Antibiotic Consumption, Resistance Data, and Prevention Strategies

Karabay, Oğuz; Baştuğ, Aliye; Öztürk, Rıfat Can; Sencan, İkbal; Aksoy, Mehmet; Şimşek, Hatice; Gözel, Mustafa Gökhan; Erdoğan, Haluk; Karlıdağ, E. G.; Aypak, Adalet; Gönen, İbak; Gürpinar, Emre Umut; İşli, Fatma; Yıldız, Sulhiye; Yarsan, Ender; Bodur, Hürrem

doi:10.4274/mjima.2018.35

Cited by 5 publications

(6 citation statements)

References 89 publications

(130 reference statements)

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“…After then, the cost of some antimicrobials was reimbursed by the Social Security Institution (SSI) to only inpatients and only with the approval of an Infectious Disease Specialist (IDS). This strategy has been suggested as a part of antimicrobial stewardship programs 2 . The effect of the restriction policy has also been reported in various studies that have demonstrated a significant reduction both in the amount of antibiotics used and a decrease in resistance rates 1,3,4 .…”

Section: Introductionmentioning

confidence: 90%

“…This strategy has been suggested as a part of antimicrobial stewardship programs. 2 The effect of the restriction policy has also been reported in various studies that have demonstrated a significant reduction both in the amount of antibiotics used and a decrease in resistance rates. 1,3,4 Although it may help to decrease uncontrolled consumption of broad-spectrum antimicrobials, hospitalization may still be needed in stable patients…”

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confidence: 87%

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Outpatient parenteral antimicrobial therapy (OPAT) is a treatment modality provided to the patients who are in need of antimicrobial treatment for bacterial, viral, or fungal infections, and do not require any care support except the implementation of the therapy.To combat antimicrobial resistance and provide rational use of broad-spectrum antimicrobials, a nationwide antibiotic restriction program (NARP) was started in 2003 in Turkey. 1,2 After then, the cost of some antimicrobials was reimbursed by the Social Security Institution (SSI) to only inpatients and only with the approval of an Infectious Disease Specialist (IDS). This strategy has been suggested as a part of antimicrobial stewardship programs.

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mentioning

confidence: 99%

“…To combat antimicrobial resistance and provide rational use of broad-spectrum antimicrobials, a nationwide antibiotic restriction program (NARP) was started in 2003 in Turkey. 1,2 After then, the cost of some antimicrobials was reimbursed by the Social Security Institution (SSI) to only inpatients and only with the approval of an Infectious Disease Specialist (IDS). This strategy has been suggested as a part of antimicrobial stewardship programs.…”

mentioning

confidence: 99%

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Efficacy and cost‐effectivity analysis of outpatient parenteral antimicrobial therapy unit in infectious disease clinical practices: Turkey perspective

Baştuğ

Öksüz

Kazancıoğlu

et al. 2021

Int J Clinical Practice

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Background Outpatient parenteral antimicrobial treatment (OPAT) has become a common treatment modality in developed countries. OPAT units are not widespread in Turkey, and their cost‐effectivity analysis has not been studied, yet. Aims To analyze the clinical efficacy and cost‐effectiveness of the OPAT unit, based on a 1000‐bed teaching hospital. Methods The records of patients, who were treated between October 2013 and December 2017, in an OPAT unit of a tertiary hospital in Ankara, were obtained retrospectively. The cost that would arise if the patients were hospitalized for the same treatment period with the same diagnosis was calculated and compared with the actual treatment cost of the patients in the OPAT unit. Results A total of 594 patients who received antimicrobial treatment at the OPAT unit were enrolled. The mean age of the patients was 55.39 ± 16.37 years and 313 (52.7%) were males. Based on the end‐of‐treatment goals, 98.5% of the patients reached the treatment goal. An indirect cost analysis revealed that the OPAT unit was 487.625 94 TL/129.008 78 $ less costly than inpatient parenteral antibiotic treatment. In other words, OPAT cost was 75% of the equivalent inpatient costs. It was also determined that a total of 7078 bed days and 11.9 bed days per person were saved. Conclusions OPAT units should be expanded increasingly in Turkey. The evaluation together with the health care system conditions in Turkey revealed that the OPAT program is safe, effective, and cost‐efficient.

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Section: Introductionmentioning

confidence: 90%

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confidence: 87%

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mentioning

confidence: 99%

mentioning

confidence: 99%

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Efficacy and cost‐effectivity analysis of outpatient parenteral antimicrobial therapy unit in infectious disease clinical practices: Turkey perspective

Baştuğ

Öksüz

Kazancıoğlu

et al. 2021

Int J Clinical Practice

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“…Antimicrobial resistance (AMR) is recognized as a grave global health threat [1,2]. AMR has already lengthened the course of infectious diseases and increased the mortality rates as well as treatment costs [3].…”

Section: Introductionmentioning

confidence: 99%

A cross-sectional study of antibiotic misuse among Chinese children in developed and less developed provinces

Sun

et al. 2020

J Infect Dev Ctries

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Introduction: Antimicrobial resistance is a global health crisis and primarily caused by antibiotic misuse. Antibiotic misuse among children is particularly concerning, and its prevalence may vary from region to region in China with different development levels. Methodology: Zhejiang and Shaanxi were selected to represent developed and less developed provinces in China, respectively. Data of 2924 parents in Zhejiang and 3355 parents in Shaanxi whose children were 0-13 years old were collected through multi-stage stratified cluster random sampling and a self-administrated questionnaire. Chi-square tests and logistic regression models were used for statistical analysis. Results: Compared to parents in Zhejiang, those in Shaanxi were more likely to keep antibiotics for children at home, to engage in self-medication with antibiotics for children, and to make their children take antibiotics prophylactically. While there were no significant provincial differences between parents’ requests for antibiotics during pediatric consultations, parents in Shaanxi province were more likely to receive prescribed antibiotics. Conclusions: Children in less developed provinces face higher risks of antibiotic misuse at home as well as when attending medical practitioners. Comprehensive educational interventions are required to improve antibiotic use for children all over China but particularly in less developed provinces such as Shaanxi. Furthermore, non-prescription sales and over-prescribing of antibiotics should be reduced by targeted strategies.

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