Antibacterial compounds in green microalgae from extreme environments: a review

Little, Shannon M.; Senhorinho, Gerusa N.A.; Saleh, Mazen; Basiliko, Nathan; Scott, John A.

doi:10.4490/algae.2021.36.3.6

Cited by 36 publications

(17 citation statements)

References 56 publications

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“…These results seem to be in perfect agreement with the data of biochemical compositions since a significant relationship between total antioxidant activity and total phenolic compounds has been reported [57,58]. It is worth noting that microalgae methanolic extracts seem to be particularly rich in flavonoids, and that terpenes and carbohydrate were present in moderate amount and alkaloids were also found at trace levels in [59,60]. Previously, a correlation between metabolites like flavonoids, terpenes and carbohydrates presence and antibacterial activities was established [59,60].…”

Section: Discussionsupporting

confidence: 85%

“…It is worth noting that microalgae methanolic extracts seem to be particularly rich in flavonoids, and that terpenes and carbohydrate were present in moderate amount and alkaloids were also found at trace levels in [59,60]. Previously, a correlation between metabolites like flavonoids, terpenes and carbohydrates presence and antibacterial activities was established [59,60].…”

Section: Discussionmentioning

confidence: 99%

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Characterization and Biotechnological Potential of Two Native Marine Microalgae Isolated from the Tunisian Coast

et al. 2021

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Microalgae are attracting considerable interest worldwide. In the present study, two native microalgae strains isolated from Tunisian cost were identified as Chlamydomonas sp. and Navicula sp. We characterized their pigment and protein contents, as well as their carbohydrate and lipid productivity. The predominant fatty acids were found to be α-linolenic acid (C18:3n-3) and palmitoleic acid (C16:1n-7) for Chlamydomonas sp. and Navicula sp. strains respectively. Microalgae methanol extracts showed important in vitro antibacterial activity against all tested gram negative bacteria. Antioxidant activities of methanol extracts were investigated by determining radical scavenging activity according to DPPH (2,2-diphenyl-1-picrylhydrazyl) and ABTS (2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid)) methods. MTT (3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide) assay showed that the newly isolated microalgae were not toxic and have potential application in the fish feeds domain as a supplement in fish meal. Also, the biosorption of cadmium from aqueous solutions by microalgae living cells was evaluated. Large removal capacities were obtained with values ranging from 89.8% to 99.38%. These results are very promising as a starting point for a potential application of these new isolates for in situ bioremediation of heavy metals contaminating aqueous systems.

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Section: Discussionsupporting

confidence: 85%

Section: Discussionmentioning

confidence: 99%

Characterization and Biotechnological Potential of Two Native Marine Microalgae Isolated from the Tunisian Coast

et al. 2021

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“…A novel bioprospecting approach is to explore unique habitats that presumably harbour strains with greater versatility and robustness [ 8 , 9 ]. These strains, which are currently underrepresented in culture collections [ 10 ] possess exceptional resilience to survive possible turbulences typical of large-scale open cultivation setups [ 8 ]. Though successful, this strategy is still not well exploited and more studies are still needed in order to unlock its full benefits.…”

Section: Introductionmentioning

confidence: 99%

Novel microalgae strains from selected lower Himalayan aquatic habitats as potential sources of green products

et al. 2022

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Microalgal biomass provides a renewable source of biofuels and other green products. However, in order to realize economically viable microalgal biorefinery, strategic identification and utilization of suitable microalgal feedstock is fundamental. Here, a multi-step suboptimal screening strategy was used to target promising microalgae strains from selected freshwaters of the study area. The resulting strains were found to be affiliated to seven closely-related genera of the family Scenedesmaceae, as revealed by both morphologic and molecular characterization. Following initial screening under upper psychrophilic to optimum mesophilic (irregular temperature of 14.1 to 35.9°C) cultivation conditions, superior strains were chosen for further studies. Further cultivation of the selected strains under moderate to extreme mesophilic cultivation conditions (irregular temperature of 25.7 to 42.2°C), yielded up to 74.12 mgL-1day-1, 19.96 mgL-1day-1, 48.56%, 3.34 μg/mL and 1.20 μg/mL, for biomass productivity, lipid productivity, carbohydrate content, pigments content and carotenoids content respectively. These performances were deemed promising compared with some previous, optimum conditions-based reports. Interestingly, the fatty acids profile and the high carotenoids content of the studied strains revealed possible tolerance to the stress caused by the changing suboptimal cultivation conditions. Overall, strains AY1, CM6, LY2 and KL10 were exceptional and may present sustainable, promising feedstock for utilization in large-scale generation of green products, including biodiesel, bioethanol, pigments and dietary supplements. The findings of this study, which exposed promising, eurythermal strains, would expand the current knowledge on the search for promising microalgae strains capable of performing under the largely uncontrolled large-scale cultivation settings.

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“…Optimal culture conditions for the algae will often be different from the conditions for the optimal production of the compounds of interest, as is the case for the production of carotene or antimicrobial fatty acids (Ruffell et al ., 2016 ; Molino et al ., 2018 ; Kaha et al ., 2021 ). As one could expect, protective secondary metabolites are often produced in response to stressors which will impair algal growth (Little et al ., 2021 ). However, there is no universal rule correlating harsher culture conditions with the accumulation of beneficial compounds.…”

Section: Discussion and Limitationsmentioning

confidence: 99%

Health benefits of microalgae and their microbiomes

Krohn

Menanteau–Ledouble

Hageskal

et al. 2022

Microbial Biotechnology

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Microalgae comprise a phylogenetically very diverse group of photosynthetic unicellular pro-and eukaryotic organisms growing in marine and other aquatic environments. While they are well explored for the generation of biofuels, their potential as a source of antimicrobial and prebiotic substances have recently received increasing interest. Within this framework, microalgae may offer solutions to the societal challenge we face, concerning the lack of antibiotics treating the growing level of antimicrobial resistant bacteria and fungi in clinical settings. While the vast majority of microalgae and their associated microbiota remain unstudied, they may be a fascinating and rewarding source for novel and more sustainable antimicrobials and alternative molecules and compounds. In this review, we present an overview of the current knowledge on health benefits of microalgae and their associated microbiota. Finally, we describe remaining issues and limitation, and suggest several promising research potentials that should be given attention.

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Antibacterial compounds in green microalgae from extreme environments: a review

Cited by 36 publications

References 56 publications

Characterization and Biotechnological Potential of Two Native Marine Microalgae Isolated from the Tunisian Coast

Characterization and Biotechnological Potential of Two Native Marine Microalgae Isolated from the Tunisian Coast

Novel microalgae strains from selected lower Himalayan aquatic habitats as potential sources of green products

Health benefits of microalgae and their microbiomes

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