Anti-inflammatory, Antioxidant and Antimicrobial Effects of Artemisinin Extracts from<i>Artemisia annua</i>L.

Kim, Wan-Su; Choi, Woo Jin; Lee, Sunwoo; Kim, Woo Joong; Lee, Dong Chae; Sohn, Uy Dong; Shin, Hyoung-Shik; Kim, Wonyong

doi:10.4196/kjpp.2015.19.1.21

Cited by 126 publications

(84 citation statements)

References 39 publications

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“…The main ingredients of the essential oil of A. annua are beta‐pinene, alpha‐pinene, camphor, camphene, 1,8‐cineole, artemisia ketone, myrcene, borneol, linalool, and beta‐caryophyllene . The pharmacological effects of A. annua include its antimalarial, antioxidant, anti‐inflammatory, antimicrobial, immunomodulatory, and anticancer properties. A variety of compounds have been isolated from A. annua such as coumarins, flavonoids, sesquiterpenoids, triterpenoids, phenolics, and artemisinin…”

Section: Resultsmentioning

confidence: 99%

Medicinal plants in traumatic brain injury: Neuroprotective mechanisms revisited

et al. 2019

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Traumatic brain injury (TBI) is the most prevalent health problem affecting all age groups, and leads to many secondary problems in other organs especially kidneys, gastrointestinal tract, and heart function. In this review, the search terms were TBI, fluid percussion injury, cold injury, weight drop impact acceleration injury, lateral fluid percussion, cortical impact injury, and blast injury. Studies with Actaea racemosa, Artemisia annua, Aframomum melegueta, Carthamus tinctorius, Cinnamomum zeylanicum, Crocus sativus, Cnidium monnieri, Curcuma longa, Gastrodia elata, Malva sylvestris, Da Chuanxiong Formula, Erigeron breviscapus, Panax ginseng, Salvia tomentosa, Satureja khuzistanica, Nigella sativa, Drynaria fortune, Dracaena cochinchinensis, Polygonum cuspidatum, Rosmarinus officinalis, Rheum tanguticum, Centella asiatica, and Curcuma zedoaria show a significant decrease in neuronal injury by different mechanisms such as increasing superoxide dismutase and catalase activities, suppressing nuclear factor kappa B (NF‐κB), interleukin 1 (IL‐1), glial fibrillary acidic protein, and IL‐6 expression. The aim of this study was to evaluate the neuroprotective effects of medicinal plants in central nervous system pathologies by reviewing the available literature.

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Section: Resultsmentioning

confidence: 99%

Medicinal plants in traumatic brain injury: Neuroprotective mechanisms revisited

et al. 2019

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“…; Kim et al . , ). Furthermore, flavonoids isolated from A. annua leaves are known active anti‐malarial and anti‐cancer agents, through the action of artemisinin (Weathers et al .…”

Section: Introductionmentioning

confidence: 99%

Comparative transcriptomic analysis of key genes involved in flavonoid biosynthetic pathway and identification of a flavonol synthase from Artemisia annua L.

Liu

Tang

et al. 2017

Plant Biol J

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The regulatory mechanism of flavonoids, which synergise anti-malarial and anti-cancer compounds in Artemisia annua, is still unclear. In this study, an anthocyanidin-accumulating mutant callus was induced from A. annua and comparative transcriptomic analysis of wild-type and mutant calli performed, based on the next-generation Illumina/Solexa sequencing platform and de novo assembly. A total of 82,393 unigenes were obtained and 34,764 unigenes were annotated in the public database. Among these, 87 unigenes were assigned to 14 structural genes involved in the flavonoid biosynthetic pathway and 37 unigenes were assigned to 17 structural genes related to metabolism of flavonoids. More than 30 unigenes were assigned to regulatory genes, including R2R3-MYB, bHLH and WD40, which might regulate flavonoid biosynthesis. A further 29 unigenes encoding flavonoid biosynthetic enzymes or transcription factors were up-regulated in the mutant, while 19 unigenes were down-regulated, compared with the wild type. Expression levels of nine genes involved in the flavonoid pathway were compared using semi-quantitative RT-PCR, and results were consistent with comparative transcriptomic analysis. Finally, a putative flavonol synthase gene (AaFLS1) was identified from enzyme assay in vitro and in vivo through heterogeneous expression, and confirmed comparative transcriptomic analysis of wild-type and mutant callus. The present work has provided important target genes for the regulation of flavonoid biosynthesis in A. annua.

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“…polymorphum , and Prevotella intermedia . Polyphenol‐containing extracts exhibit antimicrobial activities on Actinobacillus actinomycetemcomitans (Kim et al, ). The result confirms a previous study that reported that artemisinin‐containing water solution extracts had antimicrobial activity against A. actinomycetemcomitans .…”

Section: Pharmacological Properties Of Artemisininmentioning

confidence: 99%

“…Therefore, the artemisinin and hemin combination might have a synergetic antiviral activity. (Kim et al, 2015).…”

Section: Antiviral Effectmentioning

confidence: 99%

More insights into the pharmacological effects of artemisinin

Zyad

Tilaoui

Jaafari

et al. 2017

Phytotherapy Research

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Artemisinin is one of the most widely prescribed drugs against malaria and has recently received increased attention because of its other potential biological effects. The aim of this review is to summarize recent discoveries of the pharmaceutical effects of artemisinin in basic science along with its mechanistic action, as well as the intriguing results of recent clinical studies, with a focus on its antitumor activity. Scientific evidence indicates that artemisinin exerts its biological activity by generating reactive oxygen species that damage the DNA, mitochondrial depolarization, and cell death. In the present article review, scientific evidence suggests that artemisinin is a potential therapeutic agent for various diseases. Thus, this review is expected to encourage interested scientists to conduct further preclinical and clinical studies to evaluate these biological activities.

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Anti-inflammatory, Antioxidant and Antimicrobial Effects of Artemisinin Extracts fromArtemisia annuaL.

Cited by 126 publications

References 39 publications

Medicinal plants in traumatic brain injury: Neuroprotective mechanisms revisited

Medicinal plants in traumatic brain injury: Neuroprotective mechanisms revisited

Comparative transcriptomic analysis of key genes involved in flavonoid biosynthetic pathway and identification of a flavonol synthase from Artemisia annua L.

More insights into the pharmacological effects of artemisinin

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