Anti-inflammatory and anticancer compounds isolated from Ventilago madraspatana Gaertn., Rubia cordifolia Linn. and Lantana camara Linn.

Ghosh, Somsubhra; Sarma, Madhushree Das; Patra, Amarendra; Hazra, Banasri

doi:10.1111/j.2042-7158.2010.01151.x

Cited by 115 publications

(65 citation statements)

References 43 publications

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“…Ghosh et al (2010) investigated the antiinflammatory activity of oleanonic acid (8) isolated from L. camara L. using the carrageenan-induced rat paw edema model. Oleanonic acid caused a reduction in edema, which validated its in vivo antiinflammatory effect.…”

Section: Antiinflammatory Analgesic Sedative and Antipyretic Activitymentioning

confidence: 99%

Genus Lantana: chemical aspects and biological activities

Sousa¹,

Costa²

2012

Rev. bras. farmacogn.

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Species of the genus Lantana, belonging to the family Verbenaceae, is among the various species studied scientifically. These species are mainly native to the tropical and subtropical regions of the Americas. Currently, they are present in various countries, where they are often grown as ornamental plants. For decades, species of Lantana have been of great interest for phytochemical, biological and pharmacological studies, which have been recently intensified. The components isolated from different species of Lantana cited in the literature constitute the focus of this review. Information ethnopharmacology of Lantana, as well as the activities of their different phytochemicals are discussed. In this review, it was observed that the genus Lantana has been widely studied in relation to its phytochemical components and terpenoids, flavonoids and phenylpropanoids are the more common secondary metabolites in Lantana. All these aspects, considered in this review, allow an evaluation of the ethnopharmacological potential of Lantana for the utilization of the large biomass of these plants.

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Section: Antiinflammatory Analgesic Sedative and Antipyretic Activitymentioning

confidence: 99%

Genus Lantana: chemical aspects and biological activities

Sousa¹,

Costa²

2012

Rev. bras. farmacogn.

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“…In the phytopharmacological investigation of the plant Lantana camara which has been found to have anti-filarial efficacy, oleanonic acid isolated from hexane and chloroform fractions displayed LC100 at 31.25 µg/ml adult Brugia malayi in vitro [17]. Oleanonic acid has also been isolated from the medicinal plant Lantana camara Linn [18][19] and has been found to inhibit nitric oxide via suppression of the inducible nitric oxide protein with macrophage viability unaffected [18]. It also had anticancer potential by its due to cytotoxic action against the human cancer cell line, A375 (malignant skin melanoma) [18].…”

Section: Discussionmentioning

confidence: 99%

“…Oleanonic acid has also been isolated from the medicinal plant Lantana camara Linn [18][19] and has been found to inhibit nitric oxide via suppression of the inducible nitric oxide protein with macrophage viability unaffected [18]. It also had anticancer potential by its due to cytotoxic action against the human cancer cell line, A375 (malignant skin melanoma) [18]. Furthermore, oleanonic acid isolated from the roots of roots of Scrophularia ningpoensis Hemsl, a Chinese medicinal plant exhibited cytotoxicity against human cancer cell lines such as MCF7, K562, T24S and A549 [19].…”

Section: Discussionmentioning

confidence: 99%

The Hypoglycaemic Effect of Oleanonic Acid Isolated From Pilea Elizabethae in a Rat Model

Lindo

Salmon

McGrowder

2017

Int J Curr Pharm Sci

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Objective: The objective of this study is to isolate and identify the chief hypoglycaemic component of Pilea elizabethae Methods:The chief hypoglycaemic component of Pilea elizabethae was isolated and identified. The bio-directed purification of the chief hypoglycaemic agents contained in Pilea elizabethae followed a sequence of steps alternating oral glucose tolerance test (OGTT) bioassay and chromatographic methods. The ethyl acetate crude extract which was most hypoglycaemic in activity was flash chromatographed on silica gel using a gradient hexane-ethyl acetate solvent system of increasing polarity. Elucidation of the chemical structures of R-E2Gii was determined using NMR and FT-IR spectroscopy, melting point determination and comparison with the literature. The Pilea elizabethae extracts were tested for hypoglycaemic activity in Sprague-Dawley albino rats using the oral glucose tolerance test (OGTT) method. Isolated hypoglycaemic compounds obtained after bio-directed purification were identified through nuclear magnetic resonance (NMR) spectroscopy and infra-red (IR) spectroscopy.Results: Bio-directed purification of Pilea elizabethae extracts yielded a hypoglycemic principle that were coded R-E2Gii. By comparison of its NMR chemical shift values and physical properties with literature values, R-E2Gii found to be the triterpenoid oleanonic acid [C30H40O3; M. W=124]. Conclusion:Bio-directed purification of the hexane-ethyl acetate extracts and using nuclear magnetic resonance (NMR) spectroscopy and infra-red (IR) spectroscopy revealed oleanonic acid, that may be responsible for the anti-hyperglycemic properties of this extract.The isolate R-E2Gii demonstrated significant hypoglycaemic activity. When administered intravenously, values were as low as 4.87±0.09 mmol/l thirty minutes post-load compared with 5.63±0.19 mmol/l for the control (p<0.006). An increase in dosage up to 10 mg/kg body weight amplified the post-prandial hypoglycaemic effect of R-E2Gii. Comparison of the hypoglycaemic effect of R-E2Gii with glibenclamide showed that the isolate was only mildly effective in reducing post-prandial hyperglycaemia. Hexane-ethyl acetate extracts from Pilea elizabethae was found to possess antihyperglycaemic activity on OGTT.

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“…Salvia officinalis contain anti-oxidants and are reported to exert anticancer effects [90]. Lantana camara is traditionally used as folk medicine owing to its antipyretic, antimicrobial and antimutagenic properties and may be anti-carcinogenic [91]. Solanum nigrum, a folk medicine may be used in the treatment of cancer [92].…”

Section: Modern Therapy Vs Herbal Therapymentioning

confidence: 99%

Need of an Ancient Roots to Modern Medicine in the Treatment of Cancer- A review

Gunjan

Naidu²,

Marzo³

et al. 2017

ijpm

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A b s t r a c tThe already available expensive conventional therapies for cancer like chemotherapy and radiotherapy have a number of side effects such as myelosuppression and neurological, cardiac, pulmonary, and renal toxicity, which pose serious harm to the quality of there is a need to develop treatment options that include more potent and less toxic anticancer drugs as compared to existing drugs. and vegetables because of phytochemical compounds ex activity of antioxidant and free radicals which in turn showing anti semi agents are primarily used in com treatment of a variety of cancers. VLB is used for the treatment of leukaemia, lymphomas, advanced testicular cancer, breast and lung cancers, and Kaposi's sarcoma, and VCR, in addition to the treat acute lymphocytic leukaemia in childhood. VRLB has shown activity against non lung cancer and advanced breast cancer. based, natural process in order to stop the growth of cancer cells. This approach can limit the damage to normal cells and the accompanying side effects caused by conventional chemot agents. drug development. The current findings and known anticancer agents from natural sources are discussed, and recent therapeutic advances in this field

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Anti-inflammatory and anticancer compounds isolated from Ventilago madraspatana Gaertn., Rubia cordifolia Linn. and Lantana camara Linn.

Abstract: Ethnomedical reports on these traditional medicinal plants have been rationalised through an insight into the anti-inflammatory as well as anticancer potential of four constituents, characterised to be prospective candidates for designing novel therapeutic agents.

Cited by 115 publications

References 43 publications

Genus Lantana: chemical aspects and biological activities

Genus Lantana: chemical aspects and biological activities

The Hypoglycaemic Effect of Oleanonic Acid Isolated From Pilea Elizabethae in a Rat Model

Need of an Ancient Roots to Modern Medicine in the Treatment of Cancer- A review

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