Anti-inflammatory Constituent from the Root of Rhaphiostylis beninensis(Icacinaceae)

Ofeimun, Josephine; Ayinde, Buniyamin A; Igbe, Ighodaro; Aderogba, M.A.; Adhikari, Achyut; Amjad, H.; Iqbal, M.C.

doi:10.3923/rjphyto.2014.127.132

Cited by 5 publications

(3 citation statements)

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“…Established antioxidant compounds such as Genkwanin, Apigenin, Thioflavin, Quercetagetin, and others may have been responsible for the reported hepatoprotective activity of R. beninensis by Evuen et al 6 . Moreover, the reported estrogenic and anti-inflammatory activity of the spice further affirms the reported aphrodisiac and anti-inflammatory properties of the plant by Ofeimum and Ayinde 12 and Ofeimum et al 5…”

Section: Proximate Composition Of the Spices Findings On The Nutritio...supporting

confidence: 80%

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Evaluation of the mineral composition, phytochemical and proximate constituents of three culinary spices in Nigeria: a comparative study

Evuen

Okolie

Apiamu

2022

Sci Rep

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Spices are prolific sources of phytochemicals of pharmaceutical and nutritional importance. They have been employed for centuries in the treatment of various maladies, in cuisines, and as inhibitors of oxidative degradation in foods. On this premise, a comparative assessment of the quantitative mineral composition, phytochemical and proximate constituents of Xylopia aethiopica (fruits), Piper guineense (seeds), and Rhaphiostylis beninensis (roots) was done using standard protocols. Subsequently, methanol extracts of the spices were subjected to Gas Chromatography–Mass Spectrometry (GC–MS) analysis. Mineral analysis of the culinary spices revealed significant differences (p < 0.05) in the spices’ magnesium, zinc, iron, selenium, copper, calcium, manganese, molybdenum, potassium, and sodium contents. In the phytochemical analysis, flavonoids, phenols, and alkaloids (4.04%, 2.92%, 2.23%) predominate in X. aethiopica. Similarly, proximate analysis shows a preponderance of carbohydrates (81.24%) and proteins (4.83%) in R. beninensis and P. guineense respectively. However, values for the selenium (0.25 mg/L), saponin (0.23%), and moisture (0.71%) contents for R. beninensis were the lowest among the three spices. Results from the GC–MS analysis revealed the presence of thirteen, twelve, and thirteen phytoconstituents of X. aethiopica, P. guineense, and R. beninensis respectively. Prominent among them are hydrocarbons, acids, and esters with renowned biological attributes such as antioxidant, antimicrobial and anti-inflammatory. These findings indicate that the spices are notable wellsprings of bioactive components and justify their plethoric applications in Nigeria. Therefore, they could serve as lead compounds in the search for natural ingredients for drugs and nutraceuticals formulation.

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Section: Proximate Composition Of the Spices Findings On The Nutritio...supporting

confidence: 80%

“…The plant is called atapata (Yoruba), osumadin (Benin), kpolokoto (Igbo), umeni (Urhobo) and kumeni (Itsekiri) 4 . Some biological and pharmacological reports have also been made on the root bark extracts of R. beninensis 5,6 . Piper guineense is a West African spice plant commonly called Ashanti pepper.…”

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confidence: 99%

Evaluation of the mineral composition, phytochemical and proximate constituents of three culinary spices in Nigeria: a comparative study

Evuen

Okolie

Apiamu

2022

Sci Rep

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“… Raphiostylis beninensis Hook F. ex Planch (Metteniusaceae) Leaves and root Crushed leaves and twigs are applied on glandular swellings. Kpolokoto Agbegi village, Ikire, Osun state Latitude: 7° 21′ 36.00″ N Longitude: 4° 11′ 6.00″ E. FHI 113105 [ 10 , 26 , 27 ] 7. Ritchiea capparoides Andr.…”

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confidence: 99%

Antiproliferative activities of some selected Nigerian medicinal plants against breast, liver, and cervical cancer cells

Olaleye,

Kim,

Spriggs

2024

BMC Complement Med Ther

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Background Phytochemicals have become a growing source of alternative medicine in developing countries due to the poor prognosis, high cost of conventional pharmaceuticals, and undesirable effects associated with mainstream cancer treatment. Objective This study was aimed at investigating the anticancer effect of some selected Nigerian medicinal plants used in cancer treatment. These include ethanol extracts of Dialium guineense root (DGR), Dialium guineense leaves (DGL), Jateorhiza macrantha leaves (JML), Musanga cecropioides leaves (MCL), Musanga cecropioides stembark (MCSB), Piptadeniastrum africanum stembark (PASB), Piptadeniastrum africanum root (PAR), Pupalia lappacea flower tops (PLF), Raphiostylis beninensis root (RBR), Raphiostylis beninensis leaves (RBL), Ritchiea capparoides leaves (RCL), Ritchiea capparoides stembark (RCSB), and Triplochiton scleroxylon stembark (TSB). Methods The cytotoxic activity of the extracts was examined using a brine shrimp lethality assay and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay against three cancer cell lines, including MCF-7, HUH-7, and HeLa. The selectivity of all extracts towards cancer cells was investigated using normal lung fibroblasts (MRC-5). Cell migration and colony-forming assays of active extracts against MCF-7 cells were also performed. Additionally, the total polyphenolic contents of the active extracts were estimated using standard methods. Results The extract of PASB had the highest cytotoxicity (LC50 = 1.58 μg/mL) on the brine shrimps compared to vincristine sulphate (LC50 = 2.24 μg/mL). In the cell viability assay, all the extracts produced significant (p < 0.05) growth inhibitory effects against all cell lines tested in a dose-dependent manner. All extracts were selective to cancer cells at varying degrees. Worth mentioning are the extracts of MCL, DGR, RBR, and PASB, which exhibited 14-, 7-, 6- and 2-fold selectivity toward MCF-7 cancer cells relative to normal lung fibroblast (MRC-5), respectively. These four extracts also significantly inhibited cell migration and colony formation in MCF-7-treated cells in dose-dependent manners. Considerable amounts of phenolics, flavonoids, and proanthocyanidins were detected in all extracts evaluated. Conclusion These findings advocate the continued development of MCL, DGR, RBR, and PASB as potential chemotherapeutic agents.

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Photocatalytic degradation of phenazopyridine contaminant in soil with direct solar light

Zyoud

Ateeq

Helal

et al. 2018

Environmental Technology

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Photocatalytic degradation of waste pharmaceutics, with solar radiation, is described here as a feasible method to purify pre-contaminated soils. Phenazopyridine has been used as a model soil contaminant. Two different nano-size powders have been first examined as catalysts, namely commercial TiO (anatase) and commercial ZnO. As the ZnO showed higher catalytic efficiency, the study was then focused on it. The commercial ZnO powder was then compared with lab-prepared ZnO powder, and the latter shows relatively higher efficiency. The ZnO was used in two different ways. In one way, dry ZnO catalyst powder was spread onto the soil, while in the other way the ZnO was sprayed onto the soil surface by a wet spray method. The spray technique shows slightly higher efficiency, in addition to being easier to apply at future large scale. Depending on conditions and type of photocatalyst used, up to 90% contaminant removal can be achieved in 30 min. In case of photocatalysis experiments, the reacted contaminant molecules undergo complete degradation with no detectable side reaction organic products. Possible evaporation or escape of organic contaminant, or other possibly resulting organics, is ruled out by a series of control experiments. Photodegradation process takes place only at the catalytic sites on the soil surface, where contaminant molecules that diffuse from the soil bulk are completely degraded. Other useful organisms inside the soil are not affected as they are kept away from catalyst sites. A plausible mechanism is proposed for the degradation process.

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Anti-inflammatory Constituent from the Root of Rhaphiostylis beninensis(Icacinaceae)

Cited by 5 publications

References 2 publications

Evaluation of the mineral composition, phytochemical and proximate constituents of three culinary spices in Nigeria: a comparative study

Evaluation of the mineral composition, phytochemical and proximate constituents of three culinary spices in Nigeria: a comparative study

Antiproliferative activities of some selected Nigerian medicinal plants against breast, liver, and cervical cancer cells

Photocatalytic degradation of phenazopyridine contaminant in soil with direct solar light

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