Antibacterial and cellular behavior of PLA-based bacitracin and zataria multiflora nanofibers produced by electrospinning method

Çiftçi, Fatih; Duygulu, Nilüfer Evcimen; Yılmazer, Yasemin; Gündüz, Oğuzhan; Üstündağ, Cem Bülent

doi:10.1080/00914037.2021.2008391

Cited by 13 publications

(7 citation statements)

References 54 publications

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“…Poly(lactic acid) (PLA) [21], poly(vinyl alcohol) (PVA) [16,22], polyvinylpyrrolidone (PVP) [23][24][25], polyurethane (PU) [26], polyethylene glycol (PEG) [27], polycaprolactone (PCL) [28], polyethylene oxide (PEO), polylactic acid (PLGA), polystyrene (PS) and polyglycerol (PG), chitosan (CS), gelatin, pectin, collagen [18] are widely used in ES in the literature.…”

Section: Electrospinningmentioning

confidence: 99%

“…PLANT-BASED NANOFIBERS Many herbal extracts have been effectively used in nanofiber electrospinning technology. Some of the plants that have been used include Zataria multiflora [21,22], Salvia hispanica L. [19], Malva syvestris [26,54], Laurus nobilis [32], Rosmarinus officinalis [32], garlic [23,33], Bergamot [16], Melissa officinalis [27], Inula graveolens (L.) [28], Allium cepa L. [34,35], Juniperus chinensis [26], Panax Ginseng [36], Allium ursinum L. [37], Rhodomyrtus tomentosa [24], Opuntia ficus-indica [38], Garcinia mangostana L. [39], Lawsonia Inermis [40,41], Cleome droserifolia [42], Tridax Procumbens [43], Moringa oleifera [44].…”

Section: Plant and Plant Extractionsmentioning

confidence: 99%

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Nanofibers produced from medicinal and aromatic plant extracts by electrospinning method

2023

Proceeding Book of 3rd International Conference on Scientific and Academic Research ICSAR 2023

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Electrospinning (ES) is a fiber fabrication technology that uses electrical force with polymer solutions or polymer melts. ES is a flexible and economical technique for producing continuous nanoand microfiber membranes with tunable structures, properties, and functionalities. Since 2000, there have been significant advances in the field of electrospinning. ES has proven to be the most cost-effective, simple, and reliable method for producing nanofibers. ES is a carrier system that can be used for these purposes and is a suitable platform for the production of new materials. Many research studies have been conducted using both natural and synthetic polymers. In the ES process, bioactive chemicals are incorporated into polymers because of many advantages. Plant extracts are a storehouse of bioactive chemicals with medicinal applications. These medicinal and beneficial properties of plants can be transferred to nanofibers. Nanofibers are a subset of nanostructures. One of the most efficient methods to produce nanofibers is electrospinning. The aim of this review is to present a summary of some recent studies in which crude plant extracts have been loaded with various natural or synthetic polymers for applications.

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Section: Electrospinningmentioning

confidence: 99%

Section: Plant and Plant Extractionsmentioning

confidence: 99%

Nanofibers produced from medicinal and aromatic plant extracts by electrospinning method

2023

Proceeding Book of 3rd International Conference on Scientific and Academic Research ICSAR 2023

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“…In those situations, tissue engineering approaches are critical in terms of filling the bone defect with various materials to stimulate bone regeneration while providing structural and mechanical support. 4 Bone tissue engineering requires biomimetic scaffolds promoting cell adhesion, migration, and vascularization, as well as high-strength properties for load-bearing bones. However, it is still complicated to develop porous and biocompatible scaffolds with adequate mechanical strength.…”

Section: Introductionmentioning

confidence: 99%

“…Even though bone has the potential to heal and regenerate on its own, this regeneration is not always complete due to serious defects and fractures. In those situations, tissue engineering approaches are critical in terms of filling the bone defect with various materials to stimulate bone regeneration while providing structural and mechanical support 4 …”

Section: Introductionmentioning

confidence: 99%

Fabrication of biomimetic scaffold through hybrid forming technique

Celik,

Ustundag

2024

Int J Ceramic Engine & Sci

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Bone tissue engineering procedures require the use of a scaffold with a sufficiently porous structure, which serves as a three‐dimensional template for cell attachment, followed by tissue regeneration and vascularization both in vitro and in vivo. This study aimed to create scaffold material with a unique hybrid forming that met these parameters. Slip casting and freeze‐drying processes were used with a hybrid forming approach to create a bone scaffold based on hydroxyapatite (HA) mimicking the structure of cortical and cancellous bones, respectively. HA was synthesized by the wet chemical precipitation method. Fourier‐transform infrared spectroscopy, dynamic light scattering, X‐ray diffraction, thermogravimetric analysis‐differential thermal analysis, Brunauer‐Emmett‐Teller, He Pycnometer, and scanning electron microscope analyses were performed to characterize the scaffold. According to analysis results, HA particle size was found at 137.8 nm. The optimum sintering temperature was determined to be 1300°C. The specific surface area of the HA powder was measured as 55.11 m2/g. The total open porosity of the hybrid scaffold was calculated as 70%. Scaffold successfully substituted both cancellous and cortical layers of bone regarding structural characteristics, porosity, and mechanical strength. Considering morphological characteristics, a hybrid scaffold might facilitate vascularization, osteoinduction, and osteoconduction. Research findings suggest that the hybrid design strongly resembled natural bone and is suitable for both load‐bearing and non‐bearing bones.

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“…These can be the top three potential routes for nanofabrication: (1) decreasing in size to picotechnology; (2) more sophisticated nanodevice structures; (3) more organized nanoproducts such arrays of different inorganic nanotubes and aligned nanofibers [1-3].Electrospinning enables the production of nanofibers with adjustable fiber diameters, homogenous fiber distributions, greater wound exudate absorptions, and improved encapsulation efficiencies, among other benefits. Furthermore, adopting an appropriate drug delivery system with a high surface-to-volume ratio and a high drug loading capacity of fibers improves wound healing [4][5][6]. In this regard, polymer materials have been considered to be potentially effective drug delivery carriers due to their excellent pharmacokinetic properties.…”

mentioning

confidence: 99%

Mini-review of the bi-component nanofibrous scaffolds and drug delivery applications

Parın

2024

JIENS

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Drug delivery systems perform to improve the drug's efficacy and heal the affected region. Electrospun nanofibers are strong drug carriers as a scaffold due to their high specific surface area, easy processing, lightweight material. Fibrous scaffolds encapsulating functional bioactive agents are important for drug delivery applications, and they show higher encapsulation efficiency and higher drug loading capacity than various types of carrier materials such as hydrogels, micro/nanobeads, films, conventional fibers, and sponges. In comparison to conventional electrospinning, bi-component electrospinning where drug loading does not occur largely on the surface of the polymer matrix, core-shell nanofibers showed delayed release and a decrease in burst release because the drug was loaded into the core layer. The purpose of this mini-review is to investigate the production and applications of the drug-loaded bi-component nanofibers in structure core-shell, side-by-side, hollow nanofibers, and also emulsion nanofibers using co-axial nozzles. Further, the parameters which influence of these electrospinning process, such as working conditions and polymer properties, as well as drug delivery profile of the resulting nanofibers, have been outlined briefly. The limited clinical studies on the nanofibers have been discussed. Eventually, perspectives on the problems, possibilities, and new approaches for electrospinning advancements have been presented, as well.

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Antibacterial and cellular behavior of PLA-based bacitracin and zataria multiflora nanofibers produced by electrospinning method

Cited by 13 publications

References 54 publications

Nanofibers produced from medicinal and aromatic plant extracts by electrospinning method

Nanofibers produced from medicinal and aromatic plant extracts by electrospinning method

Fabrication of biomimetic scaffold through hybrid forming technique

Mini-review of the bi-component nanofibrous scaffolds and drug delivery applications

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