Anti-nociceptive Effect of Caralluma edulis on Peripheral and Central Pain Pathways

Firdoos, Sundas; Khan, Arif-ullah; Ali, Fawad

doi:10.17576/jsm-2017-4610-24

Cited by 4 publications

(2 citation statements)

References 11 publications

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“…[11][12][13] The extracts of C. edulis are reported to have antioxidant, antidiabetic, antinociceptive, antiinflammatory and hunger suppressant effects. [14][15][16][17] The current study was designed to evaluate CE.Cr for its potential against obesity, hypertension, atherosclerosis and oxidative stress, and to provide scientific evidence for its folkloric uses.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Caralluma edulis for its Potential Against Obesity, Atherosclerosis and Hypertension

et al. 2023

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Obesity, a chronic metabolic condition, is an increase in fat mass and blood lipid levels mainly causing atherosclerosis and hypertension, which further lead to cardiovascular complications. The objective of the study was to investigate the crude extract of Caralluma edulis (CE.Cr) for its potential against high-fat diet (HFD)-induced obesity and its related complications. Hyperlipidemia was induced in Wistar albino rats with HFD (1% cholesterol + 0.5% cholic acid) for 28 days. Treatment groups were administered with different doses of CE.Cr (100, 300 and 500 mg/Kg, p.o.) and the standard group received atorvastatin. At the end of study, sera were analyzed for biochemical markers and the aorta was dissected for microscopic examination. Antioxidant potential was evaluated and high-performance liquid chromatography (HPLC) analysis was performed. The hypotensive potential of CE.Cr was evaluated through an invasive technique. HPLC analysis of CE.Cr showed the presence of chlorogenic acid, caffeic acid, apigenin and naringenin. Histological examination of the aorta section showed anti-atherosclerotic effects which were also evident from decrease in serum total cholesterol, triglycerides and low-density lipoproteins levels. CE.Cr decreased mean arterial blood pressure and evoked significant hypotensive effects. The crude extract of C. edulis showed anti-obesity, antihypertensive, anti-atherosclerotic and antioxidant potential.

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Section: Introductionmentioning

confidence: 99%

Evaluation of Caralluma edulis for its Potential Against Obesity, Atherosclerosis and Hypertension

et al. 2023

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“…In multiple ethnobotanical reports, it was found that natives consume it in various forms for the management of diabetes mellitus (Ahmad, Khan, Arshad, & Zafar, 2006;Ahmad, Qureshi, Arshad, Khan, & Zafar, 2009;Malik et al, 2015;Yaseen et al, 2015). The extracts of C. edulis are reported to have antioxidant (Shad, Bakht, Shah, & Hayat, 2016), antidiabetic (Sayantan & Abhishek, 2012), antinociceptive (Firdoos, Khan, & Ali, 2017), antiinflammatory (Minhas, Khan, & Ansari, 2018), antihyperlipidemic (Ashfaq et al, 2017), and hunger suppressant effects (Surveswaran, Cai, Xing, Corke, & Sun, 2010). The chemical composition of C. edulis disclosed β-sitosterol, magasatgmane, glycosides, steroidal glycosides, saturated pregnane steroids, and flavonoids (Abdel-Sattar et al, 2008;Memon & Bhatti, 1984).…”

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Microscopic investigations and pharmacognostic techniques for the standardization ofCaralluma edulis(Edgew.) Benth. ex Hook.f.

et al. 2019

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Herbal medicines frequently suffer with quality controversies because of similar species or varieties. This often leads to sophistication or admixture of the crude drug as they share various look alike physical features. Commercially, stalks of Caralluma edulis are commonly adulterated with other species because of their analogous morphology. In the present research, the microscopic standardization of the drug was performed by structural, histological, and anatomical features. Pharmacognostical characterization was carried out by physicochemical (moisture content, swelling index, pH value, ash values, and extractive values) and fluorescence analysis. The chemical characterization by UV–Visible, Fourier transform infrared spectroscopy, and high‐performance liquid chromatography was also performed that disclosed the chief phytoconstituents of the herbal drug. The above mentioned constraints, being reported for the first time in C. edulis, are substantial in establishing the microscopic and pharmacopoeial standards for future identification and authentication.

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In vitro antioxidant and enzyme inhibitory studies, computational analysis and chemodiversity of an emergency food plant Caralluma edulis (Edgew.) Benth. ex Hook.f: A multifunctional approach to provide new ingredients for nutraceuticals and functional foods

Shazmeen

Nazir²,

Riaz³

et al. 2022

Food Bioscience

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Anti-nociceptive Effect of Caralluma edulis on Peripheral and Central Pain Pathways

Abstract: ABSTRACT

Cited by 4 publications

References 11 publications

Evaluation of Caralluma edulis for its Potential Against Obesity, Atherosclerosis and Hypertension

Evaluation of Caralluma edulis for its Potential Against Obesity, Atherosclerosis and Hypertension

Microscopic investigations and pharmacognostic techniques for the standardization ofCaralluma edulis(Edgew.) Benth. ex Hook.f.

In vitro antioxidant and enzyme inhibitory studies, computational analysis and chemodiversity of an emergency food plant Caralluma edulis (Edgew.) Benth. ex Hook.f: A multifunctional approach to provide new ingredients for nutraceuticals and functional foods

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