One of the modern trends in the study of the protective barrier of the skin is the study of the dynamics of the skin process. As a result of the active inflammatory process, a decrease in moisture levels occurs, a violation of the hydrolipid mantle of the skin and a decrease in natural moisturizing factors. The formation and maintenance of a protective skin barrier is an important pathogenetic tool in the treatment of inflammatory dermatoses. Chronic dermatoses often require regular topical therapy, so safe, convenient and effective topical regimens with good cosmetic properties can be very beneficial for this group of patients. Moisturizing and barrier-restoring formulations are clinically recognized as valuable topical treatments for patients with chronic dermatoses.