Anti-inflammatory Effects Of Budesonide In Human Lung Fibroblasts Are Independent Of HDAC2

Pharmacotherapy of chronic obstructive pulmonary disease: Therapeutic considerations with a focus on inhaled corticosteroids

“…10 It was subsequently found that certain anti-inflammatory effects of steroids are independent of HDAC2. 11 Thus, this pathway can be bypassed for ICS to ameliorate tissue damage. A meta-analysis of studies that evaluated inflammatory biomarkers in sputum, bronchoalveolar lavage fluid and biopsy specimens demonstrated that ICS led to a reduction in cluster of differentiation 4 (CD4+), CD8+, neutrophils and lymphocytes.…”