Antibacterial ability and osteogenic activity of polyphenol-tailored calcium silicate bone cement

Abstract

Calcium silicate-based cement (CSC) has attracted much interest because of its favourable osteogenic effect supporting its clinical use. Despite CSC has antibacterial activity, this activity still needs to be improved...

Synergistic Effect of Thermoresponsive and Photocuring Methacrylated Chitosan-Based Hybrid Hydrogels for Medical Applications

“…Among the three phenolic compounds, the GA-containing hydrogel did not enhance the antibacterial activity against E. coli and S. aureus. This may be because the COOH functional group in GA played a key role in offsetting the NH2 functional of chitosan compared with PG and TA [27]. However, the presence of GA could enhance the antibacterial ability of the methacrylated chitosan-based hybrid hydrogels against P. gingivalis and S. mutans, which should be due to different bacterial strains.…”

“…When three different phenolic compounds were added to 5CMG, there appeared to be subtle differences in the bands despite the addition of small amounts of polyphenols (Figure 7b). The band around 1620 cm −1 was ascribed to the C=C stretching vibration of the aromatic ring [27], and the band at 550 cm −1 was broadened. In addition, 5CMG shifted from the band of 1088 cm −1 to a low wavenumber of 1075 cm −1 , which may be due to the electrostatic and hydrophobic interactions between 5CMG and phenolic compounds.…”

“…The bacteriostatic ratio (%) based on the absorbance of alamarBlue was calculated as follows: (absorbance of negative control-absorbance of samples)/absorbance of negative control × 100%. Three independent experiments were performed [27].…”

“…The emergence of drug resistance urgently requires more effective non-antibiotic alternatives to treat bacterial infections. For this reason, naturally antimicrobial compounds have attracted great attention [26,27]. Natural polyphenols are organic compounds comprised of a phenolic ring bearing carboxyl and hydroxyl groups, which possess antioxidant properties and antimicrobial activities [27].…”

“…For this reason, naturally antimicrobial compounds have attracted great attention [26,27]. Natural polyphenols are organic compounds comprised of a phenolic ring bearing carboxyl and hydroxyl groups, which possess antioxidant properties and antimicrobial activities [27]. Phenolic compounds such as tannic acid and pyrogallol can be loaded or grafted onto the biomaterials to achieve clinical therapy.…”