Antibacterial activity of transition metal complexes with a tridentate NNO amoxicillin derived Schiff base. Synthesis and characterization

Abstract

From the reaction of amoxicillin (1) antibiotic with 2,6−diaminopyridine (2) an amoxicillin−based Schiff base (HL) (3) was obtained and its transition metal Schiff base complexes were synthesized. Spectroscopic and physicochemical techniques, namely, UV−Vis, FT−IR, 1H−NMR, EPR, mass spectrometry, molar conductance, magnetic susceptibility, molecular modelling, together with elemental and thermal analyses, were used to characterize the synthesized compounds. Spectral and magnetic data suggested an octahedral geometry for all the complexes and the general formulae [ML(H2O)3][PF6] (M(II) = Mn2+ (4), Co2+ (5), Ni2+ (6), Cu2+ (7), Zn2+ (8), was proposed for them, where L represents deprotonated tridentate NNO amoxycillin−derived Schiff base. All compounds were screened for antibacterial activity by using agar disc diffusion method. The zinc(II) complex exhibited promising bactericidal activity against E. coli and S. aureus.

Synthesis and characterization of microbial mediated cadmium oxide nanoparticles

“…The evolutionary mechanism of bacterial resistance needs to be controlled or reduced by search for sustainable alternative in the field of biomedicine and biotechnology (Anacona, Mago, & Camus, 2018; Karthik, Dhanuskodi, et al, 2018b; Savale, Ghotekar, Pansambal, & Pardeshi, 2017). These new techniques would enhance production capacity for synthesis of new antimicrobial agents from small experimanetal scales to large industrial scales by using advance technology.…”

An Investigation on the Electrochemical Behavior and Antibacterial and Cytotoxic Activity of Nickel Trithiocyanurate Complexes

“…When we compare these findings with antibacterial activity of complex 1 [27], it can be concluded that the ligand abb and especially its nickel complex have much better activities against S. aureus and comparable antibacterial activity on E. coli. One should expect higher antibacterial activity in compounds containing sulfur in the structure, but conformation, i.e., planarity vs. nonplanarity of ligands and possible π-π interactions play a very important role in binding to active sites [33,34].…”

The BIOLOGICAL EFFICACY OF MIXED LIGAND COPPER(II) COMPLEXES OF N(4)-SUBSTITUTED THIOSEMICARBAZONE AND DIIMINE CO-LIGANDS AS CHELATING N, N’- DONOR LIGAND

“…The minimum inhibitory concentration (MIC) of synthesized thiosemicarbazone ligands and copper(II) complexes (5 and 50 μg/ml) was investigated by agar disc diffusion [9,10] against Bacillus thuringiensis (Gram-positive) and Escherichia coli (Gram-negative) and reported in terms of mm. However, the test was performed in the agar medium with the positive (chloramphenicol) and negative controls (DMF).…”