Antibiotic exposure and asthma development in children with allergic rhinitis

Lin, Yi; Chen, Yen-Chun; Kuo, Chang-Hung; Chang, Yo-Chen; Huang, Hsin‐Yi; Yeh, Wei-Ju; Wu, Ting-Yi; Huang, Ming-Yii; Hung, Chih‐Hsing

doi:10.1016/j.jmii.2019.02.003

Cited by 15 publications

(10 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A longitudinal follow-up study found that early antibiotic exposures appeared to increase higher risk for atopy among children with <2 than with ≥2 household pets, as well as among children who were breastfed ≥4 than <4 months [ 14 ]. However, few studies considered associations of early antibiotics exposure with childhood health outcomes among children with different individual characteristics and early exposures [ 1 , 20 , 29 , 30 , 31 ], particularly in China where prevalences of asthma and allergies have rapidly increased in the past 20 years [ 32 , 33 , 34 , 35 ] and where antibiotics have been overused [ 1 , 36 ].…”

Section: Introductionmentioning

confidence: 99%

First-Year Antibiotics Exposure in Relation to Childhood Asthma, Allergies, and Airway Illnesses

Zou

Liu

Huang

et al. 2020

IJERPH

View full text Add to dashboard Cite

Background: Associations of early antibiotics exposures with childhood asthma, allergies, and airway illnesses are debated. Objectives: We aimed to investigate associations of first-year antibiotics exposure with childhood asthma, allergies, and airway illnesses. Methods: A cross-sectional study was conducted among preschoolers in Shanghai, China during 2011–2012. A questionnaire regarding household environment and lifestyles and childhood health outcomes was reported by the child’s parents. Results: In total, 13,335 questionnaires (response rate: 85.3%) were analyzed and 3049 (24.1%) children had first-year antibiotics exposure. In the multivariate logistic regression analyses, first-year antibiotics exposure had significant associations with the higher odds of lifetime-ever pneumonia (adjusted OR, 95% CI: 2.15, 1.95–2.37), croup (1.46, 1.24–1.73), wheeze (1.44, 1.30–1.60), asthma (1.38, 1.19–1.61), food allergy (1.29, 1.13–1.46), and allergic rhinitis (1.23, 1.07–1.41), and as well as current (one year before the survey) common cold (≥3 times) (1.38, 1.25–1.52), dry cough (1.27, 1.13–1.42), atopic dermatitis (1.25, 1.09–1.43), wheeze (1.23, 1.10–1.38), and rhinitis symptoms (1.15, 1.04–1.26). These associations were different in children with different individual characteristics (age, sex, family history of atopy, and district) and other early exposures (breastfeeding, home decoration, pet-keeping, and environmental tobacco smoke). Conclusions: Our results indicate that first-year antibiotics exposure could be a strong risk factor for childhood pneumonia, asthma, allergies, and their related symptoms. The individual characteristics and other early exposures may modify effects of early antibiotic exposure on childhood allergies and airway illnesses.

show abstract

Section: Introductionmentioning

confidence: 99%

First-Year Antibiotics Exposure in Relation to Childhood Asthma, Allergies, and Airway Illnesses

Zou

Liu

Huang

et al. 2020

IJERPH

View full text Add to dashboard Cite

show abstract

“…Based on previous studies published by the CCHH study and some other relevant studies, 30,31 3) household environmental characteristics, including keeping pets (yes or no), air pollution from solid fuels (yes or no), passive cigarette smoke exposure (yes or no), and household dampness (yes or no). In early life, prenatal, and first-year models, passive cigarette smoke exposure and household dampness corresponded to the situation of these variables in the corresponding period.…”

Section: Study Design and Populationmentioning

confidence: 99%

Modification of Food Allergy on the Associations between Early Life Exposure to Size-Specific Particulate Matter and Childhood Allergic Rhinitis

Wu,

Tang,

Wei

et al. 2024

Environ. Sci. Technol.

View full text Add to dashboard Cite

Previous studies have reported the association between particulate matter (PM) and childhood allergic rhinitis (AR). However, it is unclear whether food allergy (FA) modifies the PM−AR association. We aimed at evaluating the effect of the modification of FA on PM−AR association in preschool children. We adopted a cross-sectional study and conducted a questionnaire survey among preschool children aged 3−6 years in 7 cities in China from June 2019 to June 2020 to collect information on AR and FA. We used a combination of multilevel logistic regression and restricted cubic spline functions to quantitatively assess whether FA modifies the associations between size-specific PM exposure (1 × 1 km) and the risk of AR. The adjusted odds ratios (ORs) for AR among the children with FA as per a 10 μg/m 3 increase in early life PM 1 , PM 2.5 , and PM 10 were significantly higher than the corresponding ORs among the children without FA [e.g., OR: 1.58, 95% CI: (1.32, 1.90) vs 1.29, 95% CI: (1.18, 1.41), per 10 μg/m 3 increase in PM 1 ]. The interactions between FA and size-specific PM exposure and their effects on AR were statistically significant (all p-int < 0.001). FA, as an important part of the allergic disease progression, may modify the PM−AR association in preschool children.

show abstract

“…In this study, macrolides and penicillin groups were linked to an increased risk of developing asthma among younger children with AR. 65 …”

Section: Evidence-based Impact Of Antibiotic Administration On Gut Mi...mentioning

confidence: 99%

Current understanding of antibiotic-associated dysbiosis and approaches for its management

Kesavelu

Jog

2023

Therapeutic Advances in Infection

View full text Add to dashboard Cite

Increased exposure to antibiotics during early childhood increases the risk of antibiotic-associated dysbiosis, which is associated with reduced diversity of gut microbial species and abundance of certain taxa, disruption of host immunity, and the emergence of antibiotic-resistant microbes. The disruption of gut microbiota and host immunity in early life is linked to the development of immune-related and metabolic disorders later in life. Antibiotic administration in populations predisposed to gut microbiota dysbiosis, such as newborns, obese children, and children with allergic rhinitis and recurrent infections; changes microbial composition and diversity; exacerbating dysbiosis and resulting in negative health outcomes. Antibiotic-associated diarrhea (AAD), Clostridiodes difficile-associated diarrhea (CDAD), and Helicobacter pylori infection are all short-term consequences of antibiotic treatment that persist from a few weeks to months. Changes in gut microbiota, which persist even 2 years after antibiotic exposure, and the development of obesity, allergies, and asthma are among the long-term consequences. Probiotic bacteria and dietary supplements can potentially prevent or reverse antibiotic-associated gut microbiota dysbiosis. Probiotics have been demonstrated in clinical studies to help prevent AAD and, to a lesser extent, CDAD, as well as to improve H pylori eradication rates. In the Indian setting, probiotics ( Saccharomyces boulardii and Bacillus clausii) have been shown to reduce the duration and frequency of acute diarrhea in children. Antibiotics may exaggerate the consequences of gut microbiota dysbiosis in vulnerable populations already affected by the condition. Therefore, prudent use of antibiotics among neonates and young children is critical to prevent the detrimental effects on gut health.

show abstract

Antibiotic exposure and asthma development in children with allergic rhinitis

Cited by 15 publications

References 26 publications

First-Year Antibiotics Exposure in Relation to Childhood Asthma, Allergies, and Airway Illnesses

First-Year Antibiotics Exposure in Relation to Childhood Asthma, Allergies, and Airway Illnesses

Modification of Food Allergy on the Associations between Early Life Exposure to Size-Specific Particulate Matter and Childhood Allergic Rhinitis

Current understanding of antibiotic-associated dysbiosis and approaches for its management

Contact Info

Product

Resources

About