Anti-inflammatory effects of 1,8-cineole (eucalyptol) improve glucocorticoid effects in vitro: A novel approach of steroid-sparing add-on therapy for COPD and asthma?

New Perspectives for Mucolytic, Anti-inflammatory and Adjunctive Therapy with 1,8-Cineole in COPD and Asthma: Review on the New Therapeutic Approach

“…Inflammatory processes, particularly in COPD, are characterized by only partial therapy responses to ICS, depending on the type of inflammation, such as the COPD-bronchitis type with exposure to CS, inhaled ROS and/or by increased production of exacerbation activated airway cells or the degree and mixture with neutrophilic/eosinophilic Th1/Th2-type inflammation in asthma and ACO. As previously shown [40,52] in vitro, anti-inflammatory and antioxidant effects increased additively by co-incubation of 1,8-cineole ? ICS or 1,8cineole ?…”

Chemical composition and antibacterial activity of the essential oil of Myrtus communis leaves

“…The difference observed in the sensitivity of different microorganisms is essentially due to their chemical composition, especially the presence of monoterpenes [60] such as eucalyptol (1,8-cineole) and a-pinene. These compounds belong to the ether and hydrocarbon groups [61], and they are well known for their antimicrobial properties [62]. Indeed Eucalyptol is a natural saturated monoterpene, which has been used for the symptomatic treatment of sinusitis and bronchitis due to its mucolytic, antimicrobial and spasmolytic properties [62].…”

“…These compounds belong to the ether and hydrocarbon groups [61], and they are well known for their antimicrobial properties [62]. Indeed Eucalyptol is a natural saturated monoterpene, which has been used for the symptomatic treatment of sinusitis and bronchitis due to its mucolytic, antimicrobial and spasmolytic properties [62]. And it is not forgotten that probably the synergistic effect between all components of the essential oil of M. communis may be attributed to the antimicrobial activity of the essential oil.…”

Current Developments on Anti-Inflammatory Natural Medicines

“…1,8-cineole has anti-inflammatory properties and based on this properties, recent clinical trials have shown the beneficial use of 1,8-cineole as long-term therapy in the prevention of chronic obstructive pulmonary diseases (COPD)-exacerbations and to improve asthma control [30,31]. As non-steroidal anti-inflammatory agent, 1,8-cineole can improve steroid effects when combined with budesonide and formoterol for asthma and COPD [32]. 1,8-cineole reduced lipopolysaccharide (LPS)-induced inflammation by inhibiting NF-κB in human cell lines U373 and HeLa [33].…”