Antibacterial activity and proposed action mechanism of a new class of synthetic tricyclic flavonoids

Abstract

Based on the strong antimicrobial activity observed, this new tricyclic flavonoid has a good potential for the design of new antimicrobial agents.

Antibacterial activity of flavonoids and their structure–activity relationship: An update review

“…Developing novel, potent, and unique antibacterial drugs is important to overcome bacterial resistance and increase effectiveness of therapies. Many researchers reported that new derivatives of flavonoids were more active than natural flavonoids against bacteria strains (Table ; Babii et al, ). For evaluation of the antibacterial activity of hybrids of chalcones and oxazolidinones, N‐{3‐[3‐fluoro‐4‐(3‐pyridin‐2‐yl‐acryloyl)‐phenyl]‐2‐oxo‐oxazolidin‐5‐ylmethyl}‐acetamide ( 126 ; containing both chalcone and oxazolidinone moieties) was synthesized and showed potent activity toward S .…”

“…aureus and E . coli with MIC values of 0.24 and 3.9 μg/ml, respectively (Babii et al, ). 2,3‐Dibromo‐1,3‐diphenylpropan‐1‐one derivative ( 154 ) with two Br substitution at the positions α and β (the synthetic chalcone derivatives) possessed antibacterial activity against S .…”

“…In the study of three flavonoids [techtochrysin ( 30 ), negletein ( 31 ), and quercitin‐3‐glucoside ( 65 )] against foodborne pathogens, 90–95% reduction in biofilms was observed (Rajendran et al, ). Synthesized tricyclic flavonoid ( 153 ) at low concentration caused not only the inhibition of bacterial growth (MIC: 0.24 μg/ml) but also killing bacterial cells via cell membrane integrity and cell agglutination (Babii et al, ). For investigating the development of new antibiotics, one promising strategy is inhibition of type 2 fatty acid synthase pathway (FAS II; essential for the synthesis of fatty acids).…”

Substance P enhances lactic acid and tyramine production in Enterococcus faecalis V583 and promotes its cytotoxic effect on intestinal Caco-2/TC7 cells

“…To a certain extent, in our study, aggregation of E. faecalis V583, may protect the bacteria from SP, but conversely in some cases aggregation/agglutination of bacteria is also known to be inherent of the mechanism of action of some antimicrobial peptides [28, 29]. In addition, aggregation of bacteria is often associated with hydrophobicity, and these two parameters can help to adhere to different surfaces including intestinal epithelial cells [30].…”

2-Alkylimino-4-(2-Hydroxyaryl)-1,3-Dithiols Derivatives

“…Recent studies on (1,3-dithiolium-2-yl)phenolates systems revealed that 1,3-dithiolium cations can act as acceptor groups in intramolecular charge-transfer processes [26,30,46,47]. Moreover, this type of compounds has been found to exhibit biological activity, in a particular case, against gram-positive and gram-negative bacteria [48][49][50][51][52][53][54][55][56][57][58]. Dithiolium systems are known for their reactivity at the C(2) -position towards nucleophiles [28].…”