Antibacterial effects of chitosan–tripolyphosphate nanoparticles: impact of particle size molecular weight

Sarwar, Atif; Katas, Haliza; Zin, Noraziah Mohamad

doi:10.1007/s11051-014-2517-9

Cited by 77 publications

(40 citation statements)

References 42 publications

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“…However, it must be noted that medium molecular weight CS-NPs were used in the present study and that a higher antibacterial effect may be achieved if a low molecular weight CS-NPs are used as reported earlier [22], [28].…”

Section: Discussionmentioning

confidence: 73%

Antibacterial activity against Streptococcus mutans and inhibition of bacterial induced enamel demineralization of propolis, miswak, and chitosan nanoparticles based dental varnishes

Wassel

Khattab

2017

Journal of Advanced Research

101

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Section: Discussionmentioning

confidence: 73%

Antibacterial activity against Streptococcus mutans and inhibition of bacterial induced enamel demineralization of propolis, miswak, and chitosan nanoparticles based dental varnishes

Wassel

Khattab

2017

Journal of Advanced Research

101

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“…Allan and Hadwiger first reported the antifungal properties of chitosan and suggested that chitosan does not only possess fungicidal properties, but is also more effective on a wider range of fungi than chitin [55]. Since then, several researchers have evaluated the antimicrobial nature of chitosan against different microorganisms and their action mechanisms, but no clear consensus on the mechanism of antimicrobial activity of chitosan has been reached [56][57][58][59][60]. Several mechanisms have been proposed to explain the antimicrobial properties of chitosan.…”

Section: Antimicrobial Propertiesmentioning

confidence: 99%

“…In acidic solutions (pH < 6.3) chitosan has a polycationic nature and the positively charged amino groups of chitosan interact with negatively charged components on microbial cell membranes, causing extensive alterations to the cell surface and membrane barrier properties, leading to leakage of intracellular contents that results in cell death. Tyagi et al have demonstrated this hypothesis through a mechanistic study of chitosan nanoparticles against Gram-positive bacteria, S. aureus [56]. As chitosan has pKa~6.3, in mildly acidic conditions it is protonated, leading to a reduction in osmotic stability affecting membrane disruption that may efficiently lead to alterations in cell permeability and leakage of intracellular contents, ultimately imbibing rupture of cell.…”

Section: Antimicrobial Propertiesmentioning

confidence: 99%

Chitosan Nanocomposite Coatings for Food, Paints, and Water Treatment Applications

et al. 2019

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Worldwide, millions of tons of crustaceans are produced every year and consumed as protein-rich seafood. However, the shells of the crustaceans and other non-edible parts constituting about half of the body mass are usually discarded as waste. These discarded crustacean shells are a prominent source of polysaccharide (chitin) and protein. Chitosan is a de-acetylated form of chitin obtained from the crustacean waste that has attracted attention for applications in food, biomedical, and paint industries due to its characteristic properties, like solubility in weak acids, film-forming ability, pH-sensitivity, biodegradability, and biocompatibility. We present an overview of the application of chitosan in composite coatings for applications in food, paint, and water treatment. In the context of food industries, the main focus is on fabrication and application of chitosan-based composite films and coatings for prolonging the post-harvest life of fruits and vegetables, whereas anti-corrosion and self-healing properties are the main properties considered for antifouling applications in paints in this review.

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“…The particle size and zeta potential of chitosan-TPP nanoparticles increased with the increase of chitosan concentration. The particle size distribution of chitosan-TPP nanoparticles prepared by low MW chitosan was much more homogenous than that prepared with high MW chitosan (Sarwar et al 2014). Drug release behavior of bovine serum albumin from chitosan-TPP nanoparticles was affected by the molecular weight, degree of deacetylation and concentration of chitosan .…”

Section: As the Carrier Of Nanoparticlesmentioning

confidence: 93%

Drug Delivery Applications of Chitosan and its Derivatives

Zhang

Mao

2015

Excipient Applications in Formulation Design and Drug Delivery

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The development of drug delivery systems always goes hand in hand with the advancement of material science. The novel synthetic or natural functional materials provide opportunities to design optimal drug delivery systems. Among these, chitosan and its derivatives exhibit excellent application future because of its prominent characteristics. In this chapter, research progress of chitosan and its derivatives for drug delivery, from structure to properties, from properties to its application were overviewed. The physicochemical properties, biological properties, biodegradability, safety evaluation and structure modification of chitosan were introduced. Furthermore, applications of chitosan and its derivatives in drug delivery including as the carrier of nanoparticles and microparticles, as coating material, as matrix of hydrogels, films and sustained release tablets, as stabilizers, as absorption enhancers, were discussed. Finally, the applications of chitosan and its derivatives in different administration routes, and their advantages for gene, protein and vaccine delivery, were reviewed. The numerous successful studies on exploitation and application of chitosan and its derivatives showed promising application future of these materials in drug delivery.

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Antibacterial effects of chitosan–tripolyphosphate nanoparticles: impact of particle size molecular weight

Cited by 77 publications

References 42 publications

Antibacterial activity against Streptococcus mutans and inhibition of bacterial induced enamel demineralization of propolis, miswak, and chitosan nanoparticles based dental varnishes

Antibacterial activity against Streptococcus mutans and inhibition of bacterial induced enamel demineralization of propolis, miswak, and chitosan nanoparticles based dental varnishes

Chitosan Nanocomposite Coatings for Food, Paints, and Water Treatment Applications

Drug Delivery Applications of Chitosan and its Derivatives

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