Antibiotic-loaded acrylic bone cements: An in vitro study on the release mechanism and its efficacy

Miola, Marta; Bistolfi, Alessandro; Valsania, María Carmen; Bianco, Carlotta; Fucale, Giacomo; Verné, Enrica

doi:10.1016/j.msec.2013.03.032

Cited by 33 publications

(28 citation statements)

References 16 publications

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“…Our results indicated that ALBC had the greatest decrease in strength after the first two weeks. Other studies also showed maximum reduction of mechanical properties after adding different additives in the first 14 days 17,40,41 . Following that, the cement strength increased on day 21 and 28.…”

Section: Discussionmentioning

confidence: 84%

Evaluation of the Effect of Ciprofloxacin and Vancomycin on Mechanical Properties of PMMA Cement; a Preliminary Study on Molecular Weight

Gandomkarzadeh

Moghimi

Mahboubi

2020

Sci Rep

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Antibiotic-loaded bone cement (ALBC) is commonly used in joint replacement therapy for prevention and treatment of bone infection and mechanical properties of the cement is still an important issue.The effects of ciprofloxacin and vancomycin was investigated on mechanical characterization of PMMA bone cement. Different properties of cement containing (0, 2.5, 5 and 10% W/W) antibiotics, including compressive and bending properties, microstructural, porosity and density were evaluated. Both antibiotics significantly reduced the density values and mechanical properties (compressive and flexural strength and modulus) in all groups in comparison to control over first two weeks (p < 0.05). This reduction was due to increased porosity upon antibiotic addition (3.05 and 3.67% for ciprofloxacin and vancomycin, respectively) in comparison to control (2.08%) (p < 0.001) and exposure to aqueous medium. Vancomycin as antibiotic with higher molecular weight (MW = 1485) had significant effect on compressive strength reduction of the cement at high amount compared to ciprofloxacin (MW = 367) (P < 0.01), there was no difference between two antibiotics at lower concentrations (P > 0.05). The effect of antibiotic loading is both molecular weight and drug content dependent. The time is also an important parameter and the second week is the probably optimum time to study mechanical behavior of ALBC.

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Section: Discussionmentioning

confidence: 84%

Evaluation of the Effect of Ciprofloxacin and Vancomycin on Mechanical Properties of PMMA Cement; a Preliminary Study on Molecular Weight

Gandomkarzadeh

Moghimi

Mahboubi

2020

Sci Rep

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“…Other authors further proved that the initial release is affected by the roughness of the ALBC (the higher the roughness, the greater the release), and the continuous release ability is affected by the porosity of ALBC [16, 22]. Miola et al conducted an in vitro study, which showed that the bone cement powders were similar in size and shape under scanning electron micrograph among the different brands of PMMA and that the compositional analyses did not evidence any significant difference [36]. Commercial bone cements have additional minor contents that serve different purposes, such as benzoyl peroxide as an initiator and zirconium dioxide (ZrO) or barium sulfate as radio-opacifier.…”

Section: Discussionmentioning

confidence: 99%

“…Commercial bone cements have additional minor contents that serve different purposes, such as benzoyl peroxide as an initiator and zirconium dioxide (ZrO) or barium sulfate as radio-opacifier. ZrO, for example, is also found under scanning electron microscopy in cured bone cements [36]. Whether the amount of ZrO or other minor contents in bone cement would affect the porosity and hence the elution efficacy of ALBC necessitates further investigation.…”

Section: Discussionmentioning

confidence: 99%

“…Looney et al reported that the strength increased in the first 1–2 weeks after the setting of bone cement [48]. Miola et al found that the compression strength of ALBC after 14 days of elution was greater than that before elution [36]. The authors explained this phenomenon by the possible late-polymerization, post-hardening, and post-curing processes [9].…”

Section: Discussionmentioning

confidence: 99%

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Elution and Mechanical Strength of Vancomycin-Loaded Bone Cement: In Vitro Study of the Influence of Brand Combination

et al. 2016

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Antibiotic-loaded bone cement (ALBC) is widely used in orthopaedic surgery for both prevention and treatment of infection. Little is known about the effect of different brand combinations of antibiotic and bone cement on the elution profile and mechanical strength of ALBC. Standardized specimens that consisted of one of the 4 brands of bone cement and one of the 3 brands of vancomycin were fashioned, producing 12 combinations of ALBC. Two dosages of vancomycin in 40g bone cement were used to represent the high (4g vancomycin) and low (1g vancomycin) dose groups. Concentrations of vancomycin elution from ALBC was measured for up to 336 hours. The ultimate compression strength was tested at axial compression using a material testing machine before and after elution. In both high-dose and low-dose groups, Lyo-Vancin in PALACOS bone cement resulted in the highest cumulative elution and Vanco in Simplex P bone cement resulted in the lowest elution (458% and 65% higher in high- and low-dose groups, respectively). The mechanical strength was not significantly compromised in all groups with low dose vancomycin (range: 70.31 ± 2.74 MPa to 87.28 ± 8.26MPa after elution). However, with the addition of high dose vancomycin, there was a mixed amount of reduction in the ultimate compression strength after cement aging, ranging from 5% (Vanco in Simplex P, 81.10 ± 0.48 MPa after elution) to 38% (Sterile vancomycin in CMW, 60.94 ± 5.74 MPa after elution). We concluded that the selection of brands of vancomycin and bone cement has a great impact on the release efficacy and mechanical strength of ALBC.

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“…When analyzed in terms of antimicrobial activity, higher drug concentrations achieved with Palacos fail to elicit enhanced efficacy. [21,[29][30][31][32][33][34] In contrast to the aforementioned studies, our results yielded similar drug concentrations with Palacos, CMW 3, and Simplex P. Despite the similar antibiotics concentrations, samples from Simplex P showed lower antibacterial activity. Decreased antibacterial activity from similar drug concentrations may be due the effect of different levels of heat generated during exothermic reaction of the drug molecule, or due to imprecise semi-quantitative methods for analyzing drug activity.…”

Section: Discussionmentioning

confidence: 50%

Antibiotic release and antibacterial efficacy in cement spacers and cement beads impregnated with different techniques: In vitro study

Atıcı

Şahin²,

Çavun³

et al. 2018

Eklem Hastalik Cerrahisi

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Antibiotic-loaded acrylic bone cements: An in vitro study on the release mechanism and its efficacy

Cited by 33 publications

References 16 publications

Evaluation of the Effect of Ciprofloxacin and Vancomycin on Mechanical Properties of PMMA Cement; a Preliminary Study on Molecular Weight

Evaluation of the Effect of Ciprofloxacin and Vancomycin on Mechanical Properties of PMMA Cement; a Preliminary Study on Molecular Weight

Elution and Mechanical Strength of Vancomycin-Loaded Bone Cement: In Vitro Study of the Influence of Brand Combination

Antibiotic release and antibacterial efficacy in cement spacers and cement beads impregnated with different techniques: In vitro study

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