Antibacterial Activity, Antioxidant Effect and Chemical Composition of Propolis from the Región del Maule,  Central Chile

Nina, Nélida; Quispe, Cristina; Jiménez‐Aspee, Felipe; Theoduloz, Cristina; Feresín, Gabriela Egly; Lima, Beatriz; Leiva, Elba; Schmeda-Hirschmann, Guillermo

doi:10.3390/molecules201018144

Cited by 83 publications

(62 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Samples 17 and 18 showed considerable activity against c. albicans. Antifungal effects have been described previously (Kujumgiev et al 1999;Moreno et al 1999;Sawaya et al 2002), although studies have also shown that propolis may have no anti-candidiasis effect (Nina et al 2015). In our study, there were large differences in anti-candidiasis efficacy, indicating differences in origin as a source of variability in the sample activity, an idea which is further supported by the observation that samples from the same region had similar antifungal properties.…”

Section: Discussionsupporting

confidence: 86%

“…The results are presented as MIC values (Table 1), except for e. coli since no antibacterial activity could be detected and all MIC values were above 50 mg/ml. Nina et al (2015) described limited activity of propolis samples from Argentina against e. coli, while others (Boyanova et al 2006;Kosalec et al 2007) found no inhibitory activity of Bulgarian and Brazilian propolis, respectively, against e. coli. Kosalec et al (2007) found MIC values of below 10.4 mg/ml against e. coli while testing Croatian propolis samples.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Components responsible for antimicrobial activity of propolis from continental and Mediterranean regions in Croatian

Gajger¹,

Pavlović²,

Bojić³

et al. 2017

Czech J. Food Sci.

View full text Add to dashboard Cite

Tlak Gajger I., Pavlović I., Bojić M., Kosalec I., Srečec S., Vlainić T., Vlainić J. Propolis is a popular subject of research worldwide due to its therapeutic potential. The antimicrobial activity of propolis appears to be promising but depends on many variables related to its origin such as the content of phenolics and flavonoids. To address this issue with Croatian propolis, which has two major origins (Mediterranean and continental), we exposed bacteria (escherichia coli and staphylococcus aureus) and yeasts (candida albicans and Aspergillus niger) to different propolis concentrations (two-fold microdilution method with TCC/formazan endpoint). Total phenolic and flavonoid content and chromatographic profile along with antioxidant activity were assessed. The majority of the 24 propolis samples tested exhibited potent antimicrobial activity against s. aureus bacteria and the yeast c. albicans. Most propolis samples also exhibited robust antioxidative capacity which correlated polyphenol and flavonoid content. To the best of our knowledge this is the first study in which the antimicrobial activity of Croatian propolis is correlated with its constituents.

show abstract

Section: Discussionsupporting

confidence: 86%

Section: Discussionmentioning

confidence: 99%

Components responsible for antimicrobial activity of propolis from continental and Mediterranean regions in Croatian

Gajger¹,

Pavlović²,

Bojić³

et al. 2017

Czech J. Food Sci.

View full text Add to dashboard Cite

show abstract

“…Propolis from Chile has been reported to contain nine flavones/flavonol derivatives, one flavanone, eight dihydroflavonols and nine phenyl-propanoids [43]. Cinnamic acid derivatives and flavonoids are capable of affecting bacterial membrane potential by interfering with ion permeability leading to inhibition of bacterial mobility [44].…”

Section: Discussionmentioning

confidence: 99%

Chitosan-propolis nanoparticle formulation demonstrates anti-bacterial activity against Enterococcus faecalis biofilms

et al. 2017

View full text Add to dashboard Cite

Propolis obtained from bee hives is a natural substance with antimicrobial properties. It is limited by its insolubility in aqueous solutions; hence ethanol and ethyl acetate extracts of Malaysian propolis were prepared. Both the extracts displayed antimicrobial and anti-biofilm properties against Enterococcus faecalis, a common bacterium associated with hospital-acquired infections. High performance liquid chromatography (HPLC) analysis of propolis revealed the presence of flavonoids like kaempferol and pinocembrin. This study investigated the role of propolis developed into nanoparticles with chitosan for its antimicrobial and anti-biofilm properties against E. faecalis. Bacteria that grow in a slimy layer of biofilm are resistant to penetration by antibacterial agents. The use of nanoparticles in medicine has received attention recently due to better bioavailability, enhanced penetrative capacity and improved efficacy. A chitosan-propolis nanoformulation was chosen based on ideal physicochemical properties such as particle size, zeta potential, polydispersity index, encapsulation efficiency and the rate of release of the active ingredients. This formulation inhibited E. faecalis biofilm formation and reduced the number of bacteria in the biofilm by ~90% at 200 μg/ml concentration. When tested on pre-formed biofilms, the formulation reduced bacterial number in the biofilm by ~40% and ~75% at 200 and 300 μg/ml, respectively. The formulation not only reduced bacterial numbers, but also physically disrupted the biofilm structure as observed by scanning electron microscopy. Treatment of biofilms with chitosan-propolis nanoparticles altered the expression of biofilm-associated genes in E. faecalis. The results of this study revealed that chitosan-propolis nanoformulation can be deemed as a potential anti-biofilm agent in resisting infections involving biofilm formation like chronic wounds and surgical site infections.

show abstract

“…It is extensively used for centuries, in foodstuffs and beverages to improve health related disorders. Propolis and geopropolis exhibited a wide variety of pharmacological properties, such as, anti-inflammatory, antioxidant, antitumor, antiulcer and for treatment of respiratory diseases (Berretta et al, 2017;Montenegro & Mejí as, 2013;Pippi et al, 2015;Nina et al, 2015). The antiviral activity of propolis from different geographic regions is known, since ancient times.…”

Section: Introductionmentioning

confidence: 99%

Antiviral Activity of Geopropolis Extract from Scaptotrigona Aff. Postica against Rubella Virus

Coelho¹,

Figueiredo²,

Negri³

et al. 2018

JFR

View full text Add to dashboard Cite

The search for functional foods, which possess bioactive substances, is a new trend for the obtention of alternative and more effective treatments of many diseases with fewer side effects. Geopropolis, elaborated by stingless bees, is a mixture of plant resin sources, wax and soil. In the geopropolis from Scaptotrigona affinis postica (Latreille, 1807), (Hymenoptera, Apidae, Meliponini) was not observed the presence of soil. In a previous study, the extract of geopropolis provided by the beekeeper, from S. postica of Barra do Corda, Maranhão State, exhibited potent antiviral activity against herpes simplex virus. In this study, the propolis extract was prepared experimentally and characterized by RP-HPLC-DAD-ESI-MS/MS. The objective of this study was to evaluate the antiviral activity of an experimentally prepared geopropolis extract from S. postica against Rubella Virus infected Statens Serum Institute Rabbit Cornea (SIRC) cells. Rubella virus infection of susceptible women during the first trimester of pregnancy, often results in a combination of birth defects in newborns. There is not an effective treatment for rubella virus infection. Different protocols were carried out to evaluate, the antiviral effect of geopropolis extract on the viral replication of infectious RV. Cell viability and cell proliferation assays indicated that this geopropolis was not toxic to cultured SIRC cells. In the viral binding assay, antiviral assay, real-time PCR, and transmission electron microscopy, was observed that different concentrations of geopropolis (17, 34 and 68 µg/mL) was able to inhibit the binding of virions to the cell receptor and the production of infectious RV particles in post treated and pre treated infected SIRC cells. The antiviral activity could to be attributed to the high contents of the apigenin derivatives, vicenin-2 and schaftoside. As far as we know, this is the first report about the antiviral activity of geopropolis from Scaptotrigona postica against a Togaviridae virus.

show abstract

Antibacterial Activity, Antioxidant Effect and Chemical Composition of Propolis from the Región del Maule, Central Chile

Cited by 83 publications

References 46 publications

Components responsible for antimicrobial activity of propolis from continental and Mediterranean regions in Croatian

Components responsible for antimicrobial activity of propolis from continental and Mediterranean regions in Croatian

Chitosan-propolis nanoparticle formulation demonstrates anti-bacterial activity against Enterococcus faecalis biofilms

Antiviral Activity of Geopropolis Extract from Scaptotrigona Aff. Postica against Rubella Virus

Contact Info

Product

Resources

About