Anti-inflammatory and antipyretic effects of Sonchus oleraceus in rats

Vilela, Fabiana C.; Bitencourt, Andressa D.; Cabral, Layla D.M.; Franqui, Lidiane S.; Soncini, Roseli; Giusti‐Paiva, Alexandre

doi:10.1016/j.jep.2009.11.030

Cited by 51 publications

(33 citation statements)

References 22 publications

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“…In agreement with previous studies, LPS-induced peritonitis was followed by a significant increase in the number of leukocytes in the peritoneal cavity of mice when compared to the control group treated only with the vehicle (Vilela et al, 2010). The PvHE (30-300 mg/ kg) significantly inhibited (F 5,35 =8.29; p<0.001; Figure 2) leukocyte recruitment induced by LPS (100 μg/kg) into the peritoneal cavity in mice at doses of 30-300 mg/kg.…”

Section: Peritonitis Induced By Lipopolysaccharidesupporting

confidence: 92%

“…All experiments were conducted according to Brazilian Regulations for animal experimentation (COBEA), after approval by the Ethical Commission of Animal Experimentation at the Federal University of Alfenas (#269/2009). The doses used in the present study were selected based on previous studies (de Vilela et al, 2010).…”

Section: Animalsmentioning

confidence: 99%

“…The abdomens were gently massaged and the blood-free cell suspension was carefully aspirated with a syringe. Abdominal washings were placed into plastic tubes, and total cell counts were performed in a Neubauer chamber (Cunha et al, 1989;Vilela et al, 2010).…”

Section: Peritonitis Induced By Lipopolysaccharidementioning

confidence: 99%

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Anti-inflammatory and antinociceptive effects of the hydroethanolic extract of the flowers of Pyrostegia venusta in mice

Veloso¹,

Cabral²,

Bitencourt³

et al. 2012

Rev. bras. farmacogn.

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Pyrostegia venusta (Ker Gawl.) Miers, Bignoniaceae, is native to the Brazilian Cerrado and popularly known as "cipó-de-são-joão". In Brazilian folk medicine, the flowers of P. venusta are used as a general tonic and a treatment for diarrhea, vitiligo, cough, and common infections and inflammatory diseases of the respiratory system. Nevertheless, there are still no studies on its possible anti-inflammatory and antinociceptive effects. The P. venusta hydroethanolic extract (PvHE) was used to evaluate the anti-inflammatory and analgesic effects in carrageenan-induced paw edema, peritonitis induced by lipopolysaccharide, acetic acid-induced writhing, and formalin-induced paw-licking tests in Swiss male mice. PvHE at doses of 30-300 mg/kg p.o. demonstrated anti-inflammatory effect. PvHE reduced paw edema induced by carrageenan and inhibited leukocyte recruitment into the peritoneal cavity. The extracts showed antinociceptive activity in acetic acid-induced writhing and formalin tests. Our results showed that the PvHE demonstrated anti-inflammatory and antinociceptive action in mice. All the anti-inflammatory actions obtained are also suggested to due the presence of acacetin-7-O-β-glucopyranoside.

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Section: Peritonitis Induced By Lipopolysaccharidesupporting

confidence: 92%

Section: Animalsmentioning

confidence: 99%

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Anti-inflammatory and antinociceptive effects of the hydroethanolic extract of the flowers of Pyrostegia venusta in mice

Veloso¹,

Cabral²,

Bitencourt³

et al. 2012

Rev. bras. farmacogn.

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“…Lavandula pubecens is an aromatic folk medicinal plant of repute in Saudi Arabia and Yemen [12,13]. Sonchus oleraceus is known worldwide for its folk medicinal properties including uses as antimalarial, for headaches and general pain-relief [14]. In fact a number of biological activities have been proven for the plant including anti-inflammatory and antipyretic effects in rats [14], antimalaial potential [15], antioxidant activity [16] and anxiolytic-like effects on mice [17].…”

mentioning

confidence: 99%

“…Sonchus oleraceus is known worldwide for its folk medicinal properties including uses as antimalarial, for headaches and general pain-relief [14]. In fact a number of biological activities have been proven for the plant including anti-inflammatory and antipyretic effects in rats [14], antimalaial potential [15], antioxidant activity [16] and anxiolytic-like effects on mice [17]. Aqueous and alcoholic root extracts of Verbesina encelioides, a folk medicinal plant used to treat diabetes, were reported to lower blood sugar levels in mice [18].…”

mentioning

confidence: 99%

Anticancer and Antifolate Activities of Extracts of Six Saudi Arabian Wild Plants Used in Folk Medicine

Albalawi¹,

Bashir²,

Tawfik³

2015

JLS

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Six indigenous folk medicinal plants growing wild in the area of Tabuk, Saudi Arabia which were selected for the study of their phytochemistry as well as their biological activities as antitumor and antifolate agents. Antitumor activities of methanol extracts of the six plants were measured in vitro using three human tumor cell lines (breast, lung and CNS cancers) while antifolate activities were assessed using commercial dihyrofolate reductase obtained from Sigma Co. Among the six plant extracts tested, the most remarkable were those of Caralluma sinaica and Fagonia tenuifolia. Caralluma extract showed strong antitumor activity (low GI 50 ) against the three human tumor cell lines. Fagonia extract, on the other hand, was quite inhibitory to the growth of CNS cancer and breast cancer cell lines but much less so against lung cancer cells. Extracts of both Sonchus oleraceus and Caralluma sinaica were strongly inhibitory to DHFR. These results suggest that the mechanism of anticancer activity of Caralluma plant is through DHFR inhibition but that of Fagonia may follow a different path.

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Antipyretic Agents from Plant Origins

Adedokun,

Imodoye,

Busari

et al. 2023

Phytochemical Drug Discovery for Central Nervous System Disorders

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Anti-inflammatory and antipyretic effects of Sonchus oleraceus in rats

Abstract: The hydroethanolic extract of Sonchus oleraceus markedly demonstrated anti-inflammatory action in rats, which supports previous claims of its traditional use.

Cited by 51 publications

References 22 publications

Anti-inflammatory and antinociceptive effects of the hydroethanolic extract of the flowers of Pyrostegia venusta in mice

Anti-inflammatory and antinociceptive effects of the hydroethanolic extract of the flowers of Pyrostegia venusta in mice

Anticancer and Antifolate Activities of Extracts of Six Saudi Arabian Wild Plants Used in Folk Medicine

Antipyretic Agents from Plant Origins

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