Antibacterial infection and immune-evasive coating for orthopedic implants

Chae, Kyomin; Jang, Woo Young; Park, Kijun; Lee, Jinhyeok; Kim, Hyunchul; Lee, Kyuho; Lee, Chang Kyu; Lee, Yeontaek; Lee, Soon Hyuck; Seo, Jungmok

doi:10.1126/sciadv.abb0025

Cited by 83 publications

(40 citation statements)

References 64 publications

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“…Also, the surface of neural devices can be chemically functionalized and coated with anti-inflammatory materials, which will show similar effects by minimizing foreign body responses. A surface modification technique can modify the surface of implants with a slippery surface inspired by the Nepenthes pitcher plant to achieve excellent repellency against bio-substances ( Chae et al., 2020 ). Inspired by this, the surface of a fiber-based neural interface can be modified to achieve immune evasiveness and therefore reduce the decay of performance caused by immune responses.…”

Section: Discussionmentioning

confidence: 99%

Recent advances in recording and modulation technologies for next-generation neural interfaces

Hong¹,

Yoon²,

Jo³

et al. 2021

iScience

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Summary Along with the advancement in neural engineering techniques, unprecedented progress in the development of neural interfaces has been made over the past few decades. However, despite these achievements, there is still room for further improvements especially toward the possibility of monitoring and modulating neural activities with high resolution and specificity in our daily lives. In an effort of taking a step toward the next-generation neural interfaces, we want to highlight the recent progress in neural technologies. We will cover a wide scope of such developments ranging from novel platforms for highly specific recording and modulation to system integration for practical applications of novel interfaces.

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Section: Discussionmentioning

confidence: 99%

Recent advances in recording and modulation technologies for next-generation neural interfaces

Hong¹,

Yoon²,

Jo³

et al. 2021

iScience

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show abstract

“…Remarkably, the adherence of both Pseudomonas aeruginosa and Methicillin-resistant Staphylococcus aureus was not observed in both the short and long term, indicating the excellent antifouling property and mechanical durability of the coated orthopaedic implant. These findings were attributed to the trapped air pockets within the hierarchical structure that effectively minimized contact between the bacterial suspension and the surface [ 155 ].…”

Section: Anti-biofilm Applications Of Superhydrophobic Nanocoatingmentioning

confidence: 99%

Superhydrophobic Nanocoatings as Intervention against Biofilm-Associated Bacterial Infections

Chan

Chieng

et al. 2021

Nanomaterials

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Biofilm formation represents a significant cause of concern as it has been associated with increased morbidity and mortality, thereby imposing a huge burden on public healthcare system throughout the world. As biofilms are usually resistant to various conventional antimicrobial interventions, they may result in severe and persistent infections, which necessitates the development of novel therapeutic strategies to combat biofilm-based infections. Physicochemical modification of the biomaterials utilized in medical devices to mitigate initial microbial attachment has been proposed as a promising strategy in combating polymicrobial infections, as the adhesion of microorganisms is typically the first step for the formation of biofilms. For instance, superhydrophobic surfaces have been shown to possess substantial anti-biofilm properties attributed to the presence of nanostructures. In this article, we provide an insight into the mechanisms underlying biofilm formation and their composition, as well as the applications of nanomaterials as superhydrophobic nanocoatings for the development of novel anti-biofilm therapies.

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“…(4) Bacterial invasion has already occurred during the preparation or transportation of the titanium implants. In short, once a bacterial invasion occurs, it will occur in the deep tissue around the titanium implant, making failure of implantation inevitable, and the effect of disinfection and systemic antibiotics will be minimal [ 32 , 33 , 34 ]. Staphylococcus aureus, Staphylococcus epidermidis, and Pseudomonas aeruginosa are the most common pathogens in titanium implant infections [ 35 ], and these bacteria are usually found in the titanium implants and accumulate, finally forming a hard biofilm (a matrix of hydrated polysaccharide secreted by the bacteria).…”

Section: Antibacterial Effectsmentioning

confidence: 99%

Titanium Implants and Local Drug Delivery Systems Become Mutual Promoters in Orthopedic Clinics

Gao

Zhao

et al. 2021

Nanomaterials

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Titanium implants have always been regarded as one of the gold standard treatments for orthopedic applications, but they still face challenges such as pain, bacterial infections, insufficient osseointegration, immune rejection, and difficulty in personalizing treatment in the clinic. These challenges may lead to the patients having to undergo a painful second operation, along with increased economic burden, but the use of drugs is actively solving these problems. The use of systemic drug delivery systems through oral, intravenous, and intramuscular injection of various drugs with different pharmacological properties has effectively reduced the levels of inflammation, lowered the risk of endophytic bacterial infection, and regulated the progress of bone tumor cells, processing and regulating the balance of bone metabolism around the titanium implants. However, due to the limitations of systemic drug delivery systems—such as pharmacokinetics, and the characteristics of bone tissue in the event of different forms of trauma or disease—sometimes the expected effect cannot be achieved. Meanwhile, titanium implants loaded with drugs for local administration have gradually attracted the attention of many researchers. This article reviews the latest developments in local drug delivery systems in recent years, detailing how various types of drugs cooperate with titanium implants to enhance antibacterial, antitumor, and osseointegration effects. Additionally, we summarize the improved technology of titanium implants for drug loading and the control of drug release, along with molecular mechanisms of bone regeneration and vascularization. Finally, we lay out some future prospects in this field.

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Antibacterial infection and immune-evasive coating for orthopedic implants

Cited by 83 publications

References 64 publications

Recent advances in recording and modulation technologies for next-generation neural interfaces

Recent advances in recording and modulation technologies for next-generation neural interfaces

Superhydrophobic Nanocoatings as Intervention against Biofilm-Associated Bacterial Infections

Titanium Implants and Local Drug Delivery Systems Become Mutual Promoters in Orthopedic Clinics

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