Antibacterial, antibiofilm, anti-inflammatory, and wound healing effects of nanoscale multifunctional cationic alternating copolymers

Hooshmand, Seyyed Emad; Ebadati, Arefeh; Hosseini, Elaheh; Vahabi, Amir Hossein; Oshaghi, Mojgan; Rahighi, Reza; Orooji, Yasin; Jahromi, Mirza Ali Mofazzal; Varma, Rajender S.; Hamblin, Michael R.; Karimi, Mahdi

doi:10.1016/j.bioorg.2021.105550

Cited by 12 publications

(3 citation statements)

References 53 publications

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“…Advanced anti-infective biomedical materials which meet the stringent requirement for applications in clinical settings are urgently required [ 67 ]. BC is a sustainable biopolymer with unique physical properties leading to its expansive potential in the biomedical field.…”

Section: Discussionmentioning

confidence: 99%

Enhanced Antimicrobial Activity of Biocompatible Bacterial Cellulose Films via Dual Synergistic Action of Curcumin and Triangular Silver Nanoplates

Garcia¹,

Mojićević²,

Milivojević

et al. 2022

IJMS

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Curcumin and triangular silver nanoplates (TSNP)-incorporated bacterial cellulose (BC) films present an ideal antimicrobial material for biomedical applications as they afford a complete set of requirements, including a broad range of long-lasting potency and superior efficacy antimicrobial activity, combined with low toxicity. Here, BC was produced by Komagataeibacter medellinensis ID13488 strain in the presence of curcumin in the production medium (2 and 10%). TSNP were incorporated in the produced BC/curcumin films using ex situ method (21.34 ppm) and the antimicrobial activity was evaluated against Escherichia coli ATCC95922 and Staphylococcus aureus ATCC25923 bacterial strains. Biological activity of these natural products was assessed in cytotoxicity assay against lung fibroblasts and in vivo using Caenorhabditis elegans and Danio rerio as model organisms. Derived films have shown excellent antimicrobial performance with growth inhibition up to 67% for E. coli and 95% for S. aureus. In a highly positive synergistic interaction, BC films with 10% curcumin and incorporated TSNP have shown reduced toxicity with 80% MRC5 cells survival rate. It was shown that only 100% concentrations of film extracts induce low toxicity effect on model organisms’ development. The combined and synergistic advanced anti-infective functionalities of the curcumin and TSNP incorporated in BC have a high potential for development for application within the clinical setting.

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Section: Discussionmentioning

confidence: 99%

Enhanced Antimicrobial Activity of Biocompatible Bacterial Cellulose Films via Dual Synergistic Action of Curcumin and Triangular Silver Nanoplates

Garcia¹,

Mojićević²,

Milivojević

et al. 2022

IJMS

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“…To address this issue, researchers have also proposed multiple strategies in recent years, including targeted functional modification, [34] porous nanostructures, [35] combined application of biofilm-degrading enzymes, [7] and cationic modification. [36][37][38] Furthermore, the penetration of metal nanoparticles in biofilm differs according to nanoparticle shape. Compared with blunt particles, nanoparticles with sharp shapes are more likely to pierce bacterial cell membranes, resulting in cytoplasmic leakage.…”

Section: Introductionmentioning

confidence: 99%

A Magnetic Cloud Bomb for Effective Biofilm Eradication

Qian

Zhang

et al. 2023

Adv Funct Materials

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Skin and soft tissue infection (SSTI) is an inflammatory condition caused by bacteria, and the eradication of biofilms is an important problem when treating such infections. Because of the low dispersibility and biofilm permeability of magnetic antibacterial materials, biofilm removal is difficult and infection persists. To solve these problems, inspired by conventional cloud bombs, a magnetic “nano‐cloud bomb” by adjusting the synthesis ratio to alter the shape of an assembled zeolitic imidazolate framework (ZIF), namely ZIF‐L‐Fe, is synthesized simply and rapidly. ZIF‐L‐Fe has a flower‐like clustered structure with sharp edges, which prevents the stacking of 2D ZIF nanoleaves, thereby enhancing the dispersion of Fe nanoparticles and increasing biofilm penetration under the action of magnetism. Additionally, ZIF‐L‐Fe retains the photothermal and catalytic properties of nanoparticles, which can kill methicillin‐resistant Staphylococcus aureus (MRSA) at low temperature and efficiently catalyze hydrogen peroxide (H2O2). Because of its magnetic effect, ZIF‐L‐Fe can rapidly penetrate biofilm, thus forming craters and destroying the local biofilm structure. Accordingly, the proposed strategy of clustered ZIF‐loaded delivery of Fe provides a novel concept that requires further development for clinical application to the treatment of biofilm infections.

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“…Considering the extensive repercussion of this pandemic, scientists must come up with novel and effective antiviral drugs [ 5 , 6 ], and need to find new antibacterial and antifungal compounds [ 7 , 8 ]. Indisputably, discovering highly efficient remedies for these infectious diseases has exponentially emerged as an area of focus [ 9 , 10 , 11 ]. In this context, the synthesis of various dithiocarbamates (DTCs), which revealed remarkable properties and diverse applications in bioorganic and medicinal chemistry such as fungicides and pesticides, crop protection agents and anticancer agents, is thoroughly crucial [ 12 , 13 , 14 , 15 , 16 , 17 , 18 ].…”

Section: Introductionmentioning

confidence: 99%

Synthesis of novel antibacterial and antifungal dithiocarbamate-containing piperazine derivatives via re-engineering multicomponent approach

Halimehjani

Dehghan

Tafakori

et al. 2022

Heliyon

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Antibacterial, antibiofilm, anti-inflammatory, and wound healing effects of nanoscale multifunctional cationic alternating copolymers

Cited by 12 publications

References 53 publications

Enhanced Antimicrobial Activity of Biocompatible Bacterial Cellulose Films via Dual Synergistic Action of Curcumin and Triangular Silver Nanoplates

Enhanced Antimicrobial Activity of Biocompatible Bacterial Cellulose Films via Dual Synergistic Action of Curcumin and Triangular Silver Nanoplates

A Magnetic Cloud Bomb for Effective Biofilm Eradication

Synthesis of novel antibacterial and antifungal dithiocarbamate-containing piperazine derivatives via re-engineering multicomponent approach

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