Antibacterial and brine shrimp lethality tests of biflavonoids and derivatives of Rheedia gardneriana

Verdi, Luiz Gonzaga; Pizzolatti, Moacir Geraldo; Montanher, Ana Beatriz Pimentel; Brighente, Inês Maria Costa; Júnior, Artur Smânia; Smânia, Elza de Fátima Albino; Simionatto, Edésio Luiz; Monachè, Franco Delle

doi:10.1016/j.fitote.2003.12.023

Cited by 45 publications

(29 citation statements)

References 12 publications

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“…Such substances are for the first time identified in B. sartorum and seem to be correlated with the biological activities attributed to it. This finding is in accordance with the literature (Hamilton-Miller & Shah, 2000;Verdi et al, 2004) that describes polyphenols as potential antibacterial compounds against S. aureus. Vitis vinifera extracts, which are rich sources of monomeric phenolic compounds, such as (+)-catechins, (-)-epicatechin and (-)-epicatechin-3-O-gallate and dimeric, trimeric and tetrameric procyanidins, showed high antibacterial activity against Gram-positive bacteria (Jayaprakasha et al, 2003).…”

Section: Discussionsupporting

confidence: 93%

Antibacterial and antioxidant activities and acute toxicity of Bumelia sartorum Mart., Sapotaceae, a Brazilian medicinal plant

Ruela¹,

Leal²,

Almeida³

et al. 2011

Rev. bras. farmacogn.

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Abstract:In order to validate the Bumelia sartorum Mart., Sapotaceae, traditional use for infection diseases, this study evaluates the antibacterial activity of the stem bark fractions against methicillin-sensitive (MSSA) and methicillin-resistant (MRSA) Staphylococcus aureus strains by using the agar dilution method and reported as MIC (minimal inhibitory concentration). In addition, the DPPH scavenging activity of these fractions was measured and the chemical composition and acute toxicity of the active fraction were also determined. The ethyl acetate (EtOAc) extract was chemically analyzed by LC/ MS, direct ionization APCI/MS, 1 H NMR and 13 C-NMR. All fractions, except butanol extract, presented high antioxidant activity, especially the methanol and the EtOAc extracts, which showed EC50 values (5.67 and 5.30 µg/mL, respectively) considerably lower than the Gingko-standard EGb 761 ® (38.58 µg/ mL). The antibacterial activity against S. aureus strains was observed in EtOAc (MIC 256-512 µg/mL), which showed a very low toxicity. The chemical study of this fraction revealed the abundant presence of polyphenolic compounds. The antibacterial and antioxidant activities reported in this paper for EtOAc extract from B. sartorum and the low toxicity of this fraction opens the possibility that it could be helpful for the developing of new antibacterial agents for treating S. aureus infections.

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Section: Discussionsupporting

confidence: 93%

Antibacterial and antioxidant activities and acute toxicity of Bumelia sartorum Mart., Sapotaceae, a Brazilian medicinal plant

Ruela¹,

Leal²,

Almeida³

et al. 2011

Rev. bras. farmacogn.

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“…The activity of morelloflavone (1) as an antiinflammatory (Gil et al, 1997;Castardo et al, 2008) and antioxidant (Sanz et al, 1994;Deachathai et al, 2005;Hutadilok-Towatana et al, 2007) are well-documented; it has also been found to be a potent tyrosinase inhibitor (Masuda et al, 2005), anti-HIV-1 (Lin et al, 1997), and anti-bacterial (Verdi et al, 2004) agent, and to have antimalarial (Ngouamegne et al, 2008) and analgesic (Luzzi et al, 1997) properties. Isojacareubin (5) is known for its activity as an anticoagulant (Wu et al, 1998), and 6-deoxyisojacareubin (6) for its antifungal (Morel et al, 2002) and antibacterial (Kuete et al, 2007) properties, while sargaol (4) shows marked activity as an antioxidant (Nahas et al, 2007).…”

Section: Resultsmentioning

confidence: 99%

Non-toxic melanin production inhibitors from Garcinia livingstonei (Clusiaceae)

Mulholland

Mwangi

Dlova³

et al. 2013

Journal of Ethnopharmacology

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“…Secondary metabolites of Garcinia species have shown antioxidant, antibacterial and antitumoral activities (Xing-Cong et al, 2004;Verdi et al, 2004;Rui-Min et al, 2009;Jawed et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Gas Chromatography-Mass Spectrometry study of the pulp of Garcinia tinctoria<br>fruit

Arazo

Hernández

Bello

et al. 2014

Emir. J. Food Agric

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The aim of this work was to identify the compounds in the hexane extract of the mature fruits of Garcinia tinctoria by means of capillary gas chromatography-mass spectrometry (GC-MS). The study allowed identifying 51 chromatographic peaks. The mass spectra allowed the identification of 20 paraffins, 13 carboxylic acids and 15 phenolic and/or alcoholic compounds in the volatile fraction of hexane extract of pulp. The major compounds were: the stearic, palmitic and oleic acids.

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Antibacterial and brine shrimp lethality tests of biflavonoids and derivatives of Rheedia gardneriana

Cited by 45 publications

References 12 publications

Antibacterial and antioxidant activities and acute toxicity of Bumelia sartorum Mart., Sapotaceae, a Brazilian medicinal plant

Antibacterial and antioxidant activities and acute toxicity of Bumelia sartorum Mart., Sapotaceae, a Brazilian medicinal plant

Non-toxic melanin production inhibitors from Garcinia livingstonei (Clusiaceae)

Gas Chromatography-Mass Spectrometry study of the pulp of Garcinia tinctoria<br>fruit

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