Antibiotic Combined Hyperimmune Serum Therapy for Peste des Petits Ruminants Infected Goats

Islam, Rafiqul; Giasuddin, M; Rahman, Masudur; Kafi, M

doi:10.3329/bjvm.v1i1.1918

Cited by 11 publications

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“…The sero-prevalence results of this study could be compared with earlier findings of Razzaque et al (2004) who reported sero-prevalence of PPR in 36% sheep, 49.17% goats and 19.05% cattle from the district of Mymensingh. These results indicate that a certain percentage of sheep (27%) and goats (25%) in the district of Mymensingh have natural positive level of antibody titre against PPR which might protect against natural PPR challenge, as the humoral antibodies have shown to have a protective value in PPR (Bidjeh et al, 1999, Islam et al, 2003. Maternally derived antibodies against PPR in young animals could be detected up to 6 months of age but fall below the protection threshold level at 3.5 and 4.5 months in lambs and kids, respectively.…”

Section: Sero-surveillancementioning

confidence: 99%

“…Barrette et al, 1997, Das et al, 2007. Sero-prevalence(Razzaque et al, 2004), evaluation of C-ELISA(Sil et al, 2001), pathological investigation(Khan et al, 2005) and evaluation of antibiotic combined hyperimmune serum therapy(Islam et al, 2003) for PPR infected goats have been reported from Bangladesh. The sero-surveillance and immunization studies in sheep and goats against PPR with a commercial PPR-VAC ® would help to assess the feasibility to use vaccine to control PPR in small ruminants under field conditions.…”

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confidence: 99%

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Sero-surveillance and immunization in sheep and goats against peste des petits ruminants in Bangladesh

Banik

Podder

Samad

et al. 1970

Bangl. J. Vet. Med.

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The sero-surveillance and immunization studies on Peste des Petits Ruminants (PPR) in non-descriptive indigenous sheep and Black Bengal goats aged between 5 to 12 months were carried out in the district of Mymensingh during the period from June to November 2003. Sero-prevalence of PPR by using competitive enzyme linked immunosorbent assay (C-ELISA) was conducted on 100 sheep and 100 goats which were selected randomly from 10 different areas in the district of Mymensingh. Of the 100 sheep and 100 goats tested, 27% sheep and 25% goats had positive (â¥ 50) antibody titre. This indicates that 27% sheep and 25% goats might have the capability to resist natural PPR infection and accordingly, sero-monitoring could be required to give a better indication of nation herd immunity. The immunization study against PPR with a commercial PPR VACÂ® was conducted on 10 sheep and 10 goats by inoculating @ 1.0 ml vaccine / animal subcutaneously. The clinical, haematological, biochemical and antibody levels were determined at pre-immunization and at 7th, 14th and 21st day of postimmunization. The mean antibody titre at 7th, 14th and 21st day of post-immunization in sheep (38.28 Â± 4.34, 58.63 Â± 3.60 & 68.27 Â± 3.09) and goats (49.84 Â± 4.37, 63.23 Â± 3.64 & 76.60 Â± 4.07) were significantly (p < 0.01) increased in comparison to the respective pre-immunization mean titre of sheep (20.0 Â± 6.78) and goats (14.00 Â± 6.96). Results of haematological examination showed that the PPR VACÂ® has no effects on haemoglobin (Hb), erythrocyte sedimentation rate (ESR), packed celled volume (PCV) and total erythrocyte count (TEC). The TLC was markedly increased at all the stages of postimmunization in both sheep and goats but significantly (p < 0.05) increased at 21st day (10.08 Â± 1.55 103 / mm3) in sheep and at 14th day (14.76 Â± 0.84 103 / mm3) in goats in comparison to pre-immunization values of sheep (7.95 Â± 0.97 103 / mm3) and goats (9.00 Â± 1.28 103 / mm3). No distinct difference was observed on rectal temperature, pulse and respiratory rate between the pre- and post-immunization values which indicates PPR-VACÂ® has no clinical effects in vaccinated animals. No significant differences on calcium, albumin, total serum protein (TSP) and glucose levels were observed between the pre- and post-immunization values in both the sheep and goats. But the TSP in both the sheep 8.43 Â± 0.69 g/dl) and goats (8.26 Â± 0.50 g / dl) at 21st day of post-immunization increased insignificantly (p > 0.05) in comparison to the pre-immunization values of sheep (7.66 Â± 0.79 g / dl) and goats (7.89 Â± 0.92 g / dl). The results of humoral immune response produced by PPR-VACÂ® indicates the activity of the inoculated vaccine but challenge studies with virulent PPR virus would be required to confirm its efficacy. Key words: PPR, sheep, goats, sero-surveillance, C-ELISA, PPR-VACÂ®, haematology, biochemistry Â doi: 10.3329/bjvm.v6i2.2334 Bangl. J. Vet. Med. (2008). 6 (2): 185-190

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Section: Sero-surveillancementioning

confidence: 99%

mentioning

confidence: 99%

Sero-surveillance and immunization in sheep and goats against peste des petits ruminants in Bangladesh

Banik

Podder

Samad

et al. 1970

Bangl. J. Vet. Med.

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“…Outbreaks of the disease have been reported to be associated with high morbidity and mortality in unprotected goats and the disease is now considered endemic in Bangladesh (Barrette et al, 1997;Islam et al, 2001;Das et al, 2007). Sero-prevalence (Razzaque et al, 2004), sero-surveillance and immunization studies (Banik et al, 2008), evaluation of C-ELISA (Sil et al, 2001), pathological investigation (Khan et al, 2005) and evaluation of antibiotic combined hyperimmune serum therapy (Islam et al, 2003) for PPR infected goats have been reported from Bangladesh. The present study was aimed to know the immune status in the field and immune response in experimental level in both vaccinated and non-vaccinated goats.…”

Section: Resultsmentioning

confidence: 99%

Sero-surveillance and sero-monitoring of locally produced PPR vaccine in the field and experimental level

Kabir

Hossain

Ershaduzzaman

et al. 2016

Asian J. Med. Biol. Res

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Peste des Petits Ruminants (PPR) is a highly contagious, economically important viral disease of goats with high morbidity and mortality. To control the disease effectively a live attenuated vaccine is available in Bangladesh which is produced by Livestock Research Institute (LRI), Mohakhali, Dhaka. The study was carried out to determine the immune status and immune response against PPR in field and experimental Black Bengal goats. Sero-surveillance of PPR was conducted by using c-ELISA in non-vaccinated 240 goats in Gazipur, Sirajgonj and Barisal. Out of the 240 goats tested, of which only 39 (20.31%) goats had positive level of PPR antibodies while 16.25% (13 out of 80 goats) in Gazipur, 28.75% (23 out of 80 goats) in Barisal and 3.75% ((3 out of 80 goats)) in Sirajgonj. In case of sero-monitoring of PPR, the result revealed that vaccinated goats from Rajshahi showed high positive result and have higher seroprevalence where 75% (60 out of 80 goats) were seropositive and only 25% (20 out of 80 goats) are seronegative. These result indicated that vaccinated Rajshahi goats is more resistant for PPR virus than non vaccinated goats. In experimentally to perform sero-monitoring, 10 seronegative goats were selected and divided into two equal groups (A and B).The immunization study against PPR with a commercial PPR vaccine was conducted on 5 goats of group A by inoculating @ 1.0 ml vaccine / animal subcutaneously and group B kept as non-vaccinated. The antibody titres against PPR in goats were determined at 0 day on vaccination and after 21DPV, 180DPV and 365DPV. The results found that 100% (5 out 5goats) seronegative in both vaccinated goats of group A and non-vaccinated goats of group B at 0 day on vaccination. The mean negative titres± SD were 79.285±13.921 and 76.707±9.265 in vaccinated group A and group B, respectively. The mean positive titers ±SD were 20.201±2.480, 8.630±4.970 and 11.382±1.419 at 21DPV, 180DPV an 365DPV, respectively in group A (100% seropositive). In case of non-vaccinated group B, the mean negative titres±SD were 74.258±7.793, 77.726±9.142 and 82.965±7.492 at 21DPV, 180DPV and 365DPV, respectively (100% seronegative). As it is observed, the antibody titres remain at the level over the period of time that indicates the immune response against PPR. From this finding, it is said that PPR vaccine could produce immune response in goats for about one year or 365 days.Asian J. Med. Biol. Res. March 2016, 2(1): 33-37

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“…Moreover, the efficacy of drugs, in addition to their dose and prescribing pattern to treat animal diseases has not been ascertained yet in Bangladesh [9,10]. Earlier some studies have published drug prescribing pattern mostly concise with species specific or disease specific [2,11,12].…”

Section: Introductionmentioning

confidence: 99%

Epidemiology of Livestock and Poultry Diseases in Jhenaidah district of Bangladesh

Sayeed¹,

Islam²,

Nahar³

et al. 2020

Preprint

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A descriptive epidemiological study has been conducted using hospital database of Teaching Veterinary Hospital (TVH) at Jhenaidah Government Veterinary College (JGVC) from July 2018 to June 2019. The study aimed to estimate the proportionate prevalence of different livestock and poultry diseases along with their spatiotemporal distribution and drug prescribing pattern. A total of 960 clinical cases were recorded during the study period. Ectoparasitic cases were proportionately higher in cattle (25.2%), whereas Peste des Petits Ruminants (PPR) cases were more frequent in goat (53.4%). The proportionate prevalence of other cases in cattle was Fascioliasis (14.3%), Myiasis (11.2%) and Foot and Mouth Disease (FMD) (7.2%). The proportionate prevalence of other cases in goats were vitamin and mineral deficiency (12.3%), bloat (5.2%), abscess (4.7%), and dog bite (1.2%). Again, the proportionate prevalence of poultry diseases was Infectious Bursal Disease (41.2%), salmonellosis (33.4%), fowl cholera (13.7%) and pox (7.8%). Most of the cattle cases were highly prevalent during the summer season except fascioliasis. In goat, PPR was predominated in the rainy season whereas myiasis was in the winter. Around 92% of disease cases were spatially located within the 2.5 km radius of the TVH of JGVC where only 0.9% of disease cases came from >10km away from TVH of JGVC. Simple linear regression identified a significant relation (p=0.01) with the distance and number of diseased animals came to the hospital. Antimicrobials belonging to b-Lactam group were most frequently prescribed for both poultry (48.6%), cattle (32.5%) followed by goat (9.2%), however sulfar drugs (34.8%) were commonly prescribed for goat cases. This type of study is very novel in Jhenaidah region of Bangladesh that might contribute to the researchers for further investigation.

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Antibiotic Combined Hyperimmune Serum Therapy for Peste des Petits Ruminants Infected Goats

Cited by 11 publications

References 0 publications

Sero-surveillance and immunization in sheep and goats against peste des petits ruminants in Bangladesh

Sero-surveillance and immunization in sheep and goats against peste des petits ruminants in Bangladesh

Sero-surveillance and sero-monitoring of locally produced PPR vaccine in the field and experimental level

Epidemiology of Livestock and Poultry Diseases in Jhenaidah district of Bangladesh

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