Antibacterial, Antioxidative and Anti-proliferative Activity against Human Colorectal Cell of Pimpinella brachycarpa

Ahn, Seon-Mi; Kim, Mi-Sun; Jung, In-Chang; Sohn, Ho-Yong

doi:10.11002/kjfp.2011.18.4.590

Cited by 11 publications

(1 citation statement)

References 13 publications

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“…Pimpinella brachycarpa, a member of the Apiaceae family, is a source of caffeoylquinic acid and is widely found in Asia, Europe, and Africa; it is used as a folk medicine in Korean culture to treat gastrointestinal tract upsets, asthma, insomnia, and coughs [ 103 ]. Aster scaber is a member of the Asteraceae family that contains (−)-4,5-dicaffeoylquinic acid and (−)-3,5-dicaffeoylmucoquinic acid; it is distributed across eastern Asia, particularly in Korea, and used to treat bruises, headaches, and dizziness [ 43 ].…”

Section: Role Of Dietary Phytochemicalsmentioning

confidence: 99%

Phytochemicals That Regulate Neurodegenerative Disease by Targeting Neurotrophins: A Comprehensive Review

Venkatesan

Kim

2015

BioMed Research International

150

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Alzheimer's disease (AD), characterized by progressive dementia and deterioration of cognitive function, is an unsolved social and medical problem. Age, nutrition, and toxins are the most common causes of AD. However, currently no credible treatment is available for AD. Traditional herbs and phytochemicals may delay its onset and slow its progression and also allow recovery by targeting multiple pathological causes by antioxidative, anti-inflammatory, and antiamyloidogenic properties. They also regulate mitochondrial stress, apoptotic factors, free radical scavenging system, and neurotrophic factors. Neurotrophins such as BDNF, NGF, NT3, and NT4/5 play a vital role in neuronal and nonneuronal responses to AD. Neurotrophins depletion accelerates the progression of AD and therefore, replacing such neurotrophins may be a potential treatment for neurodegenerative disease. Here, we review the phytochemicals that mediate the signaling pathways involved in neuroprotection specifically neurotrophin-mediated activation of Trk receptors and members of p75NTR superfamily. We focus on representative phenolic derivatives, iridoid glycosides, terpenoids, alkaloids, and steroidal saponins as regulators of neurotrophin-mediated neuroprotection. Although these phytochemicals have attracted attention owing to their in vitro neurotrophin potentiating activity, their in vivo and clinical efficacy trials has yet to be established. Therefore, further research is necessary to prove the neuroprotective effects in preclinical models and in humans.

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Section: Role Of Dietary Phytochemicalsmentioning

confidence: 99%