Antibacterial metal ion release from diamond-like carbon modified surfaces for novel multifunctional implant materials

Buchegger, Sascha; Vogel, Caroline; Herrmann, R.; Stritzker, B.; Wixforth, Achim; Westerhausen, Christoph

doi:10.1557/jmr.2016.275

Cited by 15 publications

(13 citation statements)

References 30 publications

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“…Doubling the fluence to 2 · 10 17 cm −2 or reducing it by a factor of two to 5 · 10 16 cm −2 leads to an increased ratio of 1.98, and 2.18, respectively. The shift of the G-Peak shows the same trend with the lowest wave number of 1554 cm −1 for the fluence that was shown to be optimal for this process 21 and higher wavenumbers of 1562 cm −1 and 1559 cm −1 for the halved and the doubled fluence. Both parameters are indicators for the sp 3 fraction 22 .…”

Section: Resultssupporting

confidence: 52%

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Smart antimicrobial efficacy employing pH-sensitive ZnO-doped diamond-like carbon coatings

Buchegger

Kamenac

Fuchs

et al. 2019

Sci Rep

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One of the main challenges in endoprosthesis surgeries are implant-associated infections and aseptic-loosenings, caused by wear debris. To combat these problems, the requirements to surfaces of endoprostheses are wear-resistance, low cytotoxicity and antimicrobial efficacy. We here present antimicrobial coatings with a smart, adaptive release of metal ions in case of infection, based on ZnO-nanoparticles embedded in diamond-like carbon (DLC). The Zn2+ ion release of these coatings in aqueous environments reacts and adapts smartly on inflammations accompanied by acidosis. Moreover, we show that this increased ion release comes along with an increased toxicity to fibroblastic cells (L929) and bacteria (Staphylococcus aureus subsp. aureus, resistant to methicillin and oxacillin. (ATCC 43300, MRSA) and Staphylococcus epidermidis (ATCC 35984, S. epidermidis). Interestingly, the antimicrobial effect and the cytotoxicity of the coatings increase with a reduction of the pH value from 7.4 to 6.4, but not further to pH 5.4.

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Section: Resultssupporting

confidence: 52%

“…Employing a plasma immersion ion implantation process to colloidal poly(vinylpyrrolidone) (PVP) films containing ZnO NPs, we prepare DLC-coatings and characterize these samples as described earlier 21 . Subsequently, we incubate the samples in aqueous solutions and measure their ion release kinetics.…”

Section: Resultsmentioning

confidence: 99%

Smart antimicrobial efficacy employing pH-sensitive ZnO-doped diamond-like carbon coatings

Buchegger

Kamenac

Fuchs

et al. 2019

Sci Rep

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“…A quantitative correlation between local shear rates and time-dependent detachment of cells might give further insight into the shear sensitivity of arbitrary cell-substrate-combinations. Interesting systems thereby include novel metal ion releasing implant materials [53] and osteoblasts. On the other hand, cell biologists may apply the DANI-setup to study the internal response of adaptive processes of adherent cells to shear flow.…”

Section: Discussionmentioning

confidence: 99%

Exploring the Limits of Cell Adhesion under Shear Stress within Physiological Conditions and beyond on a Chip

et al. 2016

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Cell adhesion processes are of ubiquitous importance for biomedical applications such as optimization of implant materials. Here, not only physiological conditions such as temperature or pH, but also topographical structures play crucial roles, as inflammatory reactions after surgery can diminish osseointegration. In this study, we systematically investigate cell adhesion under static, dynamic and physiologically relevant conditions employing a lab-on-a-chip system. We screen adhesion of the bone osteosarcoma cell line SaOs-2 on a titanium implant material for pH and temperature values in the physiological range and beyond, to explore the limits of cell adhesion, e.g., for feverish and acidic conditions. A detailed study of different surface roughness Rq gives insight into the correlation between the cells’ abilities to adhere and withstand shear flow and the topography of the substrates, finding a local optimum at Rq = 22 nm. We use shear stress induced by acoustic streaming to determine a measure for the ability of cell adhesion under an external force for various conditions. We find an optimum of cell adhesion for T = 37 °C and pH = 7.4 with decreasing cell adhesion outside the physiological range, especially for high T and low pH. We find constant detachment rates in the physiological regime, but this behavior tends to collapse at the limits of 41 °C and pH 4.

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“…The hardness was measured on a nanoindenter (MTSXP, MTS, Minneapolis, MN, USA) under a load of 2 mN, in a continuous stiffness measurement test pattern. The intrinsic stress was calculated using the Stoney formula [15,16], and the thickness of the silicon substrate and the film was measured with a three-dimensional white-light profiler (ManoMap-D, AEP, Columbus, OH, USA).…”

Section: Mechanical Testmentioning

confidence: 99%

Attempting AG-Doped Diamond-Like Carbon Film to Improve Seal Performance of Hydraulic Servo-Actuator

Zhao

Zhang

et al. 2020

Materials

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A hydraulic servo-actuator is a critical aircraft control device whose sealing performance directly affects the sensitivity and accuracy of the aircraft flight attitude. Foreign intrusive particles in hydraulic oil may induce the vulnerable friction pair wear and the seal leak; they may even lead to oil spill accidents. This work attempts to conduct a systematical investigation of Ag-doped diamond-like carbon (Ag-DLC) film to improve the seal performance. The failure of the servo-actuator was analyzed. Then, a series of Ag-DLC films was deposited; the structure and combined tribological performances of the Ag-DLC films were investigated. The results show that the intensity of the Ag (111) crystal face in the films increases with an increase of Ag content. The hardness, intrinsic stress, frictional coefficient, and wear rate of the films tend to decrease with the amount of doping metal. The a:C-Ag10.5% film exhibits optimal combined properties. The Ag doping makes the film toughness improve; both soft Ag particles and a graphitized top layer act as solid lubricants. Our findings may offer a novel approach to make DLC film applicable for improving the seal performance of hydraulic servo-actuator. Based on the experimental data, a mechanism behind the film modification of Ag-DLC film is also revealed.

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Antibacterial metal ion release from diamond-like carbon modified surfaces for novel multifunctional implant materials

Abstract: Abstract

Cited by 15 publications

References 30 publications

Smart antimicrobial efficacy employing pH-sensitive ZnO-doped diamond-like carbon coatings

Smart antimicrobial efficacy employing pH-sensitive ZnO-doped diamond-like carbon coatings

Exploring the Limits of Cell Adhesion under Shear Stress within Physiological Conditions and beyond on a Chip

Attempting AG-Doped Diamond-Like Carbon Film to Improve Seal Performance of Hydraulic Servo-Actuator

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