Anti‐proliferative and Apoptotic Effects of Coordination Compounds of Zinc(II), Palladium(II), and Platinum(II) with Tridentate 4‐(6‐hydroxyphenyl)‐2,6‐di(thiazol‐2‐yl)pyridine

Abstract

The mononuclear coordination compounds, [Zn(L)Cl2] (1), [Pd(L)Cl]Cl (2), and [Pt(L)Cl]Cl (3) (L) is a tridentate‐coordinated of 4‐(6‐hydroxyphenyl)‐2,6‐di(thiazol‐2‐yl)pyridine) were synthesized and characterized by different spectroscopic methods (FTIR, MALDI‐TOF‐MS, 1H NMR, 13C NMR, and UV/Vis). By using density functional theory (DFT) and time‐dependent DFT (TD‐DFT) methods, the geometrical parameters, UV/Vis absorption spectra, and infrared vibrational frequencies for the investigated compounds were explored. Anticancer activities of these compounds were determined by SRB viability assay in human lung (A549 and H1299), prostate (LNCAP), colorectal (HT‐29), breast cancer (MDA‐MB‐231) and healthy bronchial (BEAS‐2B), breast (MCF‐10A), colon (CCD‐18Co), and prostate (WPMY‐1) epithelial cells. Caspase 3/7 activity, cleaved cytokeratin‐18, and PARP levels were measured to determine apoptosis in the metal compounds found to be effective. Among the compounds, 1 showed a selective inhibiting effect and induced apoptosis on the cancer cells, thus further analyses are needed to evaluate its antitumor/anticancer activity.

A comparative study on the synthesis and crystal structures of Ni(ii) complexes bearing tetradentate N2O2 donor Schiff bases: biomolecular interactions, cytotoxicities and molecular docking

“…The IC 50 values, pivotal in assessing cytotoxicity, have been computed and are documented in Table 6. For ligands 1a–b , higher cytotoxic effects were observed against the MCF-7 cell line, and 1b exhibited higher cytotoxic effects against the H1299 cell line with lower IC 50 values compared with cisplatin, 72–74 indicating their efficiency in killing cancer cells even at low concentrations. Additionally, the cytotoxic potential of ligands 1a–b was determined using the MCF-7 cell line.…”