Antibacterial surfaces by adsorptive binding of polyvinyl-sulphonate-stabilized silver nanoparticles

Abstract

This paper presents a novel and facile method for the generation of efficient antibacterial coatings which can be applied to practically any type of substrate. Silver nanoparticles were stabilized with an adsorbed surface layer of polyvinyl sulphonate (PVS). This steric layer provided excellent colloidal stability, preventing aggregation over periods of months. PVS-coated silver nanoparticles were bound onto amine-containing surfaces, here produced by deposition of an allylamine plasma polymer thin film onto various substrates. SEM imaging showed no aggregation upon surface binding of the nanoparticles; they were well dispersed on amine surfaces. Such nanoparticle-coated surfaces were found to be effective in preventing attachment of Staphylococcus epidermidis bacteria and also in preventing biofilm formation. Combined with the ability of plasma polymerization to apply the thin polymeric binding layer onto a wide range of materials, this method appears promising for the fabrication of a wide range of infection-resistant biomedical devices.

Nicotine promotes Streptococcus mutans extracellular polysaccharide synthesis, cell aggregation and overall lactate dehydrogenase activity

“…Gtfs are a family of enzymes that catalyze the transformation of glucosyl groups from one chemical component to another and contributes to S. mutans cariogenicity (25). S. mutans expresses three distinct Gtfs, GtfB, GtfC and GtfD.…”

In situ preparation of silver–polyacrylonitrile nanocomposite fibres

“…During the further course of the synthesis, this peak disappears. Its presence may be caused by sodium allylsulfonate, which forms a complex with silver ions [29,30].…”

Efficient surface modification of biomaterial to prevent biofilm formation and the attachment of microorganisms

“…Similar plasma set up was used for the in situ formation of Ag nanoparticles within a functional hydrocarbon matrix, with the ability to control the concentrating of incorporated silver component (Körner et al 2010(Körner et al , 2011. Silver nanoparticles bound to a plasma-deposited thin polymeric binding layer of allylamine were effective in preventing attachment of S. epidermidis and biofilm formation while supporting attachment and spreading of osteoblastic cells (Vasilev et al 2009(Vasilev et al , 2010. Phosphinestabilised silver maleimide complex deposited using plasma polymerization onto glass and non-woven polypropylene fabrics demonstrated cytocompatibility with Swiss mouse fibroblasts and human neonatal keratinocytes, while effectively limiting colonization by P. aeruginosa (Poulter et al 2009).…”