Antibiotic bead pouch versus negative pressure wound therapy at initial management of AO/OTA 42 type IIIB open tibia fracture may reduce fracture related infection: A retrospective analysis of 113 patients

Patterson, Joseph T.; Becerra, Jacob A.; Brown, Michael; Roohani, Idean; Zalavras, Charalampos G.; Carey, Joseph N.

doi:10.1016/j.injury.2022.12.018

Cited by 6 publications

(4 citation statements)

References 39 publications

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“…However, it was not until 1988 when two cases involving the use of gentamicin antibiotic beads in the treatment of pacemaker infections demonstrated the practical clinical application of the antibiotic bead pouch technique (Behrend, 1988). The most recent publication dedicated to this topic was in February 2023 (Patterson et al, 2023). The relatively rare indications and the heterogeneous patient population in which the technique is used may explain the limited number of publications on the topic.…”

Section: Results -The Antibiotic Bead Pouch In Literaturementioning

confidence: 99%

“…The use of an alternative chitosan sponge showed higher efficacy than PMMA, but it has not yet been established in clinical use analogous to the experimental setup (Rand and Wenke, 2017). Recently, Patterson et al (2023) reported the results of using the antibiotic bead pouch for infection prevention in Gustilo IIIb open tibial shaft fractures and compared the outcome to NPWT treatment. The antibiotic bead pouch group had a lower risk for FRI requiring debridement or amputation than the NPWT group (Patterson et al, 2023).…”

Section: Results -The Antibiotic Bead Pouch In Literaturementioning

confidence: 99%

“…Recently, Patterson et al (2023) reported the results of using the antibiotic bead pouch for infection prevention in Gustilo IIIb open tibial shaft fractures and compared the outcome to NPWT treatment. The antibiotic bead pouch group had a lower risk for FRI requiring debridement or amputation than the NPWT group (Patterson et al, 2023).…”

Section: Results -The Antibiotic Bead Pouch In Literaturementioning

confidence: 99%

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The antibiotic bead pouch – a useful technique for temporary soft tissue coverage, infection prevention and therapy in trauma surgery

Rupp

Walter

Szymski

et al. 2023

J. Bone Joint Infect.

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Abstract. Soft tissue defects resulting from trauma and musculoskeletal infections can complicate surgical treatment. Appropriate temporary coverage of these defects is essential to achieve the best outcomes for necessary plastic soft tissue defect reconstruction. The antibiotic bead pouch technique is a reasonable surgical approach for managing temporary soft tissue defects following adequate surgical debridement. This technique involves the use of small diameter antibiotic-loaded bone cement beads to fill the dead space created by debridement. By applying antibiotics to the bone cement and covering the beads with an artificial skin graft, high local dosages of antibiotics can be achieved, resulting in the creation of a sterile wound that offers the best starting position for soft tissue and bone defect reconstruction. This narrative review describes the rationale for using this technique, including its advantages and disadvantages, as well as pearls and pitfalls associated with its use in daily practice. In addition, the article provides a comprehensive overview of the literature that has been published since the technique was introduced in surgical practice.

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Section: Results -The Antibiotic Bead Pouch In Literaturementioning

confidence: 99%

Section: Results -The Antibiotic Bead Pouch In Literaturementioning

confidence: 99%

Section: Results -The Antibiotic Bead Pouch In Literaturementioning

confidence: 99%

See 1 more Smart Citation

The antibiotic bead pouch – a useful technique for temporary soft tissue coverage, infection prevention and therapy in trauma surgery

Rupp

Walter

Szymski

et al. 2023

J. Bone Joint Infect.

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“…The average prevalence of GAIIIB fractures was 28.4% in 2000-2009 and 25.1% in 2010-2022, with no significant differences between the periods 1,5,7,12,13,15,17,[19][20][21][22][23][24][25] .…”

Section: Gaiiib (Fig 3 Table 3)mentioning

confidence: 88%

Why Has the Outcome of Gustilo-Anderson Type III Fracture Not Improved over Two Decades?

Fujioka,

Fukui,

Idemitsu

et al. 2024

International Journal of Surgical Wound Care

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Introduction: Gustilo-Anderson type III injury is a complex injury that usually results from high-energy trauma. Such injuries tend to be intractable due to the high frequency of infection. Methods: A systematic review of the literature was performed using the MEDLINE database to investigate changes in infection rates in Gustilo-Anderson type III open fracture care over the past 20 years. Results: The results indicated that the incidence of postoperative infection in Gustilo-Anderson type III has not improved for approximately 20 years, occurring at a frequency similar to that in the early 20th century. Discussion and conclusion: The recommended treatment strategy for Gustilo-Anderson type III fractures is early initial debridement within 12 h and final bone coverage within 72 h. However, in reality, these ideal treatments are not always performed, which can lead to postoperative infection. Achieving early initial debridement and secondary bone coverage requires adequate resources in medical facilities, which is not viable as an immediate solution. Therefore, appropriate wound management should be performed to minimize the incidence of infection during the period awaiting surgery. Continuous irrigation therapy is considered a recommended treatment option.

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Treatment strategies for fracture-related infections with concurrent soft tissue damage

Alt,

Rupp,

Kerschbaum

et al. 2024

Unfallchirurgie

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Antibiotic bead pouch versus negative pressure wound therapy at initial management of AO/OTA 42 type IIIB open tibia fracture may reduce fracture related infection: A retrospective analysis of 113 patients

Cited by 6 publications

References 39 publications

The antibiotic bead pouch – a useful technique for temporary soft tissue coverage, infection prevention and therapy in trauma surgery

The antibiotic bead pouch – a useful technique for temporary soft tissue coverage, infection prevention and therapy in trauma surgery

Why Has the Outcome of Gustilo-Anderson Type III Fracture Not Improved over Two Decades?

Treatment strategies for fracture-related infections with concurrent soft tissue damage

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