Anti-inflammatory and Anti-oxidant Properties of Curcuma longa (Turmeric) Versus Zingiber officinale (Ginger) Rhizomes in Rat Adjuvant-Induced Arthritis

Ramadan, Gamal; Alkahtani, Mohammed Ali; El‐Sayed, Wael M.

doi:10.1007/s10753-010-9278-0

Cited by 150 publications

(98 citation statements)

References 45 publications

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“…5 It has been reported to have a wide range of activities like anti-inflammatory, anti-oxidant, anti-parasitic, anti-mutagenic, anti-cancer, and anti-arthritic (both in vitro and in vivo), as suggested by many studies. [6][7][8][9][10][11][12] It has also been used in wound healing and as dietary supplement for arthritis in traditional medicine. The wide use of this drug, however, is limited by poor oral bioavailability due to extensive hepatic metabolism, low gastrointestinal absorption, and rapid elimination.…”

Section: Introductionmentioning

confidence: 99%

Curcumin-loaded colloidal carrier system: formulation optimization, mechanistic insight, ex vivo and in vivo evaluation

Naz¹,

Ahmad²

2015

IJN

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The present work investigated the topical delivery potential of nanoemulsion gel loaded with curcumin (CR). CR nanoemulsion (CR-NE) was prepared by spontaneous emulsification method using oil (Labrafac PG/glyceryl triacetate), surfactant:cosurfactant (S mix ) (tween 80/polyethylene glycol [PEG] 400) and water. The pseudo-ternary phase diagrams were constructed and thermodynamic stability testing was performed. Droplet size and zeta potential were evaluated using photon correlation spectroscopy and transmission electron spectroscopy. Six formulations selected with an average droplet size ≤70±2.72 nm showed a fourfold increase in skin permeation as compared to crude CR solution in oil. The formulation CR-NE4 having a flux of 117.04±2.32 µg/cm 2 /h and with maximum retention (42.87%) was selected, characterized (droplet size =41.13±3.34 nm and zeta potential =−33.1±1.45 mV), and incorporated into gel using carbopol-980 (1% w/v). Skin dynamics analyzed by confocal laser scanning microscopy showed maximum deposition of CR up to a depth of 86.98 µm and was in concordance with differential scanning calorimetry and Fourier transform infrared spectroscopy studies that confirmed lipid bilayer disruption, enhancing permeation. A 28-day anti-arthritic evaluation (body weight, paw edema, tibiotarsal joint thickness, TNF-α and IL-1β levels, and histopathology) on Freund’s complete adjuvant induced arthritic rat model after topical application of CR-NE gel in Wistar rats demonstrated substantial reversal of arthritic symptoms. Thus, CR-NE gel possesses potential for therapeutic effects locally in inflammatory arthritic disorders with improved topical bioavailability.

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Section: Introductionmentioning

confidence: 99%

Curcumin-loaded colloidal carrier system: formulation optimization, mechanistic insight, ex vivo and in vivo evaluation

Naz¹,

Ahmad²

2015

IJN

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“…(25) . Referentes aos 19 estudos restantes foram abordadas as seguintes propriedades terapêuticas com pesquisas envolvendo o gengibre: tratamento da náusea induzida por quimioterapia (26) , função para absorção de Ferro, Zinco e Cálcio (27) , analgésico (28) , antidependência contra o uso crônico da morfina (29) , anti-inflamatório (30) , antimicrobiano (31) , combate à ação da artrite reumatoide (32) , aumento da proteólise muscular em patos (33) , tratamento do câncer de mama (14) , citoprotetor (15) , combate ao vírus sincicial respiratório humano (VSR) (34) , combate a sintomas da Doença de Alzheimer (35) , tratamento da fibrose hepática (36) , proteção contra a genotoxicidade (37) , inibição da enzima Angiotensina I (38) , inibição da motilidade do cólon (39) , atenuação da isquemia cerebral (40) , redução da nefrotoxicidade (41) e neuroprotetor (42) , as quais tiveram um estudo cada publicadas durante o período de análise.…”

Section: Resultsunclassified

Análise Sistemática Da Produção Científica Do Zingiber Officinale Roscoe Após a Criação Da Relação Nacional De Plantas Medicinais De Interesse Ao Sistema Único De Saúde

Marmitt¹,

Rempel²,

Goettert³

et al. 2015

ACS

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Arq. Ciênc. Saúde. 2015 out-dez; 22(4) xx-xx Análise sistemática da produção científica do Zingiber Officinale roscoe após a criação da relação nacional de plantas medicinais de interesse ao sistema único de saúde Descritores: Gengibre; Uso Terapêutico; Atenção Primária à Saúde. AbstractIntroduction: Ginger (Zingiber officinale Roscoe) is a native plant from Asia that has been used as a spice and medicinal compound for thousands of years. Many of its compounds have been isolated, identified, and studied due to their pharmacological effects. Objectives: Quantify clinical trials reporting some form of therapeutic action from the use of Z. officinale plant, which are listed on the National Medicinal Plants of Interest to the Unified Health System published between 2010 and 2013 in three scientific databases (SciELO, Science Direct and Springer). Material and Methods: We searched databases using the key search term "Zingiber officinale Roscoe." A total of 757 articles were retrieved. We selected the studies dealing specifically with the term "Zingiber officinale" or related terms such as "ginger," "gingerol," "gingerols," "ginger," and "ginger". Reading the Abstract, we selected those that reported some kind of therapeutic treatment. In the last phase, the selected articles were fully read to search those proving therapeutic potentials from the study of Z. officinale. Results: Thirty articles were included in this review. Six studies reported the antioxidant activity representing the most cited therapy. Conclusion: With the results, it is expected to be possible to guide further research on the species in question, including other diseases not yet explored.Descriptors: Ginger; Therapeutic Use; Primary Health Care.

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“…These effects are comparable with indomethacin, an NSAID. 53 Inhibition of acetic-acid-induced writhing response and formalin-induced licking time in the late phase was shown with intraperitoneal administration of [6]-gingerol in the range of 25-50 mg/kg. Further, [6]-gingerol at a range of 50-100 mg/kg has also produced an inhibition of paw edema induced by carrageenin, suggesting that [6]-gingerol possesses analgesic and antiinflammatory activities.…”

Section: Anti-inflammatory Propertiesmentioning

confidence: 99%

Recent perspectives on the medicinal potential of ginger

Gunathilake¹,

Rupasinghe²

2015

BTAT

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Ginger (Zingiber officinale) is a globally known food and flavoring ingredient which is also reputed for its wide range of medicinal properties. The rhizome of ginger consists of a unique homologous series of compounds, gingerols, which are the major phenolic plant secondary metabolites responsible for its unique flavor and health benefits. Over the last 2 decades, extensive research has been conducted to identify bioactive constituents and medicinal potential of ginger. This review deliberates chemical composition as well as the most recent research findings on potential health benefits of ginger, including its antimicrobial, anti-inflammatory, blood pressure-lowering, cholesterol-lowering, antiplatelet aggregation, chemopreventive, antioxidant, and hypoglycemic properties.

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Anti-inflammatory and Anti-oxidant Properties of Curcuma longa (Turmeric) Versus Zingiber officinale (Ginger) Rhizomes in Rat Adjuvant-Induced Arthritis

Cited by 150 publications

References 45 publications

Curcumin-loaded colloidal carrier system: formulation optimization, mechanistic insight, ex vivo and in vivo evaluation

Curcumin-loaded colloidal carrier system: formulation optimization, mechanistic insight, ex vivo and in vivo evaluation

Análise Sistemática Da Produção Científica Do Zingiber Officinale Roscoe Após a Criação Da Relação Nacional De Plantas Medicinais De Interesse Ao Sistema Único De Saúde

Recent perspectives on the medicinal potential of ginger

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