Antibiotic Dosing Considerations for Term and Preterm Infants

Drugs for the Prevention and Treatment of Sepsis in the Newborn

“…prematurity) can all impact drug exposure, efficacy and toxicity. A paucity of neonatal-specific studies contributes to the significant variation in dose recommendations characteristic of different formulary sources 4 . Standard regimens are often derived from older studies that are limited by lower representation of the extremely preterm neonate, use of intramuscular administration, small sample sizes, and extrapolation from older populations 5 .…”