Antibacterial Activity and Anticancer Activity of Rosmarinus officinalis L. Essential Oil Compared to That of Its Main Components

Wang, Wei; Li, Nan; Luo, Meng; Zu, Yuangang; Efferth, Thomas

doi:10.3390/molecules17032704

Cited by 225 publications

(160 citation statements)

References 19 publications

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“…Our results are in agreement with previous study (Wang et al 2012), which has reported that α-pinene and β-pinene isolated from Rosmarinus officinalis demonstrated strong cytotoxicity towards human ovarian cancer cell lines (SK-OV-3 and HO-8910) and human hepatocellular liver carcinoma cell line (Bel-7402) in the MTT in vitro assay. Also, Matsuo et al (2011) revealed that α-pinene was able to induce apoptosis evidenced by early disruption of the mitochondrial potential, production of reactive oxygen species, and increase in caspase-3 activity in B16F10 murine melanoma cell.…”

Section: Primary Rat Neuronssupporting

confidence: 83%

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Antioxidative, anticancer and genotoxic properties of α-pinene on N2a neuroblastoma cells

2013

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α-Pinene, an organic monoterpene, is found in essential oils of pine and coniferous trees. To date, although various biological activities of α-pinene have been demonstrated, its neurotoxicity has never been explored. Therefore in this study, we aimed to describe in vitro antiproliferative and/or cytotoxic properties by 3-(4,5-dimetylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) test, genotoxic damage potentials by single cell gel electrophoresis, and oxidative effects by total antioxidant capacity (TAC) and total oxidative stress (TOS) analysis of α-pinene. Statistical analysis of MTT assay results indicated significant (p < 0.05) decreases of the cell proliferation rates in healthy neurons treated with α-pinene at only 400 mg/L, while significant decreases were observed in N2a cells at 100, 200 and 400 mg/L. On the other hand, the mean values of the total scores of cells showing DNA damage were not found significantly different from the control values on both cells. In addition, our results indicated that 10 and 25 mg/L of α-pinene treatment caused increases of TAC levels in primary rat neurons without any alterations of its level in N2a cells. However, α-pinene treatments at higher doses led to increases of TOS levels in both cell types. Overall our results suggest that α-pinene is of a limited therapeutic use as an anticancer agent.

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Section: Primary Rat Neuronssupporting

confidence: 83%

“…α-Pinene was reported to have a broad spectrum of biological activities, i.e. antiinflammatory (Bae et al 2012), antibacterial (Dorman et al 2000) antioxidant (Wang et al 2008), anticancer (Wang et al 2012) and antinociceptive (Him et al 2008) activities.…”

Section: Introductionmentioning

confidence: 99%

Antioxidative, anticancer and genotoxic properties of α-pinene on N2a neuroblastoma cells

2013

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“…The antimicrobial activity of C. bejolghota bark oil may be correlated to the diversity of its bioactive compounds. These include 1,8-cineole (comprising 40.24% of the oil) and γ-terpineol (15.41%) in the essential oil, both of which have potent antibacterial and fungicidal activities (Carson et al, 2002;Hendry, Worthington et al, 2009;Wang et al, 2012). Mahboubi and Kazempour, 2009 reported that antibacterial activity of whole essential oil was greater than that obtained from major components alone.…”

Section: Resultsmentioning

confidence: 99%

Chemical composition, antibacterial and antifungal activities of Cinamomum bejolghota bark oil from Thailand

Atiphasaworn¹,

Monggoot²,

Pripdeevech³

2017

J App Pharma Sci

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The volatile constituents of Cinnamomum bejolghota bark essential oil were investigated by using gas chromatography-mass spectrometry (GC-MS). Thirty-six volatile constituents were identified with the major components being 1,8-cineole, γ-terpineol, borneol and terpinen-4-ol. Essential oil of C. bejolghota bark was firstly screened for their antibacterial and antifungal activities against Gram-positive and Gram-negative bacteria, as well as, Colletotrichum sp. fungi using disc diffusion method. Minimal inhibitory concentration (MIC) of C. bejolghota bark oil was further analyzed by microdilution. Essential oil of C. bejolghota bark was most effective against bacteria with MIC ranging from 31.25-62.50 μg/mL, whereas inhibition against fungal pathogens was moderate, with MIC of 125-500 μg/mL. The strong antimicrobial activity of C. bejolghota bark oil was correlated mainly to 1,8-cineole, γ-terpineol, borneol, terpenen-4-ol and linalool.

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“…Segundo Kim et al (1995), alguns tem a capacidade de inibir bactérias de origem alimentar e prolongar a vida de prateleira de alimentos processados. Além disso, estudos apontam que essas substâncias possuem efeito antifúngico (Machado et al, 2013), anti--inflamatórios, antinociceptivo e antiespasmódico (Daniel et al, 2009;Adorjan & Buchbauer, 2010;Pinho et al, 2012), atividades antitumoral (Wang et al, 2012;Quassinti et al, 2013) e inseticida (Lima et al, 2014). Portanto, é necessária a implantação de políticas públicas de conscientização, voltadas para o melhor manejo do extrativismo sustentável desse bioma, com vistas à preservação.…”

Section: Fonte: Adaptado De Sebrae (2007)unclassified

Motivações socioeconômicas para a conservação e exploração sustentável do bioma Caatinga

Maia

Sousa

Lira

et al. 2017

Desenvolv. Meio Ambiente

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Ensaio recebido em 13 de novembro de 2016, versão final aceita em 23 de maio de 2017. RESUMO:Nesse trabalho propõe-se contribuir com as discussões sobre a exploração sustentável da Caatinga através de uma atualização bibliográfica sobre o tema, destacando a importância desse bioma, suas potencialidades e a necessidade de sua preservação e conservação. Foram abordadas a importância socioeconômica do bioma, as estratégias de subsistência e geração de renda (como o extrativismo e bioprodutos de valor econômico), as políticas públicas e ameaças, além de avaliar o seu uso sustentável. Com base no exposto, compreende-se que o manejo sustentável é uma possibilidade real, tecnicamente comprovada. Faz-se necessário um intenso processo de conscientização e capacitação de todos os atores envolvidos por meio da formulação de políticas públicas, que priorizem a realidade ambiental e socioeconômica do bioma, da geração, sistematização e disseminação de informações, da construção de uma matriz de incentivos adaptados à realidade local e do fortalecimento institucional, como forma de garantir a sobrevivência do ecossistema.Palavras-chave: bioma brasileiro; extrativismo sustentável; semiárido.ABSTRACT: This paper aims to contribute with the discussions about the sustainable exploitation of Caatinga through an updated review of such topic. The research highlights the importance of this biome, thus, proposing its potential, and also the need for its preservation and conservation. This study, more specifically, exposes the socio-economic importance of the biome, on subsistence and income generation strategies, discussing the extraction and bio-products of economic value, public policies and threats, and evaluation of its sustainable use. Thus, considering this discussion it is understood that sustainable management is a real possibility and technically proven. It is necessary an intense process of awareness and training of all involved actors through

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Antibacterial Activity and Anticancer Activity of Rosmarinus officinalis L. Essential Oil Compared to That of Its Main Components

Cited by 225 publications

References 19 publications

Antioxidative, anticancer and genotoxic properties of α-pinene on N2a neuroblastoma cells

Antioxidative, anticancer and genotoxic properties of α-pinene on N2a neuroblastoma cells

Chemical composition, antibacterial and antifungal activities of Cinamomum bejolghota bark oil from Thailand

Motivações socioeconômicas para a conservação e exploração sustentável do bioma Caatinga

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