Anti-Inflammatory Function of Plant-Derived Bioactive Peptides: A Review

Liu, Wanlu; Chen, Xinwei; Li, He; Zhang, Jian; An, Jiulong; Liu, Xinqi

doi:10.3390/foods11152361

Cited by 53 publications

(31 citation statements)

References 82 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Studies have proven the safety of CPs. They also have various functions, such as antioxidant, anti-inflammatory, anti-hypertensive, immune boosting, and anti-fatigue [ 4 , 17 ]. Some researchers have found a protective effect of CPs against early alcoholic liver injury in mice and rats [ 33 , 34 ].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

The Protective Effects of Corn Oligopeptides on Acute Alcoholic Liver Disease by Inhibiting the Activation of Kupffer Cells NF-κB/AMPK Signal Pathway

Wei

Feng

et al. 2022

Nutrients

View full text Add to dashboard Cite

Alcohol can cause injury and lead to an inflammatory response in the liver. The NF-κB/AMPK signaling pathway plays a vital role in regulating intracellular inflammatory cytokine levels. In this study, corn oligopeptides (CPs), as the research objects, were obtained from corn gluten meal, and their regulation of the activation of the Kupffer cell NF-κB/AMPK signal pathway induced by LPS was investigated. Results showed that ALT, AST, and inflammatory cytokines in mice serum after the administration of CPs at 0.2, 0.4, and 0.8 g/kg of body weight displayed a distinct (p < 0.05) reduction. On the other hand, the CPs also inhibited the expression of recognized receptor CD14 and TLR4, down-regulated P-JNK, P-ERK, and P-p-38, and thus inhibited inflammatory cytokine levels in Kupffer cells (KCs). Furthermore, four kinds of dipeptides with a leucine residue at the C-terminus that might exhibit down-regulated inflammatory cytokines in the NF-κB/AMPK signaling pathway functions were detected using HPLC-MS/MS. These results indicated that CPs have a potential application value in acute alcoholic liver disease.

show abstract

Section: Discussionmentioning

confidence: 99%

“…Thus, the ALD-protective ingredients extracted from plants and animals have attracted attention from researchers in academia and industry. Numerous studies have confirmed that food-derived oligopeptides can be used as potential dietary therapeutics and new functional raw materials for enhancing health [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

The Protective Effects of Corn Oligopeptides on Acute Alcoholic Liver Disease by Inhibiting the Activation of Kupffer Cells NF-κB/AMPK Signal Pathway

Wei

Feng

et al. 2022

Nutrients

View full text Add to dashboard Cite

show abstract

“…Inflammation is how the body restores itself after injury, replaces damaged tissue and combats pathogens [ 195 ]. Inflammation may be acute or chronic.…”

Section: Biopeptides’ Potential In Cosmeceutical Applicationsmentioning

confidence: 99%

“…Low molecular weight peptides can reach their target place intact (they have few cleavage sites for endopeptidase enzymes) and have specific transport modes. Peptide transport modes include PepT1 transporters, cytokinesis, cellular bypass, and passive diffusion; dipeptides and tripeptides can also be in the PepT1 category [ 195 ]. Regardless of amino acid composition, highly hydrophobic biopeptides containing leucine, tryptophan, and phenylalanine have anti-inflammatory potential.…”

Section: Biopeptides’ Potential In Cosmeceutical Applicationsmentioning

confidence: 99%

See 1 more Smart Citation

Food Peptides for the Nutricosmetic Industry

Dini

Mancusi

2023

Antioxidants

View full text Add to dashboard Cite

In recent years, numerous reports have described bioactive peptides (biopeptides)/hydrolysates produced from various food sources. Biopeptides are considered interesting for industrial application since they show numerous functional properties (e.g., anti-aging, antioxidant, anti-inflammatory, and antimicrobial properties) and technological properties (e.g., solubility, emulsifying, and foaming). Moreover, they have fewer side effects than synthetic drugs. Nevertheless, some challenges must be overcome before their administration via the oral route. The gastric, pancreatic, and small intestinal enzymes and acidic stomach conditions can affect their bioavailability and the levels that can reach the site of action. Some delivery systems have been studied to avoid these problems (e.g., microemulsions, liposomes, solid lipid particles). This paper summarizes the results of studies conducted on biopeptides isolated from plants, marine organisms, animals, and biowaste by-products, discusses their potential application in the nutricosmetic industry, and considers potential delivery systems that could maintain their bioactivity. Our results show that food peptides are environmentally sustainable products that can be used as antioxidant, antimicrobial, anti-aging, and anti-inflammatory agents in nutricosmetic formulations. Biopeptide production from biowaste requires expertise in analytical procedures and good manufacturing practice. It is hoped that new analytical procedures can be developed to simplify large-scale production and that the authorities adopt and regulate use of appropriate testing standards to guarantee the population’s safety.

show abstract

Molecular insights into the anti‐inflammatory activity of fermented pineapple juice using multimodal computational studies

Tallei,

Fatimawali,

Adam

et al. 2023

Archiv der Pharmazie

View full text Add to dashboard Cite

Pineapple has been recognized for its potential to enhance health and well‐being. This study aimed to gain molecular insights into the anti‐inflammatory properties of fermented pineapple juice using multimodal computational studies. In this study, pineapple juice was fermented using Lactobacillus paracasei, and the solution underwent liquid chromatography‐mass spectrometry analysis. Network pharmacology was applied to investigate compound interactions and targets. In silico methods assessed compound bioactivities. Protein–protein interactions, network topology, and enrichment analysis identified key compounds. Molecular docking explored compound–receptor interactions in inflammation regulation. Molecular dynamics simulations were conducted to confirm the stability of interactions between the identified crucial compounds and their respective receptors. The study revealed several compounds including short‐chain fatty acids, peptides, dihydroxyeicosatrienoic acids, and glycerides that exhibited promising anti‐inflammatory properties. Leucyl–leucyl–norleucine and Leu–Leu–Tyr exhibited robust and stable interactions with mitogen‐activated protein kinase 14 and IκB kinase β, respectively, indicating their potential as promising therapeutic agents for inflammation modulation. This proposition is grounded in the pivotal involvement of these two proteins in inflammatory signaling pathways. These findings provide valuable insights into the anti‐inflammatory potential of these compounds, serving as a foundation for further experimental validation and exploration. Future studies can build upon these results to advance the development of these compounds as effective anti‐inflammatory agents.

show abstract

Anti-Inflammatory Function of Plant-Derived Bioactive Peptides: A Review

Cited by 53 publications

References 82 publications

The Protective Effects of Corn Oligopeptides on Acute Alcoholic Liver Disease by Inhibiting the Activation of Kupffer Cells NF-κB/AMPK Signal Pathway

The Protective Effects of Corn Oligopeptides on Acute Alcoholic Liver Disease by Inhibiting the Activation of Kupffer Cells NF-κB/AMPK Signal Pathway

Food Peptides for the Nutricosmetic Industry

Molecular insights into the anti‐inflammatory activity of fermented pineapple juice using multimodal computational studies

Contact Info

Product

Resources

About