Antibacterials/losartan

Abstract

Antibacterials/losartan Toxic epidermal necrosis and lack of efficacy: case reportA woman [exact age at the time of reaction not stated] developed toxic epidermal necrolysis during treatment with isoniazid, rifampicin and ethambutol. Additionally, she exhibited lack of efficacy during treatment with losartan [not all dosage stated; routes not stated].At the age of 70 years, the woman was admitted to the hospital for renal biopsy. Two years ago, she presented with proteinuria and microscopic haematuria and was treated with losartan 25 mg/day. However, the urinary protein excretion level was increased to the nephrotic range and pretibial pitting oedema was noted despite losartan therapy i.e. lack of efficacy. From 14 years, she had a nontuberculous mycobacterial infection (NTM). She was positive for Mycobacterium intracellulare. She had received isoniazid, rifampicin and ethambutol for its treatment. However, she developed toxic epidermal necrolysis secondary to antibacterial therapy [duration of treatment to reaction onset not stated].Subsequently, the woman's antibacterial therapy was discontinued. During the current admission, she was diagnosed with immunotactoid glomerulopathy (ITG). In view of her evident history of antibacterial allergy, antibacterials' dosages were adjusted. After dose adjustment, she had stable renal function.