Antibiotic Prophylaxis with a Single Dose of Cefazolin During Pacemaker Implantation: Incidence of Long‐Term Infective Complications

Bertaglia, Emanuele; Zerbo, Francesca; Zardo, Susanna; Barzan, Daniela; Zoppo, Franco; Pascotto, Pietro

doi:10.1111/j.1540-8159.2006.00294.x

Cited by 47 publications

(37 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Implantation of a new system compared with partial or complete system replacement and use of periprocedural antimicrobial prophylaxis were both associated with a lower risk of infection (Klug et al, 2007). There is evidence that perioperative antimicrobial prophylaxis is associated with a reduction in CIED infections (Bertaglia et al, 2006;Da Costa et al, 1998b;de Oliveira et al, 2009). Other small studies suggest that pectoral transvenous device placement is associated with significantly lower rates of CIED infection than those implanted abdominally or by thoracotomy.…”

Section: Risk Factorsmentioning

confidence: 99%

“…A following observational study was performed to assess the safety and long-term efficacy of a simple scheme of antibiotic prophylaxis, and to identify the predictors of long-term infective complications in patients undergoing pacemaker implantation or replacement. This study showed the efficacy of a single dose of cefazolin in preventing infective complications (Bertaglia et al, 2006). Finally a prospective, randomized, double-blinded, placebo-controlled trial was developed to determine whether prophylactic antibiotic administration reduces the incidence of infection related to device implantation was.…”

Section: Pharmacological Strategiesmentioning

confidence: 99%

See 1 more Smart Citation

Infections of Cardiac Implantable Electronic Devices: Etiology, Prevention and Treatment

Chelazzi¹,

Selmi²,

Vitali³

et al. 2011

Aspects of Pacemakers - Functions and Interactions in Cardiac and Non-Cardiac Indications

View full text Add to dashboard Cite

Section: Risk Factorsmentioning

confidence: 99%

Section: Pharmacological Strategiesmentioning

confidence: 99%

Infections of Cardiac Implantable Electronic Devices: Etiology, Prevention and Treatment

Chelazzi¹,

Selmi²,

Vitali³

et al. 2011

Aspects of Pacemakers - Functions and Interactions in Cardiac and Non-Cardiac Indications

View full text Add to dashboard Cite

“…During long-term follow-up, major infectious complications were observed in six patients (0.7 %). 37 A randomised controlled prospective study comparing CIED implantation with or without cefazolin prophylaxis was undertaken but prematurely discontinued after reaching 65 % of the planned enrolment, due to appearance of a significant difference in favour of the antibiotic arm (0.63 versus 3.28 infected patients, p=0.016). 38 Although vancomycin is not generally recommended, it may be considered as an alternative at centres where oxacillin resistance is high.…”

Section: Treatment and Preventionmentioning

confidence: 99%

Management of Cardiac Implantable Electronic Device Infection

Podoleanu

Deharo

2014

Arrhythm Electrophysiol Rev

View full text Add to dashboard Cite

The increasing use of cardiac implantable electronic devices (CIEDs) for management of cardiac conditions has over the last few years been associated with higher infection rates.1 Expanded CIED use alone cannot account for this rise, 2-4 which involves both patient-and device-related factors. Indeed patients are tending to be older and presenting with co-morbidities, while devices are becoming more sophisticated and requiring more leads and revision. 6 In terms of patient demographics, the occurrence of CIED infection was greatest in white males over 65 years of age, and the most significant associated co-morbidities were renal failure, respiratory failure, heart failure and diabetes. The greatest risk factors for mortality were respiratory failure (odds ratio [OR] 13.58; 95 % confidence interval [CI] 12.88-14.3), renal failure (OR 4.28; 95 % CI 4.04-4.53) and heart failure (OR 2.71; 95 % CI 2.54-2.88). Post-operative haematoma was more frequent in patients who developed infection. Sites reporting higher infection rates had sicker patients and lower overall procedure volumes. AbstractDespite improved preventive measures, infection associated with the use of cardiac implantable electronic devices (CIEDs) to treat often life-threatening conditions is rising at an average annual rate of almost 5 %. This rise is being driven by the increasing complexity of CIED technology and by the advancing age and co-morbidities of the patients. Although CIED infection is usually suspected based on local signs at the generator pocket site, diagnosis can be challenging in patients presenting no local manifestations or symptoms. Diagnostic methods include microbiological testing and echocardiography, and may be completed by positron emission tomography (PET)/computed tomography (CT) scan in selected cases. CIED infection requires a multidisciplinary approach in view of hardware extraction, targeted antibiotic therapy and reimplantation on an as-needed basis. Antibiotic prophylaxis targeting staphylococcal flora is recommended but the relation of these infections to medical care exposes patients to multi-resistant bacteria. New preventive measures utilising an antibacterial sleeve look promising. Treatment can be started on an empirical basis using an antistaphylococcal agent but must be continued using targeted antibiotic therapy. Crucial questions remain as to the best prevention strategy, optimal duration and timing of antibiotic therapy, and the most effective reimplantation technique.

show abstract

“…13,17,18 On the other hand, antibiotic prophylaxis seems to reduce the risk of infection. 19,20 Making the Diagnosis Pathogenesis CIED infections can be broadly categorized as follows:…”

Section: Scope Of the Problemmentioning

confidence: 99%

Device Infections

2013

View full text Add to dashboard Cite

Antibiotic Prophylaxis with a Single Dose of Cefazolin During Pacemaker Implantation: Incidence of Long‐Term Infective Complications

Abstract: Our data indicate the safety and efficacy of a single, intravenous 2 g dose of cefazolin in preventing infective complications related to pacemaker implantation or replacement. No clinical or procedural variable predicted the occurrence of long-term infective complications.

Cited by 47 publications

References 17 publications

Infections of Cardiac Implantable Electronic Devices: Etiology, Prevention and Treatment

Infections of Cardiac Implantable Electronic Devices: Etiology, Prevention and Treatment

Management of Cardiac Implantable Electronic Device Infection

Device Infections

Contact Info

Product

Resources

About