Antibiotic Residues in Food Chains; Impact on the  Environment and Human Health: A Review

Shahid, Aiman; Akhtar-Ali, Muhammad; Muzammil, Saima; Aslam, Bilal; Shahid, Muhammad Akbar; Saqalein, Muhammad; Akash, Muhammad Sajid Hamid; Almatroudi, Ahmad; Allemailem, Khaled S.; Khurshid, Mohsin

doi:10.15666/aeer/1905_39593977

Cited by 7 publications

(9 citation statements)

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“…In their studies of antibiotic residues in humans, they found teratogenic consequences and reproductive issues (Arsène et al, 2022). Early prenatal exposure to benzimidazole and anthelmintics may harm the fetus (Shahid et al, 2021). Oxfendazole, a benzimidazole, is also mutagenic.…”

Section: Impact On Public Healthmentioning

confidence: 99%

“…Oxfendazole, a benzimidazole, is also mutagenic. Enrofloxacin inhibits DNA gyrase from having antibacterial effects (Shahid et al, 2021). Thus, antibiotic residues in the environment and food chain represent a variety of health risks, from antibiotic resistance and allergic reactions to carcinogenic and mutagenesis effects on human health.…”

Section: Impact On Public Healthmentioning

confidence: 99%

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A comprehensive review on the fate and impact of antibiotic residues in the environment and public health: A special focus on the developing countries

Sikder,

Toha,

Anik

et al. 2024

Water Environment Research

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The widespread application of antibiotics in human and veterinary medicine has led to the pervasive presence of antibiotic residues in the environment, posing a potential hazard to public health. This comprehensive review aims to scrutinize the fate and impact of antibiotic residues, with a particular focus on the context of developing nations. The investigation delves into the diverse pathways facilitating the entry of antibiotics into the environment and meticulously examines their effects on human health. The review delineates the current state of antibiotic residues, evaluates their exposure in developing nations, and elucidates existing removal methodologies. Additionally, it probes into the factors contributing to the endurance and ecotoxicity of antibiotic residues, correlating these aspects with usage rates and associated mortalities in these nations. The study also investigates removal techniques for antibiotic residues, assessing their efficiency in environmental compartments. The concurrent emergence of antibiotic‐resistant bacteria, engendered by antibiotic residues, and their adverse ecological threats underscore the necessity for enhanced regulations, vigilant surveillance programs, and the adoption of sustainable alternatives. The review underlines the pivotal role of public education and awareness campaigns in promoting responsible antibiotic use. The synthesis concludes with strategic recommendations, strengthening the imperative for further research encompassing comprehensive monitoring, ecotoxicological effects, alternative strategies, socio‐economic considerations, and international collaborations, all aimed at mitigating the detrimental effects of antibiotic residues on human health and the environment.Practitioner Points Antibiotic residues are widely distributed in different environmental compartments. Developing countries use more antibiotics than developed countries. Human and veterinary wastes are one of the most responsible sources of antibiotic pollution. Antibiotics interact with biological systems and trigger pharmacological reactions at low doses. Antibiotics can be removed using modern biological, chemical, and physical–chemical techniques.

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Section: Impact On Public Healthmentioning

confidence: 99%

Section: Impact On Public Healthmentioning

confidence: 99%

A comprehensive review on the fate and impact of antibiotic residues in the environment and public health: A special focus on the developing countries

Sikder,

Toha,

Anik

et al. 2024

Water Environment Research

View full text Add to dashboard Cite

show abstract

“…Approximately 80% of animals used in food production are treated with veterinary medicines during part or all of their lives (Pavlov et al 2008 ). Narrow-spectrum antibiotics should be the first choice of antimicrobial agents (Shahid et al 2021 ). Antibiotics commonly used for prophylaxis, growth promotion, and treatment in food animals are sulfamethoxazole, enrofloxacin, benzylpenicillin, tylosin, amoxicillin, trimethoprim, oxytetracycline, ampicillin, and streptopenicillin; amikacin, neomycin, enrofloxacin, doxycycline, tetracycline, tilmicosin, and colistin sulfate (Chattopadhyay 2014 ; Redwan Haque et al 2023 ).…”

Section: Antibiotics Used In Foodstuffsmentioning

confidence: 99%

“…Various sources contribute to this pool of antibiotic residues, such as livestock, dairies, veterinarians, pets, poultry, hospital waste disposal, animal feces, pharmaceutical factories, and municipal waste (Obayiuwana et al 2018 ). These residues and metabolites indirectly contaminate water and soil; for example, a polyether antibiotic, monensin, used in dairy farms to stimulate animal growth, has been found to spread to natural sources (Shahid et al 2021 ). Therefore, these compounds can enter the human food chain from the environment (Rafiq et al 2022 ).…”

Section: Antibiotics Used In Foodstuffsmentioning

confidence: 99%

“…In addition, overuse of antibiotics can lead to the development of resistance, which can directly and indirectly affect bacterial populations and result in failure to treat infections. In fact, it is mainly emphasized that antibiotic residues in food cause these toxic effects (Shahid et al 2021 ). Although the effects of antibiotic residues on human health are predicted, the potential harm to environmental health is generally unknown (Ngangom et al 2019 ).…”

Section: Introductionmentioning

confidence: 99%

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The two faces of antibiotics: an overview of the effects of antibiotic residues in foodstuffs

Bacanlı

2024

Arch Toxicol

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Antibiotics, which have been used for many years to treat infections, also play an important role in food contamination with antibiotic residues. There is also unnecessary use of antibiotics, particularly to increase production efficiency. Non-compliance with withdrawal periods and maximum residue limits (MRLs) for antibiotics used in food-producing animals results in undesirable events, such as allergic reactions, teratogenicity, carcinogenicity, changes in the microbiota and, in particular, antibiotic resistance. Therefore, it may be useful to avoid unnecessary use of antibiotics, to limit the use of antibiotics and to turn to alternatives that can be used instead of antibiotics. The aim of this review is to provide information on the undesirable effects of antibiotic residues in food-producing organisms and in the environment, their determination, and the precautions that can be taken.

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Exposure assessment of pesticide residues, heavy metals, and veterinary drugs through consumption of Egyptian fish samples

Ghuniem,

Gad,

Tahon

et al. 2024

Toxicology Reports

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Antibiotic Residues in Food Chains; Impact on the Environment and Human Health: A Review

Cited by 7 publications

References 0 publications

A comprehensive review on the fate and impact of antibiotic residues in the environment and public health: A special focus on the developing countries

A comprehensive review on the fate and impact of antibiotic residues in the environment and public health: A special focus on the developing countries

The two faces of antibiotics: an overview of the effects of antibiotic residues in foodstuffs

Exposure assessment of pesticide residues, heavy metals, and veterinary drugs through consumption of Egyptian fish samples

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