Antibacterial Surface Coating for Bone Scaffolds Based on the Dark Catalytic Effect of Titanium Dioxide

Wiedmer, David; Cui, Chen; Weber, Florian; Petersen, Fernanda Cristina; Tiainen, Hanna

doi:10.1021/acsami.8b12623

Cited by 22 publications

(18 citation statements)

References 60 publications

(141 reference statements)

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“…Therefore, novel solutions and biomaterials are being developed to support tissue regeneration. To date, numerous scaffolds based on ceramics (e.g., titanium dioxide [ 3 , 4 ]), metals [ 5 ], or natural and synthetic polymers [ 6 , 7 ]) have been developed and evaluated in terms of their biocompatibility and bioactivity.…”

Section: Introductionmentioning

confidence: 99%

Surface-Modified Poly(l-lactide-co-glycolide) Scaffolds for the Treatment of Osteochondral Critical Size Defects—In Vivo Studies on Rabbits

Krok-Borkowicz

Reczyńska

Rumian

et al. 2020

IJMS

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Poly(l-lactide-co-glycolide) (PLGA) porous scaffolds were modified with collagen type I (PLGA/coll) or hydroxyapatite (PLGA/HAp) and implanted in rabbits osteochondral defects to check their biocompatibility and bone tissue regeneration potential. The scaffolds were fabricated using solvent casting/particulate leaching method. Their total porosity was 85% and the pore size was in the range of 250–320 µm. The physico-chemical properties of the scaffolds were evaluated using scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy (EDX), X-ray diffractometry (XRD), X-ray photoelectron spectroscopy (XPS), Fourier transform infrared spectroscopy (FTIR), sessile drop, and compression tests. Three types of the scaffolds (unmodified PLGA, PLGA/coll, and PLGA/HAp) were implanted into the defects created in New Zealand rabbit femoral trochlears; empty defect acted as control. Samples were extracted after 1, 4, 12, and 26 weeks from the implantation, evaluated using micro-computed tomography (µCT), and stained by Masson–Goldner and hematoxylin-eosin. The results showed that the proposed method is suitable for fabrication of highly porous PLGA scaffolds. Effective deposition of both coll and HAp was confirmed on all surfaces of the pores through the entire scaffold volume. In the in vivo model, PLGA and PLGA/HAp scaffolds enhanced tissue ingrowth as shown by histological and morphometric analyses. Bone formation was the highest for PLGA/HAp scaffolds as evidenced by µCT. Neo-tissue formation in the defect site was well correlated with degradation kinetics of the scaffold material. Interestingly, around PLGA/coll extensive inflammation and inhibited tissue healing were detected, presumably due to immunological response of the host towards collagen of bovine origin. To summarize, PLGA scaffolds modified with HAp are the most promising materials for bone tissue regeneration.

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Section: Introductionmentioning

confidence: 99%

Surface-Modified Poly(l-lactide-co-glycolide) Scaffolds for the Treatment of Osteochondral Critical Size Defects—In Vivo Studies on Rabbits

Krok-Borkowicz

Reczyńska

Rumian

et al. 2020

IJMS

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“…TiO 2 surfaces can be irradiated by visible light or in the absence of light after proper modification, which solves the problems brought by ultraviolet (UV) irradiation like carcinogenic potential [ 7 ]. To shift the band gap of TiO 2 into the visible light region, Nagay et al incorporated nitrogen and bismuth into a TiO 2 coating on Ti implant surfaces.…”

Section: Chemical Treatments With Metallic Agentsmentioning

confidence: 99%

“…Utilizing this phenomenon, Wiedmer et al created sol-gel derived anatase TiO 2 coating on porous ceramic scaffolds and successfully obstructed S. epidermidis biofilm development in the presence of 3% H 2 O 2 . They further found that TiO 2 coatings pretreated with 30% H 2 O 2 could preserve some of the oxidative property even without an oxidative agent [ 7 ].…”

Section: Chemical Treatments With Metallic Agentsmentioning

confidence: 99%

“…For example, enamel demineralization caused by dental plaques is a common complication of orthodontic treatments [ 5 ]. Moreover, the oral biofilm is one of the risk factors of dental implant treatments, associated with peri-implant diseases [ 6 ] and could endanger the success of scaffolds in bone restauration [ 7 ]. Conventional systemic or local antibiotic treatments are insufficient to handle biomaterial-associated infections (BAI) now, for the abuse of antibiotics in recent decades has led to increasing drug-resistant bacteria [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

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Metallic Antibacterial Surface Treatments of Dental and Orthopedic Materials

et al. 2020

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The oral cavity harbors complex microbial communities, which leads to biomaterial-associated infections (BAI) during dental and orthopedic treatments. Conventional antibiotic treatments have met great challenges recently due to the increasing emergency of drug-resistant bacteria. To tackle this clinical issue, antibacterial surface treatments, containing surface modification and coatings, of dental and orthopedic materials have become an area of intensive interest now. Among various antibacterial agents used in surface treatments, metallic agents possess unique properties, mainly including broad-spectrum antibacterial properties, low potential to develop bacterial resistance, relative biocompatibility, and chemical stability. Therefore, this review mainly focuses on underlying antibacterial applications and the mechanisms of metallic agents in dentistry and orthopedics. An overview of the present review indicates that much work remains to be done to deepen the understanding of antibacterial mechanisms and potential side-effects of metallic agents.

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“…In addition to the cellular components of tissue engineering, the formation of an artificial tissue requires the presence of a scaffold, which behaves as a template for tissue growth in both the cellular and acellular approaches to tissue engineering. In addition to fulfilling its primary role as a cell carrier and new tissue foundation, scaffolds can also be equipped as pharmaceutical or bio molecule delivery vehicles (e.g., antibacterial [40][41][42][43] or growth factors [44]). As schematically shown in Figure 2, tissue engineering is a multidisciplinary research field founded on three major components: the scaffold, the cells, and growth factors.…”

Section: Figurementioning

confidence: 99%

Additive Manufacturing Techniques for Fabrication of Bone Scaffolds for Tissue Engineering Applications

Jahani¹,

Wang²,

Brooks³

2020

RPM

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Bone tissue engineering (BTE) as a modern and more effective treatment for bone defects has recently received lots of attention. One of the pivotal parts of BTE is the "scaffold", which functions as an indwelling carrier of cells and additives, as well as, providing a foundation for cell growth and eventually forming new, native-like bone. Up to now, many methods and materials have been employed to manufacture bone scaffolds. This review focuses on providing both basic knowledge of BTE as well as possible methods of scaffold manufacturing. We categorize the fabrication methods into; current conventional methods and newly emerging additive manufacturing (AM) techniques. The fundamental, capabilities and limitations of each technique is investigated, and the latest achievements are presented.

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Antibacterial Surface Coating for Bone Scaffolds Based on the Dark Catalytic Effect of Titanium Dioxide

Abstract: Wiedmer et al.

Cited by 22 publications

References 60 publications

Surface-Modified Poly(l-lactide-co-glycolide) Scaffolds for the Treatment of Osteochondral Critical Size Defects—In Vivo Studies on Rabbits

Surface-Modified Poly(l-lactide-co-glycolide) Scaffolds for the Treatment of Osteochondral Critical Size Defects—In Vivo Studies on Rabbits

Metallic Antibacterial Surface Treatments of Dental and Orthopedic Materials

Additive Manufacturing Techniques for Fabrication of Bone Scaffolds for Tissue Engineering Applications

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