Anti-vancomycin-resistant Enterococcus faecium and E. faecalis activities of (-)-gossypol and derivatives from Thespesia garckeana

Abstract

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Structure-dependent activity of plant natural products against methicillin-resistant Staphylococcus aureus

“…Compound 22 was isolated from Mentha pulegium and exhibited moderate activity with an IC 50 value of 8.5 μg/mL ( Ibrahim, 2013 ). The dimeric sesquiterpenoid gossypol ( 23 ), which is also known from the cotton plant, was isolated from Thespesia garckeana by Masila et al (2015) and showed an IC 50 of 4.66 μg/mL. Häkkinen et al (2021) tested the germacranolide lactones parthenolide ( 24 , from Tanacetum parthenium ) and lactucopicrin ( 25 , from Cichorium intybus ) against a β-lactamase possessing strain, with pronounced effects (MIC value of 0.16 μg/mL).…”

“…While 82 was only moderately active (with a MIC value of 31.25 μg/mL), the methylated form (83) showed pronounced effects (MIC: 7.81 μg/mL). Zuo et al (2015) isolated two biphenyl compounds, 84 and 85, from Biancaea sappan, which was previously ascribed to the genus Caesalpinia, in a bioactivity-guided isolation procedure. Both compounds showed moderate to low activity but demonstrated synergistic effects in combination with amikacin and gentamycin (Figure 5).…”

“…Seven isoflavanones with widely ranging activities (129-135) were isolated from Erythrina variegata and Erythrina costaricensis by Tanaka et al (2009,2015). While compounds (129, 130, 134, and 135) only showed moderate effects against 13 different MRSA strains, promising activities were observed for compounds 131 to 133.…”

Ameliorative and fecundity potentials of aqueous extract of Azanza garckeana (T. Hoffm) fruit pulp in formalin-induced toxicity on male albino mice

“…It is also used traditionally to enhance libido as its consumption is traditionally claimed to enhance development of a strong desire for sexual intercourse in both males and females alike, suggesting its possible aphrodisiac property. Azanza garckeana has been reported to possess antibacterial and antifungal activities [2][3][4][5], anti-hyperglycemic effect [6], antioxidant and cytotoxicity activity [5,7] and antimalarial property [8]. Some of these pharmacological properties have been attributed to some of the phytochemicals such as tannins, flavonoids, saponins, alkaloids and xanthones that are found in it [3,[9][10][11].…”

“…Azanza garckeana has been reported to possess antibacterial and antifungal activities [2][3][4][5], anti-hyperglycemic effect [6], antioxidant and cytotoxicity activity [5,7] and antimalarial property [8]. Some of these pharmacological properties have been attributed to some of the phytochemicals such as tannins, flavonoids, saponins, alkaloids and xanthones that are found in it [3,[9][10][11].…”