Antibiotic-Loaded Hydrogel Coating for the Prevention of Local Infection  after Vertebral Surgery:  A Retrospective Cohort Analysis

Parbonetti, Giovanni; Puglisi, A; Rizzo, B.; Granata, Roberto

doi:10.52198/21.sti.39.ns1469

Cited by 3 publications

(1 citation statement)

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“…Most of the papers available on the DAC ® antibacterial coating refer to its use in hip and knee arthroplasty procedures, as well as revision and traumatology. For the first time in 2021, Parbonetti et al [71] described data related to the use of a DAC ® antibiotic-loaded system in instrumented vertebral surgery, where, as reported by recent literature, the incidence of peri-implant infections is significantly higher than surgical joint arthroplasty procedures [77]. The investigators retrospectively collected data related to a cohort of 73 consecutive patients who underwent primary or revision instrumented lumbar vertebral fusion for a degenerative spinal disorder with segmental instability.…”

Section: Resultsmentioning

confidence: 99%

The Intraoperative Use of Defensive Antibacterial Coating (DAC®) in the Form of a Gel to Prevent Peri-Implant Infections in Orthopaedic Surgery: A Clinical Narrative Review

Pressato¹,

Battista²,

Govoni

et al. 2023

Materials

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Periprosthetic joint infections (PJIs) in arthroplasty and osteosynthesis-associated infections (OAIs) in reconstructive surgery still represent a challenging complication in orthopaedics and traumatology causing a burden worsening the patient’s quality of life, for caregiver and treating physicians, and for healthcare systems. PJIs and OAIs are the result of bacterial adhesion over an implant surface with subsequent biofilm formation. Therefore, the clinical pathological outcome is a difficult-to-eradicate persistent infection. Strategies to treat PJIs and OAIs involve debridement, the replacement of internal fixators or articular prostheses, and intravenous antibiotics. However, long treatments and surgical revision cause discomfort for patients; hence, the prevention of PJIs and OAIs represents a higher priority than treatment. Local antibiotic treatments through coating-release systems are becoming a smart approach to prevent this complication. Hydrophilic coatings, loaded with antibiotics, simultaneously provide a barrier effect against bacterial adhesion and allow for the local delivery of an antibiotic. The intraoperative use of a hyaluronan (HY)-derivative coating in the form of a gel, loaded with antibiotics to prevent PJI, has recently raised interest in orthopaedics. Current evidence supports the use of this coating in the prophylaxis of PJI and IRIs in terms of clinical outcomes and infection reduction. Thus, the purpose of this narrative review is to assess the use of a commercially available HY derivative in the form of a gel, highlighting the characteristics of this biomaterial, which makes it attractive for the management of PJIs and IRIs in orthopaedics and traumatology.

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Section: Resultsmentioning

confidence: 99%

The Intraoperative Use of Defensive Antibacterial Coating (DAC®) in the Form of a Gel to Prevent Peri-Implant Infections in Orthopaedic Surgery: A Clinical Narrative Review

Pressato¹,

Battista²,

Govoni

et al. 2023

Materials

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Progress in Designing Therapeutic Antimicrobial Hydrogels Targeting Implant‐associated Infections: Paving the Way for a Sustainable Platform Applied to Biomedical Devices

Dini,

Borges,

Malheiros

et al. 2024

Adv Healthcare Materials

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Implantable biomedical devices have found widespread use in restoring lost functions or structures within the human body, but they face a significant challenge from microbial‐related infections, which often lead to implant failure. In this context, antimicrobial hydrogels emerge as a promising strategy for treating implant‐associated infections owing to their tunable physicochemical properties. However, the literature lacks a comprehensive analysis of antimicrobial hydrogels, encompassing their development, mechanisms, and effect on implant‐associated infections, mainly in light of existing in vitro, in vivo, and clinical evidence. Thus, this review addresses the strategies employed by existing studies to tailor hydrogel properties to meet the specific needs of each application. Furthermore, this comprehensive review critically appraises the development of antimicrobial hydrogels, with a particular focus on solving infections related to metallic orthopedic or dental implants. Then, preclinical and clinical studies centering on providing quantitative microbiological results associated with the application of antimicrobial hydrogels are systematically summarized. Overall, antimicrobial hydrogels benefit from the tunable properties of polymers and hold promise as an effective strategy for the local treatment of implant‐associated infections. However, future clinical investigations, grounded on robust evidence from in vitro and preclinical studies, are required to explore and validate new antimicrobial hydrogels for clinical use.

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Biodegradable interbody cages for lumbar spine fusion: Current concepts and future directions

2022

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Antibiotic-Loaded Hydrogel Coating for the Prevention of Local Infection after Vertebral Surgery: A Retrospective Cohort Analysis

Cited by 3 publications

References 0 publications

The Intraoperative Use of Defensive Antibacterial Coating (DAC®) in the Form of a Gel to Prevent Peri-Implant Infections in Orthopaedic Surgery: A Clinical Narrative Review

The Intraoperative Use of Defensive Antibacterial Coating (DAC®) in the Form of a Gel to Prevent Peri-Implant Infections in Orthopaedic Surgery: A Clinical Narrative Review

Progress in Designing Therapeutic Antimicrobial Hydrogels Targeting Implant‐associated Infections: Paving the Way for a Sustainable Platform Applied to Biomedical Devices

Biodegradable interbody cages for lumbar spine fusion: Current concepts and future directions

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