ANTIAGE-DB: A Database and Server for the Prediction of Anti-Aging Compounds Targeting Elastase, Hyaluronidase, and Tyrosinase

Abstract

Natural products bear a multivariate biochemical profile with antioxidant, anti-inflammatory, antibacterial, and antitumoral properties. Along with their natural sources, they have been widely used both as anti-aging and anti-melanogenic agents due to their effective contribution in the elimination of reactive oxygen species (ROS) caused by oxidative stress. Their anti-aging activity is mainly related to their capacity of inhibiting enzymes like Human Neutrophil Elastase (HNE), Hyaluronidase (Hyal) and Tyrosinase (Tyr). Herein, we accumulated literature information (covering the period 1965–2020) on the inhibitory activity of natural products and their natural sources towards these enzymes. To navigate this information, we developed a database and server termed ANTIAGE-DB that allows the prediction of the anti-aging potential of target compounds. The server operates in two axes. First a comparison of compounds by shape similarity can be performed against our curated database of natural products whose inhibitory potential has been established in the literature. In addition, inverse virtual screening can be performed for a chosen molecule against the three targeted enzymes. The server is open access, and a detailed report with the prediction results is emailed to the user. ANTIAGE-DB could enable researchers to explore the chemical space of natural based products, but is not limited to, as anti-aging compounds and can predict their anti-aging potential. ANTIAGE-DB is accessed online.

Characterization and anti-aging effects ofOpuntia ficus-indica(L.) Miller extracts in ad-galactose-induced skin aging model

“…28 Among the identified compounds, free fatty acids were also previously reported to exhibit collagenase and elastase inhibitory activities. 108,109…”

“…28 Among the identified compounds, free fatty acids were also previously reported to exhibit collagenase and elastase inhibitory activities. 108,109 Indicaxanthin was previously reported in OFI peel and pulp, besides other betalain compounds. 82,110,111 In our study, indicaxanthin was the only betalain compound identified.…”

Research Progress of Bioactive Components in Sanghuangporus spp.

“…Early in 2019, Wang et al proved that 200 μg/mL ethanol extracts of I. obliquus showed the best antiaging effect in PC12 cell models among other test samples [ 236 ]. After using S. vaninii methanol and hot water extracts in vitro that mainly contain phenolic and flavonoid components, Li et al reported an antiwrinkle ability based on the inhibiting effect on tyrosinase, the self-oxidation of L-3,4-dihydroxyphenylalanine (L-DOPA), elastase, and collagenase; these are critical molecules in the body and arterial aging [ 162 , 237 , 238 ]. Also, in 2019, Gu et al stated that a Sanghuang decoction consisting of 2 g/mL crude medicine, mostly polysaccharides, triterpenoids, and flavonoids, could initiate the transcription of gene HO-1, thereby inhibiting oxidative stress and delaying the progression of aging [ 181 ].…”

Black Pepper’s Anti-Aging and Chemo-preventive Properties: A Review

“…Antioxidant Activity Antioxidants are chemicals that limit or stop cell oxidation caused by free radicals. [35]. To keep the body functioning at its best, antioxidant supplementation is a growingly common practice [36].…”

“…Free radicals can harm cells, resulting in early aging and several disorders. One effort to capture free radicals is antioxidants such as vitamins C and E ( [35].…”