potential clinic applications in glioma therapy.

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“…Figure 3b and Table S1 (Supporting Information) demonstrated that the accuracy has no significant difference when the self‐fluorescence channel was added to consideration. Furthermore, we chose the well‐proved LDH‐VP16 and SLN‐Cur in our lab to test if our method was capable to function without influence 23, 24. LDHs are classical inorganic functional materials, the LDH‐VP16 delivery system displays a scroll shape, while SLNs are nanoparticles mainly formed by solid lipids and the drug carrier system generally shows spherical shape as transmission electron microscopy (TEM) images shown in Figure 1a 7, 24.…”

Section: Resultsmentioning

confidence: 99%

“…Furthermore, we chose the well‐proved LDH‐VP16 and SLN‐Cur in our lab to test if our method was capable to function without influence 23, 24. LDHs are classical inorganic functional materials, the LDH‐VP16 delivery system displays a scroll shape, while SLNs are nanoparticles mainly formed by solid lipids and the drug carrier system generally shows spherical shape as transmission electron microscopy (TEM) images shown in Figure 1a 7, 24. Recent studies reveal that the morphology and composition have an impact on the action of nanomaterials, the complex interactions may confuse the evaluation progress setting of experimenters 25.…”

Section: Resultsmentioning

confidence: 99%

DeepScreen: An Accurate, Rapid, and Anti‐Interference Screening Approach for Nanoformulated Medication by Deep Learning

et al. 2018

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Accuracy of current efficacy judgment methods for nanoformulated drug remains unstable due to the interference of nanocarriers. Herein, DeepScreen, a drug screening system utilizing convolutional neural network based on flow cytomerty single‐cell images, is introduced. Compared to existing experimental approaches, the high‐throughput system has superior precision, rapidity, and anti‐interference, and is cost‐cutting with high accuracy. First, it can resist most disturbances from manual factors of complicated evaluation progress. In addition, class activation maps generated from DeepScreen indicate that it may identify and locate the tiny variation from cell apoptosis and slight changes of cellular period caused by drug or even nanoformulated drug action at very early stages. More importantly, the excellent performance of assessment on two types of nanoformulations and fluorescent drug proves the fine generality and anti‐interference of this novel system. All these privileged performances make DeepScreen a very smart and promising system for drug detection.

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Anti-inflammatory activity of curcumin-loaded solid lipid nanoparticles in IL-1β transgenic mice subjected to the lipopolysaccharide-induced sepsis

Cited by 170 publications

References 62 publications

Antidepressant effects of curcumin and HU-211 coencapsulated solid lipid nanoparticles against corticosterone-induced cellular and animal models of major depression

Antidepressant effects of curcumin and HU-211 coencapsulated solid lipid nanoparticles against corticosterone-induced cellular and animal models of major depression

Biodegradable micelles enhance the antiglioma activity of curcumin in vitro and in vivo

DeepScreen: An Accurate, Rapid, and Anti‐Interference Screening Approach for Nanoformulated Medication by Deep Learning

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